Genotoxicity of antitumor compound 3-bromopyruvate in the yeast Saccharomyces cerevisiae.
2015/17/D/NZ2/01985
Keywords
Descriptors
- NZ2_1: Genetyka molekularna
Panel
NZ2 – Genetics, genomics: molecular genetics, genomics, proteomics, bioinformatics, systems biology, genetic epidemiology
Host institution
Uniwersytet Wrocławski, Wydział Nauk Biologicznych
Voivodeship: dolnośląskie
Principal investigator (from the host institution)
Number of co-investigators in the project: 3
Call
SONATA 9 – announced on 2015-03-16
- Amount awarded
- 450 000 PLN
- Project start date
- 2016-03-07
- Project end date
- 2021-09-06
- Project duration
- 66 months (the same as in the proposal)
- Project status
- Project settled
Project description
Download the project description in a pdf file
Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Equipment purchased [PL]
- Laptop wraz z oprogramowaniem MS Office oraz OS Windows a także z dyskiem zewnętrznym. Cost: 3 500 PLN
- Mikroskop optyczny z możliwością obserwacji w kontraście fazowym wraz z kamerą. Cost: 40 000 PLN
- Termoblok z wytrząsaniem. Cost: 13 000 PLN
- Urządzenie archiwizujące - zestaw komputerowy.
- Zestaw do elektroforezy żelowej białek z wyposażeniem i modułem do transferu mokrego oraz z zasilaczem. Cost: 13 000 PLN
Information in the final report
Publication in academic press/journals (3)
-
Mitochondrial Function Are Disturbed in the Presence of the Anticancer Drug, 3-Bromopyruvate
- Authors:
- Magdalena Cal, Irwin Matyjaszczyk, Karolina Filik, Rafał Ogórek, Young Ko and Stanisław Ułaszewski
- Academic press:
- International Journal of Molecular Sciences (year: 2021, volume: 22, pages: 6640), Publisher: MDPI
- Status:
- Published
- DOI:
- 10.3390/ijms22126640 – link to the publication
-
The Anticancer Drug 3-Bromopyruvate Induces DNA Damage Potentially Through Reactive Oxygen Species in Yeast and in Human Cancer Cells
- Authors:
- Magdalena Cal, Irwin Matyjaszczyk, Ireneusz Litwin, Daria Augustyniak, Rafał Ogórek, Young Ko, Stanisław Ułaszewski
- Academic press:
- Cells (year: 2020, volume: 9, pages: 1161), Publisher: MDPI
- Status:
- Published
- DOI:
- 10.3390/cells9051161 – link to the publication
-
Glutathione may have implications in the design of 3-bromopyruvate treatment protocols for both fungal and algal infections as well as multiple myeloma
- Authors:
- Niedźwiecka K., Dyląg M., Augustyniak D., Majkowska-Skrobek G., Cal-Bąkowska M., Ko YH., Pedersen PL., Goffeau A., Ułaszewski S.
- Academic press:
- Oncotarget (year: 2016, volume: 40, pages: 65614-65626), Publisher: Oncotarget
- Status:
- Published
- DOI:
- 10.18632/oncotarget.11592 – link to the publication