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Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Preparation and physico-chemical evaluation of mesoporous oxide matrices as carriers in a model of the implant to the bone with targeted-controlled release of doxorubicin hydrochloride and metronidazole

2012/07/B/NZ7/04385

Keywords:

mesoporous oxide matrices carriers of drug substances targeted-controlled release

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Gdański Uniwersytet Medyczny, Wydział Farmaceutyczny z Oddziałem Medycyny Laboratoryjnej

woj. pomorskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Wiesław Sawicki 

Number of co-investigators in the project: 3

Call: OPUS 4 - announced on 2012-09-15

Amount awarded: 604 710 PLN

Project start date (Y-m-d): 2013-07-18

Project end date (Y-m-d): 2018-07-17

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Aparat do badania uwalniania substancji leczniczych metodą przepływową (USP apparatus 4) - urządzenie DFZ 720 firmy ERWEKA z wyposażeniem (pompa tłokowa HKP 720, autosampler FRL 824, moduł LMT do zbudowania systemu zamkniętego Closed Loop). (370 000 PLN)
  2. Sprzęt komputerowy - komputer z zasilaczem UPS (5 000 PLN)
  3. Piec muflowy.
  4. Aparat do fluidalnego powlekania proszków i granulatów.

Information in the final report

  • Publication in academic press/journals (4)
  • Articles in post-conference publications (6)
  1. Formulation and In Vitro Characterization of Bioactive Mesoporous Silica with Doxorubicin and Metronidazole Intended for Bone Treatment and Regeneration
    Authors:
    Katarzyna Czarnobaj, Magdalena Prokopowicz, Wiesław Sawicki
    Academic press:
    AAPS PharmSciTech (rok: 2017, tom: 18, strony: 3163-3171), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1208/s12249-017-0804-3 - link to the publication
  2. Monolithic polydimethylsiloxane-modified silica composites prepared by a low-temperature sol-gel micromolding technique for controlled drug release
    Authors:
    MAGDALENA PROKOPOWICZ, ADRIAN SZEWCZYK, Rafał Łunio, WIESŁAW SAWICKI
    Academic press:
    React. Funct. Polym. (rok: 2017, tom: 114, strony: 136-145), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.reactfunctpolym.2017.03.014 - link to the publication
  3. Bioactive monolithic composites of silica/polydimethylsiloxane/calcium phosphate obtained at room temperature in sol-gel micromolding technique
    Authors:
    MAGDALENA PROKOPOWICZ, Adrian Szewczyk, WIESŁAW SAWICKI
    Academic press:
    Mater. Lett. (rok: 2016, tom: 184, strony: 239-242), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.matlet.2016.08.063 - link to the publication
  4. Preparation and in vitro characterisation of bioactive mesoporous silica microparticles for drug delivery applications
    Authors:
    Magdalena Prokopowicz, Katarzyna Czarnobaj, Adrian Szewczyk, Wiesław Sawicki
    Academic press:
    Materials Science and Engineering: C (rok: 2016, tom: 60, strony: 45491), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.msec.2015.11.017 - link to the publication
  1. Charakterystyka strukturalna i powierzchniowa materiałów mezoporowatych typu MCM-41 jako nośników dla metronidazolu
    Authors:
    KATARZYNA CZARNOBAJ, WIESŁAW SAWICKI
    Conference:
    XXIII Naukowy Zjazd Polskiego Towarzystwa Farmaceutycznego : Farmacja w Polsce perspektywy nauki i zawodu (rok: 2017, ), Wydawca: PTFarm
    Data:
    konferencja 19-22 IX 2017
    Status:
    Published
    DOI:
    link to the publication
  2. Formulation and in vitro characterization of porous silica as drug delivery system and regenerative device for bone
    Authors:
    WIESŁAW SAWICKI, KATARZYNA CZARNOBAJ, MAGDALENA PROKOPOWICZ
    Conference:
    International Conference on Progressive PharmSciences: Technology, Research and Development (rok: 2017, ), Wydawca: United Scientific Group
    Data:
    konferencja 19-21.06
    Status:
    Published
    DOI:
    link to the publication
  3. Mesoporous silica-based materials as delivery system for doxorubicin hydrochloride and metronidazole
    Authors:
    K[ATARZYNA] CZARNOBAJ, M[AGDALENA] PROKOPOWICZ, A. Szewczyk, W[IESŁAW] SAWICKI
    Conference:
    CRS Annual Meeting and Exposition, CRS 2014, Chicago, Illinois, U.S.A. (rok: 2014, ), Wydawca: CRS
    Data:
    konferencja July 13-16, 2014
    Status:
    Published
  4. Impact of physicochemical properties and forms of mesoporous silica with doxorubicin and metronidazole on surface mineralization activity and in vitro drug release behavior
    Authors:
    Katarzyna Czarnobaj, Magdalena Prokopowicz, Wiesław Sawicki
    Conference:
    11th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology (rok: 2018, ), Wydawca: PBP
    Data:
    konferencja 19-22. 03.
    Status:
    Published
    DOI:
    link to the publication
  5. Preparation and in vitro characterisation of bioactive mesoporous silica microparticles for doxorubicin delivery applications
    Authors:
    MAGDALENA PROKOPOWICZ, KATARZYNA CZARNOBAJ, Adrian Szewczyk, WIESŁAW SAWICKI
    Conference:
    10th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Glasgow, United Kingdom, (rok: 2016, ), Wydawca: PBP
    Data:
    konferencja 4-7.04
    Status:
    Published
  6. The pelletization process of mesoporous silica materials using granulation, extrusion and spheronization method in laboratory scale
    Authors:
    Adrian Szewczyk, Magdalena Prokopowicz, Wiesław Sawicki
    Conference:
    11th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology (rok: 2018, ), Wydawca: PBP
    Data:
    konferencja 19-22. 03
    Status:
    Published
    DOI:
    link to the publication

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