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Information of the project and the call

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Search for structure-antimicrobial activity correlation for selected boraheterocycles

2018/31/B/ST5/00210

Keywords:

antimicrobial activity enzyme inhibitors heterocycles

Descriptors:

  • ST5_23:
  • ST5_16:
  • NZ7_14:

Panel:

ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution :

Politechnika Warszawska, Wydział Chemiczny

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Sergiusz Mariusz Luliński 

Number of co-investigators in the project: 11

Call: OPUS 16 - announced on 2018-09-14

Amount awarded: 1 726 200 PLN

Project start date (Y-m-d): 2019-07-24

Project end date (Y-m-d): 2024-07-23

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Project description

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Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (12)
  • Articles in post-conference publications (2)
  1. Ethynyl-substituted benzosiloxaboroles: the role of C(pi)/B interactions in their crystal packing and use in Cu(I)-catalyzed 1,3-dipolar cycloaddition
    Authors:
    Piotr Pacholak, Krzysztof Durka, Krzysztof Woźniak, Joanna Krajewska, Agnieszka E. Laudy, Sergiusz Luliński
    Academic press:
    RSC Advances (rok: 2024, tom: 14, strony: 16069-16082), Wydawca: RSC
    Status:
    Published
    DOI:
    10.1039/d4ra02137a - link to the publication
  2. Exploring the effect of substitution patterns on the symmetry of hydrogen-bonded supramolecular motifs in functionalized benzosiloxaboroles
    Authors:
    Krzysztof Durka, Adam Zuba, Paulina H. Marek-Urban, Krzysztof Nowicki, Jakub Drapała, Krzysztof Woźniak, Sergiusz Luliński
    Academic press:
    CrystEngComm (rok: 2023, tom: 25, strony: 6329-6342), Wydawca: RSC
    Status:
    Published
    DOI:
    10.1039/d3ce00880k - link to the publication
  3. Mutant Prevention Concentration, Frequency of Spontaneous Mutant Selection, and Mutant Selection Window—a New Approach to the In Vitro Determination of the Antimicrobial Potency of Compounds
    Authors:
    Joanna Krajewska, Stefan Tyski, Agnieszka E. Laudy
    Academic press:
    Antimicrobial Agents and Chemotherapy (rok: 2023, tom: 67, strony: 46036), Wydawca: American Society for Microbiology
    Status:
    Published
    DOI:
    10.1128/aac.01373-22 - link to the publication
  4. Formation and Structural Characterization of Benzoxa- and Thienoxaphosphaborinines
    Authors:
    Krzysztof Nowicki, Maja Grądecka, Patrycja Kurasz, Paweł A. Wieczorkiewicz, Damian Dąbrowski, Krzysztof Durka, Sergiusz Luliński
    Academic press:
    Thr Journal of Organic Chemistry (rok: 2025, tom: 90, strony: 7688-7699), Wydawca: ACS
    Status:
    Published
    DOI:
    10.1021/acs.joc.5c00501 - link to the publication
  5. Exploiting thiol-functionalized benzosiloxaboroles for achieving diverse substitution patterns – synthesis, characterization and biological evaluation of promising antibacterial agents
    Authors:
    Krzysztof Nowicki, Joanna Krajewska, Tomasz M. Stępniewski, Monika Wielechowska, Patrycja Wińska, Anna Kaczmarczyk, Julia Korpowska, Jana Selent, Paulina H. Marek-Urban, Krzysztof Durka, Krzysztof Woźniak, Agnieszka E. Laudy, Sergiusz Luliński
    Academic press:
    RSC Medicinal Chemistry (rok: 2024, tom: 15, strony: 1751-1772), Wydawca: RSC
    Status:
    Published
    DOI:
    10.1039/d4md00061g - link to the publication
  6. In Vitro Resistance-Predicting Studies and In Vitro Resistance-Related Parameters - A Hit-to-Lead Perspective
    Authors:
    Joanna Krajewska, Stefan Tyski, Agnieszka E. Laudy
