Projects funded by the NCN

MAP kinase signaling pathway in response to replication stress and DNA damage in root meristem cells of Vicia faba

Call: PRELUDIUM 1 , Panel: NZ3

Principal investigator: Konrad Szczepan Winnicki

Uniwersytet Łódzki, Wydział Biologii i Ochrony Środowiska; Katedra Cytofizjologii

Genotoxicity of arsenic in the yeast Saccharomyces cerevisiae

Call: PRELUDIUM 1 , Panel: NZ2

Principal investigator: dr Ireneusz Bernard Litwin

Uniwersytet Wrocławski, Wydział Nauk Biologicznych

Strategy to overcome the "ionic checkpoint" and improve the antitumor immunotherapy.

Call: OPUS 29 , Panel: NZ7

Principal investigator: dr Beata Pyrzyńska

Warszawski Uniwersytet Medyczny

Dual cell cycle blockade and immune checkpoint inhibition as a potential strategy of sequential anticancer therapy

Call: PRELUDIUM 24 , Panel: NZ7

Principal investigator: Alicja Stanisława Słota

Uniwersytet Jagielloński

Novel insights into inhibition of PD-L1/PD-1 immune checkpoint – discovery and optimization of covalent PD-L1 inhibitors...

Call: SONATA 20 , Panel: ST5

Principal investigator: dr Radosław Dariusz Kitel

Uniwersytet Jagielloński

Heterogeneity immunocompetent cells during chimeric antigen receptor T cell (CAR-T) CD19 immunotherapy.

Call: PRELUDIUM 22 , Panel: NZ6

Principal investigator: Aleksandra Maria Oszer

Uniwersytet Medyczny w Łodzi, Wydział Lekarski

Multiparameter analysis of co-inhibitory and co-stimulatory immune checkpoints and their role in the induction of immuno...

Call: PRELUDIUM 22 , Panel: NZ6

Principal investigator: dr Dorota Suszczyk

Uniwersytet Medyczny w Lublinie

Development of novel anti-cancer immunotherapy against mesothelioma comprising of oncolytic adenovirus vectors armed wit...

Call: SONATA 18 , Panel: NZ7

Principal investigator: dr Łukasz Kuryk

Narodowy Instytut Zdrowia Publicznego - Państwowy Zakład Higieny (NIZP - PZH)

Role of microparticles derived from platelets and cancer cells in colorectal cancer progression – how to stop them or tu...

Call: OPUS 24 , Panel: NZ5

Principal investigator: prof. Maria Anna Kowalska

Instytut Biologii Medycznej PAN

Use of comparative oncology approach to dissect the PD-1 intrinsic signalling in osteosarcoma. Can dog be the key for ne...

Call: PRELUDIUM 21 , Panel: NZ1

Principal investigator: Katarzyna Joanna Dziubek

Uniwersytet Gdański, Międzynarodowe Centrum Badań nad Szczepionkami Przeciwnowotworowymi

Impact of the CDK4/6 targeted degradation by PROTACs on immune checkpoint signaling in cancer

Call: OPUS 22 , Panel: NZ7

Principal investigator: dr Katarzyna Magiera-Mularz

Uniwersytet Jagielloński, Wydział Chemii

New immunomodulators of BTLA-HVEM complex as potential therapeutics in systemic lupus erythematosus

Call: OPUS 22 , Panel: NZ7

Principal investigator: dr hab. Anna Wardowska

Gdański Uniwersytet Medyczny, Wydział Lekarski

The role of the immune checkpoints in the pathomechanism of depressive disorders.

Call: OPUS 22 , Panel: NZ6

Principal investigator: prof. Marta Wanda Kubera

Instytut Farmakologii PAN

Identification of Saccharomyces cerevisiae genes maintaining cell diploidy and genome stability

Call: OPUS 2 , Panel: NZ2

Principal investigator: dr hab. Adrianna Martyna Skoneczna

Instytut Biochemii i Biofizyki PAN

Photoswitchable and chimeric molecules for spatially restricted and endoplasmic reticulum-specific blockade of PD-L1 pro...

