Projects funded by the NCN

Customized DNA-based nanocarriers to boost heart healing

Call: M-ERA.NET 2022 , Panel: NZ7

Principal investigator: dr Monika Bzowska

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

Targeted drug delivery systems - synthesis and functionalization of nanocarriers

Call: SONATA 2 , Panel: ST5

Principal investigator: dr Krzysztof Szczepanowicz

Instytut Katalizy i Fizykochemii Powierzchni im. Jerzego Habera PAN

Gaining control on XBP1s signaling as a starting point for novel cancer therapies

Call: OPUS 24 , Panel: NZ7

Principal investigator: prof. Rafał Artur Bartoszewski

Uniwersytet Wrocławski, Wydział Biotechnologii

A double whammy for the NF-κB signalling pathway: development of TAK1 and IKKβ degraders against inflammation-driven dis...

Call: OPUS 24 (LAP) , Panel: NZ7

Principal investigator: dr hab. Anna Karolina Więckowska

Uniwersytet Jagielloński, Collegium Medicum

Brain-targeted β‐hydroxy-β‐methylbutyrate administration in the prevention of insulin resistance development in the hypo...

Call: SONATA 18 , Panel: NZ7

Principal investigator: dr Elżbieta Supruniuk

Uniwersytet Medyczny w Białymstoku

Computational deciphering of pro-ferroptotic cell death protein machinery as a fundamental step in the search for therap...

Call: SONATA BIS 12 , Panel: ST4

Principal investigator: dr hab. Karolina Anna Mikulska-Rumińska

Uniwersytet Mikołaja Kopernika, Wydział Fizyki, Astronomii i Informatyki Stosowanej

A smart stride for cancer: synergistic effect of co-delivery chemo- andphototherapeutic agents using magneto-fluorescent...

Call: POLONEZ BIS 2 , Panel: NZ7

Principal investigator: dr Prachi Uttam Ghoderao

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu

Studies on the post-receptor mechanisms of TSPO in search of a novel therapeutic target of metabolic syndrome

Call: PRELUDIUM 21 , Panel: NZ7

Principal investigator: dr Łukasz Kurach

Uniwersytet Medyczny w Lublinie

Brain cytochrome P450 as a new target for the treatment of neurological and psychiatric diseases. Studies with human neu...

Call: OPUS 23 , Panel: NZ7

Principal investigator: prof. Władysława Anna Daniel

Instytut Farmakologii PAN

The role of simultaneous and individual modulation of μ-opioid, sigma-1 and histamine H3 receptors as a new therapeutic ...

Call: OPUS 23 , Panel: NZ7

Principal investigator: dr Katarzyna Anna Szczepańska

Instytut Farmakologii PAN

Impact of the CDK4/6 targeted degradation by PROTACs on immune checkpoint signaling in cancer

Call: OPUS 22 , Panel: NZ7

Principal investigator: dr Katarzyna Magiera-Mularz

Uniwersytet Jagielloński, Wydział Chemii

Novel broad-spectrum central nervous system active substances: optimization of their multi-target profile

Call: OPUS 22 , Panel: NZ7

Principal investigator: dr hab. Agnieszka Anna Kaczor

Uniwersytet Medyczny w Lublinie, Wydział Farmaceutyczny

New strategies in the treatment of non-small cell lung cancer based on silk nanocarriers targeting tumor vascularization

Call: SONATA 17 , Panel: NZ7

Principal investigator: dr Anna Katarzyna Florczak-Substyk

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu

Light-producing, oxygen-delivering, cancer cell-targeted carriers for photosensitisers dedicated for photodynamic therap...

Call: OPUS 22 , Panel: NZ7

Principal investigator: prof. Marek Arkadiusz Murias

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu

Studies on anti-inflammatory properties of GPR18 ligands and their involvement in modulation of microglia phenotypes – a...

Call: OPUS 22 , Panel: NZ7

Principal investigator: prof. Katarzyna Justyna Kieć-Kononowicz

Uniwersytet Jagielloński, Collegium Medicum

Research of multifunctional compounds targeting neuroinflammation and cholinergic deficit in Alzheimer's disease

Call: OPUS 22 (LAP) , Panel: NZ7

Principal investigator: prof. Kinga Aleksandra Sałat

Uniwersytet Jagielloński, Collegium Medicum

Specific Targeting of Antimicrobial Resistant Strains in situ using Targeted-Antibacterial-Plasmids

Call: JPIAMR-ACTION Call 2021 , Panel: NZ7

Principal investigator: dr Anna Marzec-Grządziel

Instytut Uprawy Nawożenia i Gleboznawstwa - Państwowy Instytut Badawczy

Synthetic epidermal growth factor receptor inhibitor conjugated with nobel metal nanoparticles as a potential drug for t...

