Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Nanostructured lipidic liquid-crystalline carriers for chemotherapeutics and corpuscular radiation emitters in targeted cancer theraphy

2017/25/B/ST4/02817

Keywords:

drug delivery cubic phase cubosome tergeted radionuclide theraphy

Descriptors:

  • ST4_16: Ionic liquids
  • ST4_2: Spectroscopic and spectrometric techniques
  • ST4_18: Radiation and nuclear chemistry

Panel:

ST4 - Chemistry: physical chemistry/chemical physics, theoretical chemistry, analytical chemistry, inorganic chemistry, organic chemistry, method development

Host institution :

Uniwersytet Warszawski, Wydział Chemii

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Ewa Nazaruk 

Number of co-investigators in the project: 5

Call: OPUS 13 - announced on 2017-03-15

Amount awarded: 892 400 PLN

Project start date (Y-m-d): 2018-02-14

Project end date (Y-m-d): 2022-02-13

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Wielodetetekcyjny czytnik płytek.
  2. Jednostka sterująca do czytnika wielodetekcyjnego (6 133 PLN)
  3. Termoblok - urządzenie do wytrząsania i ogrzewania próbek.
  4. Wielodetekcyjny czytnik mikropłytek do badań cytotoksyczności in vitro (80 000 PLN)
  5. Wyparka obrotowa (17 000 PLN)
  6. Cieplarka z chłodzeniem (17 000 PLN)
  7. Potencjostat (70 000 PLN)

Information in the final report

  • Publication in academic press/journals (4)
  1. Combinatory treatment with mir-7-5p and drug-loaded cubosomes effectively impairs cancer cells
    Authors:
    Gajda E., Godlewska M., Mariak Z., Nazaruk E., Gaweł D.
    Academic press:
    International Journal of Molecular Sciences (rok: 2020, tom: 21 (14), strony: 45310), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21145039 - link to the publication
  2. Cubosomal Lipid Formulation for combination cancer treatment: delivery of chemotherapeutic agent and complexed α-particle emitter 213Bi
    Authors:
    Adrianna Cytryniak, Kinga Żelechowska-Matysiak, Ewa Nazaruk, Renata Bilewicz, Rafał Walczak, Emilia Majka, Adam Mames, Frank Bruchertseifer, Alfred Morgenstern, Aleksander Bilewicz, Agnieszka Majkowska-Pilip
    Academic press:
    Molecular Pharmaceutics (rok: 2022, tom: b.d, strony: b.d), Wydawca: ACS Publications
    Status:
    Published
    DOI:
    10.1021/acs.molpharmaceut.2c00182 - link to the publication
  3. Voltammetric and biological studies of folate-targeted non-lamellar lipid mesophases
    Authors:
    Godlewska, M., Majkowska-Pilip, A., Stachurska, A., (...), Gaweł, D., Nazaruk, E.
    Academic press:
    Electrochimica Acta (rok: 2019, tom: 299, strony: 45302), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.electacta.2018.12.164 - link to the publication
  4. Lipidic cubic-phase nanoparticles (Cubosomes) loaded with doxorubicin and labeled with177 lu as a potential tool for combined chemo and internal radiotherapy for cancers
    Authors:
    Cytryniak, A. Nazaruk E., Bilewicz R., Górzyńska E., Żelechowska-Matysiak K., Walczak R., Mames A., Bilewicz A., Majkowska-Pilip A.
    Academic press:
    Nanomaterials (rok: 2020, tom: 10 (11), strony: 45305), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/nano10112272 - link to the publication

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