Projects funded by the NCN

DNA repair pathways contributing to resistance to photodynamic therapy and as possible theraupeutic targets

Call: OPUS 8 , Panel: NZ5

Principal investigator: dr hab. Elżbieta Speina

Instytut Biochemii i Biofizyki PAN

Efficacy, toxicity and immunogenicity of carriers made of bioengineered spider silk for targeted drug delivery

Call: OPUS 8 , Panel: NZ7

Principal investigator: dr hab. Hanna Dams-Kozłowska

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, Wydział Medyczny

The role of bioactive sphingolipids: ceramide, ceramide-1-phosphate and sphingosine-1-phosphate in regulation of mitocho...

Call: OPUS 8 , Panel: NZ3

Principal investigator: dr hab. Robert Strosznajder

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

Identification of new, clinically relevant genetic and epigenetic aberrations by next-generation sequencing in chronic m...

Call: HARMONIA 6 , Panel: NZ5

Principal investigator: dr Tomasz Stokłosa

Warszawski Uniwersytet Medyczny, Wydział Lekarski

Physicochemical characterization of cyclodextrins tailored for pH-dependent targeted therapy with anthracycline drugs

Call: OPUS 7 , Panel: ST5

Principal investigator: prof. Renata Bilewicz

Uniwersytet Warszawski, Wydział Chemii

Nanozeolites as a carriers of radium radionuclides in targeted therapy.

Call: HARMONIA 1 , Panel: ST4

Principal investigator: prof. Aleksander Bilewicz

Instytut Chemii i Techniki Jądrowej

Combined targeted therapy with the use of PPAR receptor ligands or statins and cytostatics aimed at molecular mechanisms...

Call: SONATA 1 , Panel: NZ4

Principal investigator: dr Wojciech Placha

Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Lekarski

New drug carriers in targeted anticancer therapy

Call: OPUS 1 , Panel: ST5

Principal investigator: prof. Artur Terzyk

Uniwersytet Mikołaja Kopernika, Wydział Chemii

Nanoparticles of gold, gold-gold sulfide and titanium dioxide modified with tellurium as carriers for At-211 for targete...

Call: OPUS 6 , Panel: ST4

Principal investigator: prof. Aleksander Bilewicz

Instytut Chemii i Techniki Jądrowej

BCL11b - Potential Therapeutic Target in T cell Neoplasms

Call: OPUS 5 , Panel: NZ1

Principal investigator: dr hab. Grzegorz Przybylski

Instytut Genetyki Człowieka PAN

Cross-talk between PXR and AR receptors in hormone-dependent cancers.

Call: SONATA 5 , Panel: NZ7

Principal investigator: dr Magdalena Niemira

Politechnika Gdańska, Wydział Chemiczny

The role of poly(ADP-ribose) polymerase and sirtuins in molecular mechanism of cell death. Identification of novel targe...

Call: OPUS 5 , Panel: NZ3

Principal investigator: prof. Joanna Strosznajder

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

Characteristics of the cell wall hydrolases of pathogenic bacteria Listeria monocytogenes and their partcipation in the ...

Call: OPUS 5 , Panel: NZ6

Principal investigator: dr hab. Magdalena Popowska

Uniwersytet Warszawski, Wydział Biologii

Cancer progression- the role of tumor-derived microfragments (oncosomes) as messangers in communication between tumor ce...

Call: OPUS 4 , Panel: NZ6

Principal investigator: dr Rafał Szatanek

Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum, Wydział Lekarski

DNA double-stranded break repair proteins as a target for personalized cancer therapy based on synthetic lethality

Call: OPUS 4 , Panel: NZ7

Principal investigator: dr hab. Tomasz Śliwiński

Uniwersytet Łódzki, Wydział Biologii i Ochrony Środowiska

Identification of triple negative breast cancer with inactive DNA damage repair pathway by homologous recombination base...

Call: SONATA 3 , Panel: NZ5

Principal investigator: dr Paweł Domagała

Pomorski Uniwersytet Medyczny w Szczecinie, Wydział Lekarski z Oddziałem Nauczania w Języku Angielskim

Multitasking polymeric lattices included selected DNA oligonucleotide sequences - synthesis, modifications and physioche...

Call: SONATA 3 , Panel: ST5

Principal investigator: dr Ewelina Zabost

Uniwersytet Warszawski, Wydział Chemii

Regulation of ALKBH proteins expression in cancer and its role in cancer therapy.

