Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Identification of new, clinically relevant genetic and epigenetic aberrations by next-generation sequencing in chronic myeloid leukemia patients with poor disease outcome

2014/14/M/NZ5/00441

Keywords:

chronic myeloid leukemia targeted therapy drug resistance blast crisis leukemic stem cells next-generation sequencing whole-exome and methylome sequencing synthetic lethality

Descriptors:

  • NZ2_2: Genomics, transcriptomics, epigenomics
  • NZ5_3: Pathogenesis of human diseases
  • NZ2_1: Molecular genetics

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Warszawski Uniwersytet Medyczny, Wydział Lekarski

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Tomasz Stokłosa 

Number of co-investigators in the project: 11

Call: HARMONIA 6 - announced on 2014-06-16

Amount awarded: 1 802 112 PLN

Project start date (Y-m-d): 2015-05-21

Project end date (Y-m-d): 2020-11-20

Project duration:: 66 months (the same as in the proposal)

Project status: Project settled

Information in the final report

  • Publication in academic press/journals (8)
  1. HRAS mutation positive multiple myeloma in the type 2 CALR mutation positive essential thrombocythemia: A case report
    Authors:
    Lewandowski Krzysztof , Kopydłowska Agata , Kanduła Zuzanna , Sankowski Bartłomiej , Machnicki Marcin , Barańska Marta , Gwóźdź-Bąk Kinga , Kubicki Tadeusz , Płotka Anna , Przysiecka Łucja , Dworacki Grzegorz , Kozłowski Piotr , Stokłosa Tomasz
    Academic press:
    Journal of Cellular and Molecular Medicine (rok: 2022, ), Wydawca: John Wiley & Sons Ltd
    Status:
    Published
    DOI:
    10.1111/jcmm.17647 - link to the publication
  2. Normal ABL1 is a tumor suppressor and therapeutic target in human and mouse leukemias expressing oncogenic ABL1 kinases.
    Authors:
    Dasgupta Y, Koptyra M, Hoser G, Kantekure K, Roy D, Gornicka B, Nieborowska-Skorska M, Bolton-Gillespie E, Cerny-Reiterer S, Müschen M, Valent P, Wasik MA, Richardson C, Hantschel O, van der Kuip H, Stoklosa T, Skorski T.
    Academic press:
    Blood (rok: 2016, tom: 127, strony: 2131-43), Wydawca: American Society of Hematology
    Status:
    Published
    DOI:
    10.1182/blood-2015-11-681171 - link to the publication
  3. Targeting integrated stress response with ISRIB combined with imatinib treatment attenuates RAS/RAF/MAPK and STAT5 signaling and eradicates chronic myeloid leukemia cells
    Authors:
    Wioleta Dudka, Grazyna Hoser , Shamba S Mondal , Laura Turos-Korgul, Julian Swatler, Monika Kusio-Kobialka, Magdalena Wołczyk, Agata Klejman, Marta Brewinska-Olchowik, Agata Kominek, Milena Wiech, Marcin M Machnicki , Ilona Seferynska , Tomasz Stoklosa , Katarzyna Piwocka
    Academic press:
    BMC Cancer (rok: 2022, tom: 22, strony: 1254), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1186/s12885-022-10289-w - link to the publication
  4. First familial cases of type 2 congenital erythrocytosis (ECYT2) with a Chuvash pathogenic variant in VHL gene in Poland: example of the clinical utility of next-generation sequencing in diagnostics of orphan diseases
    Authors:
    Monika Pępek, Wioletta Bal, Monika Radwańska, Marcin M. Machnicki, Małgorzata Kurkowiak, Malgorzata Rydzanicz, Agnieszka Pollak, Piotr Stawiński, Rafał Płoski, Radosław Chaber, Tomasz Stokłosa
    Academic press:
    Acta Haematologica Polonica (rok: 2020, tom: 51, strony: 220-225), Wydawca: Via Medica
    Status:
    Published
    DOI:
    10.2478/ahp-2020-0038 - link to the publication
  5. Genomic landscape of human erythroleukemia K562 cell line, as determined by next-generation sequencing and cytogenetics
    Authors:
    Kurkowiak Małgorzata, Pępek Monika, Machnicki Marcin M, Solarska Iwona, Borg Katarzyna, Rydzanicz Małgorzata, Stawiński Piotr, Płoski Rafał, Stokłosa Tomasz
    Academic press:
    Acta Haematologica Polonica (rok: 2017, tom: 48, strony: 343-349), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.achaem.2017.06.002 - link to the publication
  6. Germline missense NF1 mutation in an elderly patient with a blastic plasmacytoid dendritic cell neoplasm
    Authors:
    Andrzej Szczepaniak, Marcin Machnicki, Michał Gniot, Monika Pępek, Małgorzata Rydzanicz, Rafał Płoski, Maciej Kaźmierczak, Tomasz Stokłosa, Krzysztof Lewandowski
    Academic press:
    International Journal of Hematology (rok: 2019, tom: 110, strony: 102-106), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s12185-019-02642-w - link to the publication
  7. Co-occurrence of unclassified myeloproliferative neoplasm and giant cell arteritis in a patient treated with allogeneic hematopoietic stem cell transplantation: a case report and literature review
    Authors:
    ALEKSANDRA BOGUCKA-FEDORCZUK, ANNA CZYŻ, ANDRZEJ SZUBA, MARCIN M. MACHNICKI, MONIKA PĘPEK, RAFAŁ PŁOSKI, TOMASZ STOKŁOSA, TOMASZ WRÓBEL
    Academic press:
    Central European Journal of Immunology (rok: 2021, tom: 46, strony: 45297), Wydawca: Termedia
    Status:
    Published
    DOI:
    10.5114/ceji.2019.83140 - link to the publication
  8. Tyrosine kinase inhibitor-induced defects in DNA repair sensitize FLT3(ITD)-positive leukemia cells to PARP1 inhibitors
    Authors:
    Maifrede S, Nieborowska-Skorska M, Sullivan-Reed K, Dasgupta Y, Podszywalow-Bartnicka P, Le BV, Solecka M, Lian Z, Belyaeva EA, Nersesyan A, Machnicki MM, Toma M, Chatain N, Rydzanicz M, Zhao H, Jelinek J, Piwocka K, Sliwinski T, Stoklosa T, Ploski R, Fischer T, Sykes SM, Koschmieder S, Bullinger L, Valent P, Wasik MA, Huang J, Skorski T.
    Academic press:
    Blood (rok: 2018, tom: 132, strony: 67-77), Wydawca: American Society of Hematology
    Status:
    Published
    DOI:
    10.1182/blood-2018-02-834895 - link to the publication

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