Call: PRELUDIUM 20 , Panel: NZ7

Principal investigator: Shaoshan Mai

Gdański Uniwersytet Medyczny, Wydział Farmaceutyczny

In search for molecular targets to overcome doxorubicin resistance in triple-negative breast cancer with the use of inno...

Call: PRELUDIUM 20 , Panel: NZ7

Principal investigator: Anna Karolina Pogorzelska

Narodowy Instytut Leków

Aging-associated, specific pathomechanisms of endothelial dysfunction in sepsis: pathway analysis and experimental thera...

Call: WEAVE-UNISONO , Panel: NZ7

Principal investigator: prof. Stefan Karol Chłopicki

Uniwersytet Jagielloński, Jagiellońskie Centrum Rozwoju Leków (JCET)

Enzymes of the L-methionine biosynthetic pathway as novel moleculartargets for antifungal chemotherapy

Call: OPUS 20 , Panel: NZ7

Principal investigator: dr hab. Iwona Aniela Gabriel

Politechnika Gdańska, Wydział Chemiczny

The study on the molecular mechanisms of cytotoxic activity of new compounds ZOT5-1-Me and ZOT5-1-Et in an experimental ...

Call: SONATA 16 , Panel: NZ7

Principal investigator: dr Paulina Anna Tokarz

Uniwersytet Łódzki, Wydział Biologii i Ochrony Środowiska

Drug repurposing to target p53 protein family for improved therapy in the relapsed TP53 and EGFR mutated lung cancer

Call: OPUS 20 , Panel: NZ7

Principal investigator: dr Joanna Elżbieta Zawacka-Pankau

Warszawski Uniwersytet Medyczny

Exploring new drug targets for efficacious therapy of neuropathic pain basing on the assessment and modulation of neuroi...

Call: OPUS 2 , Panel: NZ4

Principal investigator: dr hab. Joanna Gabriela Mika

Instytut Farmakologii PAN

DNA polymerase θ as a novel therapeutic target in personalized anticancer therapy

Call: OPUS 19 , Panel: NZ7

Principal investigator: prof. Tomasz Adam Śliwiński

Uniwersytet Łódzki, Wydział Biologii i Ochrony Środowiska

Homo- and heterometallic phosphine ruthenium and iridium complexes - design, synthesis, bioactivity and magnetic-nanofor...

Call: PRELUDIUM 19 , Panel: ST4

Principal investigator: Sandra Amanda Kozieł

Uniwersytet Wrocławski, Wydział Chemii

New multifunctional drug-like ligands focusing on molecular targets associated with the symptoms and causes of Alzheimer...

Call: PRELUDIUM 19 , Panel: NZ7

Principal investigator: Anna Marta Pasieka

Uniwersytet Jagielloński, Collegium Medicum

Novel L-asparaginases as potential therapeutic agents and antimicrobial targets: structural and functional studies of en...

Call: OPUS 19 , Panel: NZ1

Principal investigator: prof. Mariusz Jaskólski

Instytut Chemii Bioorganicznej PAN

Novel approach in the search for asthma and COPD therapies - computer aided design of multi-target-directed ligands bloc...

Call: PRELUDIUM 19 , Panel: NZ7

Principal investigator: Alicja Aleksandra Gawalska

Uniwersytet Jagielloński, Collegium Medicum

Physical exercise as a natural mechanism inducing neuroregeneration. Search for the new protein markers and therapeutic ...

Call: OPUS 18 , Panel: NZ7

Principal investigator: dr hab. Katarzyna Zofia Kuter-Nowak

Instytut Farmakologii PAN

Synthetic analogues of opioid growth factor linked to derivatives of glucosamine as a potential compounds for targeted t...

Call: OPUS 18 , Panel: NZ7

Principal investigator: prof. Iwona Maria Inkielewicz-Stępniak

Gdański Uniwersytet Medyczny, Wydział Farmaceutyczny

Gankyrin protein as a new potential therapeutic target in multiple myeloma

Call: OPUS 18 , Panel: NZ5

Principal investigator: dr hab. Irena Misiewicz-Krzemińska

Instytut Hematologii i Transfuzjologii

Lactoferrin and versatile polymers as a tool for selective and targeted delivery of anticancer hydrophobic drugs in the ...

