Projects funded by the NCN

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120 projects found matching your search criteria :

  1. A double whammy for the NF-κB signalling pathway: development of TAK1 and IKKβ degraders against inflammation-driven dis...

    Call: OPUS 24 (LAP) , Panel: NZ7

    Principal investigator: dr hab. Anna Karolina Więckowska

    Uniwersytet Jagielloński, Collegium Medicum

  2. Brain-targeted β‐hydroxy-β‐methylbutyrate administration in the prevention of insulin resistance development in the hypo...

    Call: SONATA 18 , Panel: NZ7

    Principal investigator: dr Elżbieta Supruniuk

    Uniwersytet Medyczny w Białymstoku

  3. Computational deciphering of pro-ferroptotic cell death protein machinery as a fundamental step in the search for therap...

    Call: SONATA BIS 12 , Panel: ST4

    Principal investigator: dr hab. Karolina Anna Mikulska-Rumińska

    Uniwersytet Mikołaja Kopernika w Toruniu, Wydział Fizyki, Astronomii i Informatyki Stosowanej

  4. A smart stride for cancer: synergistic effect of co-delivery chemo- andphototherapeutic agents using magneto-fluorescent...

    Call: POLONEZ BIS 2 , Panel: NZ7

    Principal investigator: dr Prachi Uttam Ghoderao

    Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu

  5. Studies on the post-receptor mechanisms of TSPO in search of a novel therapeutic target of metabolic syndrome

    Call: PRELUDIUM 21 , Panel: NZ7

    Principal investigator: dr Łukasz Kurach

    Uniwersytet Medyczny w Lublinie

  6. Brain cytochrome P450 as a new target for the treatment of neurological and psychiatric diseases. Studies with human neu...

    Call: OPUS 23 , Panel: NZ7

    Principal investigator: prof. Władysława Anna Daniel

    Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

  7. The role of simultaneous and individual modulation of μ-opioid, sigma-1 and histamine H3 receptors as a new therapeutic ...

    Call: OPUS 23 , Panel: NZ7

    Principal investigator: dr Katarzyna Anna Szczepańska

    Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

  8. Impact of the CDK4/6 targeted degradation by PROTACs on immune checkpoint signaling in cancer

    Call: OPUS 22 , Panel: NZ7

    Principal investigator: dr Katarzyna Magiera-Mularz

    Uniwersytet Jagielloński, Wydział Chemii

  9. Novel broad-spectrum central nervous system active substances: optimization of their multi-target profile

    Call: OPUS 22 , Panel: NZ7

    Principal investigator: dr hab. Agnieszka Anna Kaczor

    Uniwersytet Medyczny w Lublinie, Wydział Farmaceutyczny

  10. New strategies in the treatment of non-small cell lung cancer based on silk nanocarriers targeting tumor vascularization

    Call: SONATA 17 , Panel: NZ7

    Principal investigator: dr Anna Katarzyna Florczak-Substyk

    Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu

  11. Light-producing, oxygen-delivering, cancer cell-targeted carriers for photosensitisers dedicated for photodynamic therap...

    Call: OPUS 22 , Panel: NZ7

    Principal investigator: prof. Marek Arkadiusz Murias

    Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu

  12. Studies on anti-inflammatory properties of GPR18 ligands and their involvement in modulation of microglia phenotypes – a...

    Call: OPUS 22 , Panel: NZ7

    Principal investigator: prof. Katarzyna Justyna Kieć-Kononowicz

    Uniwersytet Jagielloński, Collegium Medicum

  13. Research of multifunctional compounds targeting neuroinflammation and cholinergic deficit in Alzheimer's disease

    Call: OPUS 22 (LAP) , Panel: NZ7

    Principal investigator: prof. Kinga Aleksandra Sałat

    Uniwersytet Jagielloński, Collegium Medicum

  14. Specific Targeting of Antimicrobial Resistant Strains in situ using Targeted-Antibacterial-Plasmids

    Call: CHIST-ERA2020 , Panel: NZ7

    Principal investigator: dr Anna Marzec-Grządziel

    Instytut Uprawy Nawożenia i Gleboznawstwa - Państwowy Instytut Badawczy

  15. Synthetic epidermal growth factor receptor inhibitor conjugated with nobel metal nanoparticles as a potential drug for t...

    Call: PRELUDIUM 20 , Panel: NZ7

    Principal investigator: Shaoshan Mai

    Gdański Uniwersytet Medyczny, Wydział Farmaceutyczny

  16. In search for molecular targets to overcome doxorubicin resistance in triple-negative breast cancer with the use of inno...

    Call: PRELUDIUM 20 , Panel: NZ7

    Principal investigator: Anna Karolina Pogorzelska

    Narodowy Instytut Leków

  17. Aging-associated, specific pathomechanisms of endothelial dysfunction in sepsis: pathway analysis and experimental thera...

