Projects funded by the NCN
Evaluation of the anticancer efficacy of a new chimeric antigen receptor targeting PD-L1 molecule
2016/23/B/NZ6/02535
Keywords:
cancer chimeric antigen receptor CAR immune checkpoint PD-L1 adoptive therapy T lymphocytes NK cells synNotch strategy
Descriptors:
- NZ5_7: Human disease treatment
- NZ6_1: Adaptive and innate immunity
- NZ3_7: Signal transduction
Panel:
NZ6 - Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology
Host institution :
Warszawski Uniwersytet Medyczny, Wydział Lekarski
woj. mazowieckie
Principal investigator (from the host institution):
Number of co-investigators in the project: 4
Call: OPUS 12 - announced on 2016-09-15
Amount awarded: 1 688 480 PLN
Project start date (Y-m-d): 2017-07-10
Project end date (Y-m-d): 2021-01-09
Project duration:: 42 months (the same as in the proposal)
Project status: Project settled
Project description
Download the project description in a pdf file
Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Equipment purchased [PL]
- Cytometr FACSLyric wyposażony w trzy lasery (niebieski, czerwony,fioletowy), umożliwiający jednoczesny pomiar 8 fluorescencji (4/2/2) + FSC/SSC.
- Laser 561-nm do cytometru przepływowego (350 000 PLN)
Information in the final report
- Publication in academic press/journals (2)
- Targeting Negative and Positive Immune Checkpoints with Monoclonal Antibodies in Therapy of CancerAuthors:Katsiaryna Marhelava, Zofia Pilch, Malgorzata Bajor, Agnieszka Graczyk-Jarzynka, Radoslaw ZagozdzonAcademic press:Cancers (rok: 2019, tom: 11, strony: 1756), Wydawca: MDPIStatus:PublishedDOI:10.3390/cancers11111756 - link to the publication
- PD-L1 CAR effector cells induce self-amplifying cytotoxic effects against target cellsAuthors:Malgorzata Bajor, Agnieszka Graczyk-Jarzynka, Katsiaryna Marhelava, Anna Burdzinska, Angelika Muchowicz, Agnieszka Goral, Andriy Zhylko, Karolina Soroczynska, Kuba Retecki, Marta Krawczyk, Marta Klopotowska, Zofia Pilch, Leszek Paczek, Karl-Johan Malmberg, Sébastien Wälchli, Magdalena Winiarska,Radoslaw ZagozdzonAcademic press:Journal for ImmunoTherapy of Cancer , Wydawca: British Medical Journal / Society for Immunotherapy of CancerStatus:Accepted for publicationDOI:10.1136/ - link to the publication