Call: SONATA BIS 11 , Panel: NZ7

Principal investigator: dr Łukasz Dariusz Skalniak

Uniwersytet Jagielloński, Wydział Chemii

Novel factors involved in cell cycle control after DNA damage.

Call: OPUS 21 , Panel: NZ1

Principal investigator: dr Michał Zbigniew Malewicz

Sieć Badawcza ŁUKASIEWICZ - PORT Polski Ośrodek Rozwoju Technologii

The SAR analysis and synthesis of complex, small molecule PD-1/PD-L1 interaction antagonists

Call: PRELUDIUM 20 , Panel: ST4

Principal investigator: Magdalena Maria Żarnik

Uniwersytet Jagielloński, Wydział Chemii

The clinical significance of immunosuppression in ovarian cancer microenvironments

Call: PRELUDIUM 20 , Panel: NZ6

Principal investigator: dr Anna Maria Pawłowska-Łachut

Uniwersytet Medyczny w Lublinie

Single cell multi-omics in defining how specific oncogenic alterations shape the immune microenvironment and responses t...

Call: OPUS 20 , Panel: NZ4

Principal investigator: prof. Bożena Kamińska-Kaczmarek

Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

Photodynamic therapy combined with PD-1/PD-L1 blockade immunotherapy: new possibilities for the treatment of immunogenic...

Call: OPUS 19 , Panel: NZ7

Principal investigator: dr hab. Janusz Marcin Dąbrowski

Uniwersytet Jagielloński, Wydział Chemii

Evaluation of the efficiency of Spindle Assembly Checkpoint during mouse oocyte meiosis

Call: OPUS 1 , Panel: NZ3

Principal investigator: dr hab. Zbigniew Piotr Polański

Uniwersytet Jagielloński, Wydział Biologii i Nauk o Ziemi

Development of a three-dimensional in vitro model for studying the mechanisms of immunostimulatory activity of PD-1/PD-L...

Call: PRELUDIUM 18 , Panel: NZ5

Principal investigator: Justyna Natalia Kocik-Król

Uniwersytet Jagielloński, Wydział Chemii

The immune checkpoints in non-small cell lung cancer - research on genetic and epigenetic mechanism regulating mRNA and ...

Call: OPUS 17 , Panel: NZ5

Principal investigator: dr hab. Monika Jasek

Instytut Immunologii i Terapii Doświadczalnej im. Ludwika Hirszfelda Polskiej Akademii Nauk

Inhibitors of BTLA-HVEM complex formation as potential targets for cancer immunotheraphy

Call: SONATA 13 , Panel: ST5

Principal investigator: dr Marta Marcelina Spodzieja

Uniwersytet Gdański, Wydział Chemii

Structural and functional analysis of immune checkpoints

Call: OPUS 13 , Panel: NZ1

Principal investigator: prof. Grzegorz Dubin

Uniwersytet Jagielloński, Małopolskie Centrum Biotechnologii Uniwersytetu Jagiellońskiego

Guardian of a cell cycle: role of HO-1 in HSC proliferation

Call: PRELUDIUM 13 , Panel: NZ1

Principal investigator: Monika Żukowska

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

Evaluation of the anticancer efficacy of a new chimeric antigen receptor targeting PD-L1 molecule

Call: OPUS 12 , Panel: NZ6

Principal investigator: dr hab. Radosław Zagożdżon

Warszawski Uniwersytet Medyczny, Wydział Lekarski

The role of arginase-1 in antitumor efficacy of cancer immunotherapy using checkpoint inhibitors

Call: OPUS 12 , Panel: NZ6

Principal investigator: prof. Dominika Anna Nowis

Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

Genotoxicity of antitumor compound 3-bromopyruvate in the yeast Saccharomyces cerevisiae.

Call: SONATA 9 , Panel: NZ2

Principal investigator: dr Magdalena Cal

Uniwersytet Wrocławski, Wydział Nauk Biologicznych