Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Nanostructured lipidic liquid-crystalline carriers for chemotherapeutics and corpuscular radiation emitters in targeted cancer theraphy

2017/25/B/ST4/02817

Keywords:

drug delivery cubic phase cubosome tergeted radionuclide theraphy

Descriptors:

  • ST4_16: Ionic liquids
  • ST4_2: Spectroscopic and spectrometric techniques
  • ST4_18: Radiation and nuclear chemistry

Panel:

ST4 - Chemistry: physical chemistry/chemical physics, theoretical chemistry, analytical chemistry, inorganic chemistry, organic chemistry, method development

Host institution :

Uniwersytet Warszawski, Wydział Chemii

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Ewa Nazaruk 

Number of co-investigators in the project: 5

Call: OPUS 13 - announced on 2017-03-15

Amount awarded: 892 400 PLN

Project start date (Y-m-d): 2018-02-14

Project end date (Y-m-d): 2022-02-13

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Wyparka obrotowa (17 000 PLN)
  2. Cieplarka z chłodzeniem (17 000 PLN)
  3. Potencjostat (70 000 PLN)
  4. Wielodetekcyjny czytnik mikropłytek do badań cytotoksyczności in vitro (80 000 PLN)
  5. Jednostka sterująca do czytnika wielodetekcyjnego (6 133 PLN)
  6. Termoblok - urządzenie do wytrząsania i ogrzewania próbek.
  7. Wielodetetekcyjny czytnik płytek.

Information in the final report

  • Publication in academic press/journals (4)
  1. Combinatory treatment with mir-7-5p and drug-loaded cubosomes effectively impairs cancer cells
    Authors:
    Gajda E., Godlewska M., Mariak Z., Nazaruk E., Gaweł D.
    Academic press:
    International Journal of Molecular Sciences (rok: 2020, tom: 21 (14), strony: 45310), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21145039 - link to the publication
  2. Voltammetric and biological studies of folate-targeted non-lamellar lipid mesophases
    Authors:
    Godlewska, M., Majkowska-Pilip, A., Stachurska, A., (...), Gaweł, D., Nazaruk, E.
    Academic press:
    Electrochimica Acta (rok: 2019, tom: 299, strony: 45302), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.electacta.2018.12.164 - link to the publication
  3. Cubosomal Lipid Formulation for combination cancer treatment: delivery of chemotherapeutic agent and complexed α-particle emitter 213Bi
    Authors:
    Adrianna Cytryniak, Kinga Żelechowska-Matysiak, Ewa Nazaruk, Renata Bilewicz, Rafał Walczak, Emilia Majka, Adam Mames, Frank Bruchertseifer, Alfred Morgenstern, Aleksander Bilewicz, Agnieszka Majkowska-Pilip
    Academic press:
    Molecular Pharmaceutics (rok: 2022, tom: b.d, strony: b.d), Wydawca: ACS Publications
    Status:
    Published
    DOI:
    10.1021/acs.molpharmaceut.2c00182 - link to the publication
  4. Lipidic cubic-phase nanoparticles (Cubosomes) loaded with doxorubicin and labeled with177 lu as a potential tool for combined chemo and internal radiotherapy for cancers
    Authors:
    Cytryniak, A. Nazaruk E., Bilewicz R., Górzyńska E., Żelechowska-Matysiak K., Walczak R., Mames A., Bilewicz A., Majkowska-Pilip A.
    Academic press:
    Nanomaterials (rok: 2020, tom: 10 (11), strony: 45305), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/nano10112272 - link to the publication

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