Call: OPUS 2 , Panel: NZ4

Principal investigator: prof. Elżbieta Grzesiuk

Instytut Biochemii i Biofizyki PAN

Pathogenesis of ovarian cancer survival in non-adhesion conditions: transcriptomic assessment and studies of molecular t...

Call: PRELUDIUM 2 , Panel: NZ1

Principal investigator: dr Anna Stachurska

Centrum Onkologii - Instytut im. Marii Skłodowskiej-Curie

Mitochondrial targets of flozins in endothelial cells - a new approach to the prevention, diagnosis and therapy of heart...

Call: OPUS 26 , Panel: NZ4

Principal investigator: dr hab. Barbara Kutryb-Zając

Gdański Uniwersytet Medyczny, Wydział Lekarski

Modulation of protein interaction networks as a new therapeutic target in the treatment of hereditary retinal dystrophie...

Call: SONATA 19 , Panel: NZ5

Principal investigator: dr Xiaonan Liu

Śląski Uniwersytet Medyczny w Katowicach, Wydział Nauk Medycznych w Katowicach

Extensive analysis of the immunological profile of pediatric patients with acute lymphoblastic leukemia in order to iden...

Call: PRELUDIUM 22 , Panel: NZ5

Principal investigator: Anna Krętowska-Grunwald

Uniwersytet Medyczny w Białymstoku

Cuproptosis, a novel pathway of regulated cell death as a therapeutic target in treatment-naïve and targeted therapy-res...

Call: OPUS 25 , Panel: NZ5

Principal investigator: dr hab. Mariusz Hartman

Uniwersytet Medyczny w Łodzi, Wydział Lekarski

Targeting Energy Metabolism for Precision Cancer Therapy: Novel Inhibitors of LDH-A and PDK1 as Potential Strategies to ...

Call: PRELUDIUM 22 , Panel: NZ7

Principal investigator: Marika Frańczak

Gdański Uniwersytet Medyczny, Wydział Lekarski

EBI2 receptor as a new myelin repair therapy in multiple sclerosis.

Call: SONATA 18 , Panel: NZ3

Principal investigator: dr Aleksandra Rutkowska

Gdański Uniwersytet Medyczny, Centrum Chorób Mózgu

Targeted poloxamer micelles with selected drugs as a strategy for overcoming the mechanisms of multidrug resistance in p...

Call: PRELUDIUM BIS 4 , Panel: NZ7

Principal investigator: prof. Tomasz Gośliński

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu

Research on the preparation of new, hydrogel nanosystems for targeted therapy of colorectal cancer

Call: SONATA 18 , Panel: NZ7

Principal investigator: dr Urszula Piotrowska

Warszawski Uniwersytet Medyczny

Customized DNA-based nanocarriers to boost heart healing

Call: M-ERA.NET 3 Call 2022 , Panel: NZ7

Principal investigator: dr Monika Bzowska

Uniwersytet Jagielloński

Investigating the role of fibroblast growth factor receptors and STAT transcription factors in the targeted therapy of a...

Call: PRELUDIUM BIS 4 , Panel: NZ5

Principal investigator: prof. Ewa Marcinkowska

Uniwersytet Wrocławski, Wydział Biotechnologii

Molecular insights into hypoxic tumors – for development of targeted cancer therapeutics

Call: POLONEZ BIS 3 , Panel: NZ5

Principal investigator: dr Marco Deiana

Politechnika Wrocławska

Modifiers of Muscleblind-like genes expression in health and disease.

Call: SONATA BIS 12 , Panel: NZ5

Principal investigator: dr hab. Ewa Stępniak-Konieczna

Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Biologii

Synthesis of new phthalocyanines for targeted photodynamic cancer therapy.

Call: SONATA 2 , Panel: ST5

Principal investigator: dr Łukasz Łapok

Uniwersytet Jagielloński, Wydział Chemii, Zespół Nanotechnologii Polimerów i Biomateriałów

Bioconjugates of 103Pd nanostructures for targeted Auger electron therapy.

Call: OPUS 23 , Panel: ST5

Principal investigator: dr hab. Agnieszka Majkowska-Pilip

Instytut Chemii i Techniki Jądrowej

Perinuclear AKAP6 signalosome as a new target for gene therapy in ischemic optic neuropathy

Call: OPUS 22 , Panel: NZ4

Principal investigator: dr hab. Tomasz Boczek

Uniwersytet Medyczny w Łodzi, Wydział Nauk o Zdrowiu

Interleukin-18 receptor targeted gene therapy as a novel approach for the treatment of pulmonary hypertension using cont...

