Evaluation of the anticancer efficacy of a new chimeric antigen receptor targeting PD-L1 molecule
2016/23/B/NZ6/02535
Keywords
Descriptors
- NZ5_7: Leczenie chorób człowieka
- NZ6_1: Odporność swoista i nieswoista
- NZ3_7: Przekaźnictwo sygnału
Panel
NZ6 – Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology
Host institution
Warszawski Uniwersytet Medyczny, Wydział Lekarski
Voivodeship: mazowieckie
Principal investigator (from the host institution)
Number of co-investigators in the project: 4
Call
OPUS 12 – announced on 2016-09-15
- Amount awarded
- 1 688 480 PLN
- Project start date
- 2017-07-10
- Project end date
- 2021-01-09
- Project duration
- 42 months (the same as in the proposal)
- Project status
- Project settled
Project description
Download the project description in a pdf file
Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Equipment purchased [PL]
- Cytometr FACSLyric wyposażony w trzy lasery (niebieski, czerwony,fioletowy), umożliwiający jednoczesny pomiar 8 fluorescencji (4/2/2) + FSC/SSC.
- Laser 561-nm do cytometru przepływowego. Cost: 350 000 PLN
Information in the final report
Publication in academic press/journals (2)
-
Targeting Negative and Positive Immune Checkpoints with Monoclonal Antibodies in Therapy of Cancer
- Authors:
- Katsiaryna Marhelava, Zofia Pilch, Malgorzata Bajor, Agnieszka Graczyk-Jarzynka, Radoslaw Zagozdzon
- Academic press:
- Cancers (year: 2019, volume: 11, pages: 1756), Publisher: MDPI
- Status:
- Published
- DOI:
- 10.3390/cancers11111756 – link to the publication
-
PD-L1 CAR effector cells induce self-amplifying cytotoxic effects against target cells
- Authors:
- Malgorzata Bajor, Agnieszka Graczyk-Jarzynka, Katsiaryna Marhelava, Anna Burdzinska, Angelika Muchowicz, Agnieszka Goral, Andriy Zhylko, Karolina Soroczynska, Kuba Retecki, Marta Krawczyk, Marta Klopotowska, Zofia Pilch, Leszek Paczek, Karl-Johan Malmberg, Sébastien Wälchli, Magdalena Winiarska,Radoslaw Zagozdzon
- Status:
- Accepted for publication