    Call: CHIST-ERA2020 , Panel: NZ7

    Principal investigator: prof. Stefan Karol Chłopicki

    Uniwersytet Jagielloński

  18. Enzymes of the L-methionine biosynthetic pathway as novel moleculartargets for antifungal chemotherapy

    Call: OPUS 20 , Panel: NZ7

    Principal investigator: dr hab. Iwona Aniela Gabriel

    Politechnika Gdańska, Wydział Chemiczny

  19. The study on the molecular mechanisms of cytotoxic activity of new compounds ZOT5-1-Me and ZOT5-1-Et in an experimental ...

    Call: SONATA 16 , Panel: NZ7

    Principal investigator: dr Paulina Anna Tokarz

    Uniwersytet Łódzki, Wydział Biologii i Ochrony Środowiska

  20. Drug repurposing to target p53 protein family for improved therapy in the relapsed TP53 and EGFR mutated lung cancer

    Call: OPUS 20 , Panel: NZ7

    Principal investigator: dr Joanna Elżbieta Zawacka-Pankau

    Warszawski Uniwersytet Medyczny

  21. Exploring new drug targets for efficacious therapy of neuropathic pain basing on the assessment and modulation of neuroi...

    Call: OPUS 2 , Panel: NZ4

    Principal investigator: dr hab. Joanna Gabriela Mika

    Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

  22. DNA polymerase θ as a novel therapeutic target in personalized anticancer therapy

    Call: OPUS 19 , Panel: NZ7

    Principal investigator: prof. Tomasz Adam Śliwiński

    Uniwersytet Łódzki, Wydział Biologii i Ochrony Środowiska

  23. Homo- and heterometallic phosphine ruthenium and iridium complexes - design, synthesis, bioactivity and magnetic-nanofor...

    Call: PRELUDIUM 19 , Panel: ST4

    Principal investigator: Sandra Amanda Kozieł

    Uniwersytet Wrocławski, Wydział Chemii

  24. New multifunctional drug-like ligands focusing on molecular targets associated with the symptoms and causes of Alzheimer...

    Call: PRELUDIUM 19 , Panel: NZ7

    Principal investigator: Anna Marta Pasieka

    Uniwersytet Jagielloński, Collegium Medicum

  25. Novel L-asparaginases as potential therapeutic agents and antimicrobial targets: structural and functional studies of en...

    Call: OPUS 19 , Panel: NZ1

    Principal investigator: prof. Mariusz Jaskólski

    Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

  26. Novel approach in the search for asthma and COPD therapies - computer aided design of multi-target-directed ligands bloc...

    Call: PRELUDIUM 19 , Panel: NZ7

    Principal investigator: Alicja Aleksandra Gawalska

    Uniwersytet Jagielloński, Collegium Medicum

  27. Physical exercise as a natural mechanism inducing neuroregeneration. Search for the new protein markers and therapeutic ...

    Call: OPUS 18 , Panel: NZ7

    Principal investigator: dr hab. Katarzyna Zofia Kuter-Nowak

    Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

  28. Synthetic analogues of opioid growth factor linked to derivatives of glucosamine as a potential compounds for targeted t...

    Call: OPUS 18 , Panel: NZ7

    Principal investigator: prof. Iwona Maria Inkielewicz-Stępniak

    Gdański Uniwersytet Medyczny, Wydział Farmaceutyczny

  29. Gankyrin protein as a new potential therapeutic target in multiple myeloma

    Call: OPUS 18 , Panel: NZ5

    Principal investigator: dr hab. Irena Misiewicz-Krzemińska

    Instytut Hematologii i Transfuzjologii

  30. Lactoferrin and versatile polymers as a tool for selective and targeted delivery of anticancer hydrophobic drugs in the ...

    Call: PRELUDIUM 18 , Panel: NZ7

    Principal investigator: Przemysław Krzysztof Gajda-Morszewski

    Uniwersytet Jagielloński, Wydział Chemii

  31. Dual-targeted biodegradable polymeric micelles for anticancer drug delivery

    Call: SONATA BIS 9 , Panel: NZ7

    Principal investigator: dr Katarzyna Jelonek

    Centrum Materiałów Polimerowych i Węglowych Polskiej Akademii Nauk

  32. The use of olaparib and ATR / CHK1 kinase inhibitors as a targeted anti-cancer therapy based on synthetic lethality

    Call: SONATA BIS 9 , Panel: NZ7

    Principal investigator: dr hab. Aneta Katarzyna Rogalska

    Uniwersytet Łódzki, Wydział Biologii i Ochrony Środowiska

  33. Novel core-shell micro-sized systems for macrophage-targeted drug delivery via phagocytosis

    Call: PRELUDIUM 17 , Panel: NZ7

    Principal investigator: dr Tomasz Marek Urbaniak

    Uniwersytet Medyczny im. Piastów Śląskich we Wrocławiu

  34. Biased multi-target ligands as tools for activity pattern analysis of G protein-coupled receptors in cancer cells

    Call: SONATA 14 , Panel: NZ7

    Principal investigator: dr Artur Wnorowski

    Uniwersytet Medyczny w Lublinie, Wydział Farmaceutyczny z Oddziałem Analityki Medycznej

  35. Atomization of liquids for targeted drug delivery to the respiratory system - mechanisms of droplets formation, transpor...