Call: PRELUDIUM 18 , Panel: NZ7

Principal investigator: Przemysław Krzysztof Gajda-Morszewski

Uniwersytet Jagielloński, Wydział Chemii

Dual-targeted biodegradable polymeric micelles for anticancer drug delivery

Call: SONATA BIS 9 , Panel: NZ7

Principal investigator: dr Katarzyna Jelonek

Centrum Materiałów Polimerowych i Węglowych PAN

The use of olaparib and ATR / CHK1 kinase inhibitors as a targeted anti-cancer therapy based on synthetic lethality

Call: SONATA BIS 9 , Panel: NZ7

Principal investigator: dr hab. Aneta Katarzyna Rogalska

Uniwersytet Łódzki, Wydział Biologii i Ochrony Środowiska

Novel core-shell micro-sized systems for macrophage-targeted drug delivery via phagocytosis

Call: PRELUDIUM 17 , Panel: NZ7

Principal investigator: dr Tomasz Marek Urbaniak

Uniwersytet Medyczny im. Piastów Śląskich we Wrocławiu, Wydział Farmaceutyczny z Oddziałem Analiutyki Medycznej

Biased multi-target ligands as tools for activity pattern analysis of G protein-coupled receptors in cancer cells

Call: SONATA 14 , Panel: NZ7

Principal investigator: dr Artur Wnorowski

Uniwersytet Medyczny w Lublinie, Wydział Farmaceutyczny z Oddziałem Analityki Medycznej

Atomization of liquids for targeted drug delivery to the respiratory system - mechanisms of droplets formation, transpor...

Call: OPUS 15 , Panel: ST8

Principal investigator: prof. Tomasz Robert Sosnowski

Politechnika Warszawska, Wydział Inżynierii Chemicznej i Procesowej

Application of targeted metabolomic approach in quantitative prospective analysis of nucleosides profiles alterations be...

Call: PRELUDIUM 15 , Panel: NZ7

Principal investigator: Małgorzata Artymowicz

Gdański Uniwersytet Medyczny

Opioid-induced analgesia and hyperalgesia in neuropathic pain - mechanisms and druggable targets

Call: OPUS 15 , Panel: NZ7

Principal investigator: prof. Barbara Elżbieta Przewłocka

Instytut Farmakologii PAN

Novel multi-target ligands of aminergic GPCRs as pharmacological tools to study the pathomechanism of schzophrenia

Call: OPUS 14 , Panel: NZ7

Principal investigator: dr hab. Agnieszka Anna Kaczor

Uniwersytet Medyczny w Lublinie, Wydział Farmaceutyczny

Nanostructured lipidic liquid-crystalline carriers for chemotherapeutics and corpuscular radiation emitters in targeted ...

Call: OPUS 13 , Panel: ST4

Principal investigator: dr Ewa Nazaruk

Uniwersytet Warszawski, Wydział Chemii

The enzymes of RNA metabolism, PAP I and PNPase, as targets for new antimycobacterial drugs and their functional charact...

Call: OPUS 13 , Panel: NZ7

Principal investigator: prof. Jarosław Dziadek

Instytut Biologii Medycznej PAN

Determination of arginase-1 as a potential drug target in the treatment of multiple myeloma and in reducing proteasome i...

Call: OPUS 13 , Panel: NZ6

Principal investigator: prof. Jakub Adam Gołąb

Warszawski Uniwersytet Medyczny, Wydział Lekarski

Peroxiredoxins as potential therapeutic targets in glioblastoma.

Call: OPUS 13 , Panel: NZ7

Principal investigator: dr hab. Monika Paulina Szeliga

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

Exosome biosensors - new tools in cancer screening, diagnostics and development of targeted drug delivery system

Call: OPUS 13 , Panel: ST4

Principal investigator: dr hab. Magdalena Stobiecka

Szkoła Główna Gospodarstwa Wiejskiego w Warszawie, Instytut Biologii

Novel 2,4-disubstituted pyridine derivatives - synthesis, antimycobacterial activity in vitro, pharmacophore model, mole...

Call: OPUS 13 , Panel: NZ7

Principal investigator: dr hab. Katarzyna Małgorzata Gobis

Gdański Uniwersytet Medyczny, Wydział Farmaceutyczny

Model of lipid nanoagregates transport by epitelial cells with additional steps of pharmacokinetic

Call: PRELUDIUM 13 , Panel: NZ7

Principal investigator: Kamila Szostak-Paluch

Politechnika Wrocławska

Chemical effects in targeted drug delivery: The roles of anticancer drugs, carriers and conjugates on biomimetic membran...

Call: SONATA 12 , Panel: ST4

Principal investigator: dr Dorota Maria Nieciecka

Uniwersytet Warszawski, Wydział Chemii

In vitro studies of NaA nanozeolite functionalized with integrins inhibitor- cilengitide and labeled with radium radioiz...

Call: SONATA 12 , Panel: NZ7

Principal investigator: dr Sylwia Męczyńska-Wielgosz

Instytut Chemii i Techniki Jądrowej