Call: POLONEZ BIS 1 , Panel: NZ5

Principal investigator: dr Tara Scott

Gdański Uniwersytet Medyczny, Wydział Lekarski

The role of NPM1 as biomarker of the targeted therapy efficacy in chronic lymphocytic leukemia patients

Call: PRELUDIUM BIS 3 , Panel: NZ5

Principal investigator: prof. Krzysztof Giannopoulos

Uniwersytet Medyczny w Lublinie, Wydział Lekarski

Light-producing, oxygen-delivering, cancer cell-targeted carriers for photosensitisers dedicated for photodynamic therap...

Call: OPUS 22 , Panel: NZ7

Principal investigator: prof. Marek Murias

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu

Studies on anti-inflammatory properties of GPR18 ligands and their involvement in modulation of microglia phenotypes – a...

Call: OPUS 22 , Panel: NZ7

Principal investigator: prof. Katarzyna Kieć-Kononowicz

Uniwersytet Jagielloński, Collegium Medicum

Searching for new therapeutic targets in polyglutamine diseases

Call: OPUS 22 , Panel: NZ2

Principal investigator: dr hab. Marta Olejniczak

Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

Chronic pain in obesity: from cellular mechanisms to new strategies for targeted therapy.

Call: SONATA 17 , Panel: NZ5

Principal investigator: dr Anna Piotrowska-Murzyn

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

FGFR2-->JunB axis in progression of ER+ breast cancer - molecular analyses and prognostication

Call: PRELUDIUM BIS 3 , Panel: NZ3

Principal investigator: dr hab. Rafał Sądej

Gdański Uniwersytet Medyczny, Międzyuczelniany Wydział Biotechnologii Uniwersytetu Gdańskiego i Gdańskiego Uniwersytetu Medycznego

Proline metabolism as a novel therapeutic target for diseases associated with mitochondrial dysfunction.

Call: SONATA BIS 11 , Panel: NZ3

Principal investigator: dr Karolina Szczepanowska

Międzynarodowy Instytut Mechanizmów i Maszyn Molekularnych Polskiej Akademii Nauk

Opioid receptors in the basal ganglia of the brain as targets for alcohol abuse therapy.

Call: OPUS 2 , Panel: NZ4

Principal investigator: dr Jan Rodriguez Parkitna

Instytut Farmakologii PAN

Synthetic epidermal growth factor receptor inhibitor conjugated with nobel metal nanoparticles as a potential drug for t...

Call: PRELUDIUM 20 , Panel: NZ7

Principal investigator: Shaoshan Mai

Gdański Uniwersytet Medyczny, Wydział Farmaceutyczny

Bioconjugates of gold nanoparticles coated by 197/197mHg for Auger electron targeted therapy

Call: PRELUDIUM 20 , Panel: ST5

Principal investigator: Emilia Majka

Instytut Chemii i Techniki Jądrowej

In search for molecular targets to overcome doxorubicin resistance in triple-negative breast cancer with the use of inno...

Call: PRELUDIUM 20 , Panel: NZ7

Principal investigator: Anna Pogorzelska

Narodowy Instytut Leków

Molecular and cellular landscape of pulmonary and hepatic metastases of colorectal cancer with potential clinical implic...

Call: PRELUDIUM 20 , Panel: NZ4

Principal investigator: Marta Popęda

Gdański Uniwersytet Medyczny, Wydział Lekarski

Aging-associated, specific pathomechanisms of endothelial dysfunction in sepsis: pathway analysis and experimental thera...

Call: WEAVE-UNISONO , Panel: NZ7

Principal investigator: prof. Stefan Karol Chłopicki

Uniwersytet Jagielloński

Identification of the interdependence between SWI/SNF-type chromatin remodeling complex, metabolism control and RNA modi...

Call: OPUS 20 , Panel: NZ5

Principal investigator: dr hab. Tomasz Sarnowski

Instytut Biochemii i Biofizyki Polskiej Akademii Nauk

Identification of surface proteins as alternate targets for CAR-T therapy against CD19-negative tumors.

Call: PRELUDIUM BIS 2 , Panel: NZ6

Principal investigator: dr hab. Magdalena Winiarska

Warszawski Uniwersytet Medyczny, Wydział Lekarski