    Academic press:
    Pharmaceuticals (rok: 2024, tom: 17, strony: 1068), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ph17081068 - link to the publication
  7. Heteroelement Analogues of Benzoxaborole and Related Ring Expanded Systems
    Authors:
    Krzysztof Nowicki, Piotr Pacholak, Sergiusz Luliński
    Academic press:
    Molecules (rok: 2021, tom: 26, strony: 5464), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules26185464 - link to the publication
  8. Oxazoline scaffold in synthesis of benzosiloxaboroles and related ring-expanded heterocycles: diverse reactivity, structural peculiarities and antimicrobial activity
    Authors:
    Joanna Krajewska, Krzysztof Nowicki, Krzysztof Durka, Paulina H. Marek-Urban, Patrycja Wińska, Tomasz Stępniewski, Krzysztof Woźniak, Agnieszka E. Laudy, Sergiusz Luliński
    Academic press:
    RSC Advances (rok: 2022, tom: 12, strony: 23099–23117), Wydawca: RSC
    Status:
    Published
    DOI:
    10.1039/d2ra03910a - link to the publication
  9. Differential Sensing of Saccharides Based on an Array of Fluorinated Benzosiloxaborole Receptors
    Authors:
    Paweł Ćwik, Patrycja Ciosek-Skibińska, Marcin Zabadaj, Sergiusz Luliński, Krzysztof Durka, Wojciech Wróblewski
    Academic press:
    Sensors (rok: 2020, tom: 20, strony: 3540), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/s20123540 - link to the publication
  10. Aromatic Diboronic Acids as Effective KPC/AmpC Inhibitors
    Authors:
    Joanna Krajewska, Piotr Chyży, Krzysztof Durka, Patrycja Wińska, Krystiana A. Krzyśko, Sergiusz Luliński, Agnieszka E. Laudy
    Academic press:
    Molecules (rok: 2023, tom: 28, strony: 7362), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules28217362 - link to the publication
  11. Expedient Synthesis of Oxaboracyclic Compounds Based on Naphthalene and Biphenyl Backbone and Phase- Dependent Luminescence of their Chelate Complexes
    Authors:
    Krzysztof Durka, Paulina H. Marek-Urban, Krzysztof Nowicki, Jakub Drapała, Katarzyna N. Jarzembska, Piotr Łaski, Aleksandra Grzelak, Marek Dąbrowski, Krzysztof Woźniak, Sergiusz Luliński
    Academic press:
    Chemistry—A European Journal (rok: 2022, tom: 28, strony: e202104492), Wydawca: Wiley-VCH
    Status:
    Published
    DOI:
    10.1002/chem.202104492 - link to the publication
  12. Development of structurally extended benzosiloxaboroles – synthesis and in vitro biological evaluation
    Authors:
    P.iotr Pacholak, Joanna Krajewska, Patrycja Wińska, Jolanta Dunikowska, Urszula Gogowska, Jolanta Mierzejewska, Krzysztof Durka, Krzysztof Woźniak, Agmieszka E. Laudy, Sergiusz Luliński
    Academic press:
    RSC Advances (rok: 2021, tom: 11, strony: 25104–25121), Wydawca: RSC
    Status:
    Published
    DOI:
    10.1039/d1ra04127d - link to the publication
  1. WIELOETAPOWA METODA OTRZYMYWANIA INOKULUM BAKTERII O GĘSTOŚCI ≥10^11 CFU/ML
    Authors:
    Joanna Krajewska, Agnieszka E. Laudy
    Conference:
    XXIX ogólnopolski Zjazd Polskiego Towarzystwa Mikrobiologów (rok: 2022, ), Wydawca: Polskie Towarzystwo Mikrobiologów
    Data:
    konferencja 15-17.09.2022
    Status:
    Published
  2. Nowe parametry wyznaczania zakresu stężeń, w którym może dochodzić do selekcji lekoopornych mutantów, tzw. mutant selection window (MSW) – istotny etap badań przedklinicznych
    Authors:
    Joanna Krajewska, Sergiusz Luliński, Agnieszka Laudy
    Conference:
    XXIX ogólnopolski Zjazd Polskiego Towarzystwa Mikrobiologów (rok: 2022, ), Wydawca: Polskie Towarzystwo Mikrobiologów
    Data:
    konferencja 15-17.09.2022
    Status:
    Published

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