    Call: OPUS 15 , Panel: ST8

    Principal investigator: prof. Tomasz Robert Sosnowski

    Politechnika Warszawska, Wydział Inżynierii Chemicznej i Procesowej

  36. Application of targeted metabolomic approach in quantitative prospective analysis of nucleosides profiles alterations be...

    Call: PRELUDIUM 15 , Panel: NZ7

    Principal investigator: Małgorzata Artymowicz

    Gdański Uniwersytet Medyczny

  37. Opioid-induced analgesia and hyperalgesia in neuropathic pain - mechanisms and druggable targets

    Call: OPUS 15 , Panel: NZ7

    Principal investigator: prof. Barbara Elżbieta Przewłocka

    Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

  38. Novel multi-target ligands of aminergic GPCRs as pharmacological tools to study the pathomechanism of schzophrenia

    Call: OPUS 14 , Panel: NZ7

    Principal investigator: dr hab. Agnieszka Anna Kaczor

    Uniwersytet Medyczny w Lublinie, Wydział Farmaceutyczny

  39. Nanostructured lipidic liquid-crystalline carriers for chemotherapeutics and corpuscular radiation emitters in targeted ...

    Call: OPUS 13 , Panel: ST4

    Principal investigator: dr Ewa Nazaruk

    Uniwersytet Warszawski, Wydział Chemii

  40. The enzymes of RNA metabolism, PAP I and PNPase, as targets for new antimycobacterial drugs and their functional charact...

    Call: OPUS 13 , Panel: NZ7

    Principal investigator: prof. Jarosław Dziadek

    Instytut Biologii Medycznej Polskiej Akademii Nauk

  41. Determination of arginase-1 as a potential drug target in the treatment of multiple myeloma and in reducing proteasome i...

    Call: OPUS 13 , Panel: NZ6

    Principal investigator: prof. Jakub Adam Gołąb

    Warszawski Uniwersytet Medyczny, Wydział Lekarski

  42. Peroxiredoxins as potential therapeutic targets in glioblastoma.

    Call: OPUS 13 , Panel: NZ7

    Principal investigator: dr hab. Monika Paulina Szeliga

    Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego Polskiej Akademii Nauk

  43. Exosome biosensors - new tools in cancer screening, diagnostics and development of targeted drug delivery system

    Call: OPUS 13 , Panel: ST4

    Principal investigator: dr hab. Magdalena Stobiecka

    Szkoła Główna Gospodarstwa Wiejskiego w Warszawie, Instytut Biologii

  44. Novel 2,4-disubstituted pyridine derivatives - synthesis, antimycobacterial activity in vitro, pharmacophore model, mole...

    Call: OPUS 13 , Panel: NZ7

    Principal investigator: dr hab. Katarzyna Małgorzata Gobis

    Gdański Uniwersytet Medyczny, Wydział Farmaceutyczny

  45. Model of lipid nanoagregates transport by epitelial cells with additional steps of pharmacokinetic

    Call: PRELUDIUM 13 , Panel: NZ7

    Principal investigator: Kamila Szostak-Paluch

    Politechnika Wrocławska

  46. Chemical effects in targeted drug delivery: The roles of anticancer drugs, carriers and conjugates on biomimetic membran...

    Call: SONATA 12 , Panel: ST4

    Principal investigator: dr Dorota Maria Nieciecka

    Uniwersytet Warszawski, Wydział Chemii

  47. In vitro studies of NaA nanozeolite functionalized with integrins inhibitor- cilengitide and labeled with radium radioiz...

    Call: SONATA 12 , Panel: NZ7

    Principal investigator: dr Sylwia Męczyńska-Wielgosz

    Instytut Chemii i Techniki Jądrowej

  48. Insights into biological activity and mechanism of action of novel styrylquinazoline derivatives as tyrosine kinase inhi...

    Call: PRELUDIUM 12 , Panel: NZ7

    Principal investigator: Katarzyna Anna Malarz

    Uniwersytet Śląski w Katowicach, Wydział Matematyki, Fizyki i Chemii

  49. Inhibitors of anti-apoptotic proteins from the BCL-2 family as agents enhancing BRAFV600E inhibition in melanoma cells.

    Call: SONATA 12 , Panel: NZ7

    Principal investigator: dr Mariusz Hartman

    Uniwersytet Medyczny w Łodzi, Międzywydziałowa Katedra Chemii i Biochemii Medycznej

  50. Identification and targeting molecular drug resistance mechanisms in adult B-cell acute lymphoblastic leukemia

    Call: OPUS 1 , Panel: NZ4

    Principal investigator: dr hab. Przemysław Juszczyński

    Instytut Hematologii i Transfuzjologii

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