Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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New insights into multifaceted targeted therapy for treatment of glioblastoma multiforme.

2019/35/B/NZ5/04208

Keywords:

glioblastoma multidirectional targeted therapy EGFR mTOR kinases

Descriptors:

  • NZ5_7: Human disease treatment
  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology
  • NZ3_7: Signal transduction

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Uniwersytet Śląski w Katowicach, Wydział Nauk Ścisłych i Technicznych

woj.

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Katarzyna Anna Malarz 

Number of co-investigators in the project: 5

Call: OPUS 18 - announced on 2019-09-16

Amount awarded: 1 954 800 PLN

Project start date (Y-m-d): 2020-07-20

Project end date (Y-m-d): 2025-07-19

Project duration:: 60 months (the same as in the proposal)

Project status: Pending project

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (25)
  1. Spectroscopic and biological properties of the 3-imino-1,8-naphthalimide derivatives as fluorophores for cellular imaging
    Authors:
    Mateusz Korzec, Sonia Kotowicz, Katarzyna Malarz, Anna Mrozek-Wilczkiewicz
    Academic press:
    Molecules (rok: 2023, tom: 28, strony: 15), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules28176255 - link to the publication
  2. 1,8-Naphthalimides 3-substituted with imine or β-ketoenamine unit evaluated as compounds for organic electronics and cell imaging
    Authors:
    M. Korzec, S. Kotowicz, R. Gawecki, K. Malarz, A. Mrozek-Wilczkiewicz, M. Siwy, E. Schab-Balcerzak, J. Grzelak, S. Maćkowski
    Academic press:
    Dyes and Pigments (rok: 2021, tom: 193, strony: 9), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.dyepig.2021.109508 - link to the publication
  3. 1,8-Naphthalimides 3-substituted with imine or β-ketoenamine unit evaluated as compounds for organic electronics and cell imaging
    Authors:
    M. Korzec, S. Kotowicz, R. Gawecki, K. Malarz, A. Mrozek-Wilczkiewicz, M. Siwy, E. Schab-Balcerzak, J. Grzelak, S. Maćkowski
    Academic press:
    Dyes and Pigments (rok: 2021, tom: 193, strony: 9), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.dyepig.2021.109508 - link to the publication
  4. Novel benzenesulfonate scaffolds with a high anticancer activity and G2/M cell cycle arrest
    Authors:
    K. Malarz, J. Mularski, M. Kuczak, A. Mrozek-Wilczkiewicz, R. Musiol
    Academic press:
    Cancers (rok: 2021, tom: 8, strony: 24), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cancers13081790 - link to the publication
  5. Imbalance of redox homeostasis and altered cellular signaling induced by the metal complexes of terpyridine
    Authors:
    Malarz K., Ziola P., Zych D., Rurka P., Mrozek-Wilczkiewicz A.
    Academic press:
    Scientific Reports (rok: 2024, tom: 14, strony: 26951), Wydawca: Nature Portfolio
    Status:
    Published
    DOI:
    10.1038/s41598-024-77575-4 - link to the publication
  6. 1,8-Naphthalimides 3-substituted with imine or β-ketoenamine unit evaluated as compounds for organic electronics and cell imaging
    Authors:
    M. Korzec, S. Kotowicz, R. Gawecki, K. Malarz, A. Mrozek-Wilczkiewicz, M. Siwy, E. Schab-Balcerzak, J. Grzelak, S. Maćkowski
    Academic press:
    Dyes and Pigments (rok: 2021, tom: 193, strony: 9), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.dyepig.2021.109508 - link to the publication
  7. Spectroscopic and biological properties of the 3-imino-1,8-naphthalimide derivatives as fluorophores for cellular imaging
    Authors:
    Mateusz Korzec, Sonia Kotowicz, Katarzyna Malarz, Anna Mrozek-Wilczkiewicz
    Academic press:
    Molecules (rok: 2023, tom: 28, strony: 15), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules28176255 - link to the publication
  8. Novel benzenesulfonate scaffolds with a high anticancer activity and G2/M cell cycle arrest
    Authors:
    K. Malarz, J. Mularski, M. Kuczak, A. Mrozek-Wilczkiewicz, R. Musiol
    Academic press:
    Cancers (rok: 2021, tom: 8, strony: 24), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cancers13081790 - link to the publication
  9. Identification and Biological Evaluation of a Water-Soluble Fullerene Nanomaterial as BTK Kinase Inhibitor
    Authors:
    Malarz K., Korzuch J., Marforio T.D., Balin K., Calvaresi M., Mrozek-Wilczkiewicz A., Musiol R., Serda M.
    Academic press:
    International Journal of Nanomedicine (rok: 2023, tom: 1, strony: 1), Wydawca: Dove Medical Press
    Status:
    Accepted for publication
  10. Anticancer potential and through study of the cytotoxicity mechanism of ionic liquids that are based on the trifluoromethanesulfonate and bis(trifluoromethylsulfonyl)imide anions
    Authors:
    M. Kuczak, M. Musiał, K. Malarz, P. Rurka, E. Zorębski, R. Musioł, M. Dzida, A. Mrozek-Wilczkiewicz
    Academic press:
    Journal of Hazardous Materials (rok: 2021, tom: 427, strony: 16), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jhazmat.2021.128160 - link to the publication
  11. Luminescence and Electrochemical Activity of New Unsymmetrical 3-Imino-1,8-naphthalimide Derivatives
    Authors:
    S. Kotowicz, M. Korzec, K. Malarz, A. Krystkowska, A. Mrozek-Wilczkiewicz, S. Golba, M. Siwy, S. Maćkowski, E. Schab-Balcerzak
    Academic press:
    Materials (rok: 2021, tom: 14, strony: 23), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ma14195504 - link to the publication
  12. Anticancer potential and through study of the cytotoxicity mechanism of ionic liquids that are based on the trifluoromethanesulfonate and bis(trifluoromethylsulfonyl)imide anions
    Authors:
    M. Kuczak, M. Musiał, K. Malarz, P. Rurka, E. Zorębski, R. Musioł, M. Dzida, A. Mrozek-Wilczkiewicz
    Academic press:
    Journal of Hazardous Materials (rok: 2021, tom: 427, strony: 16), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jhazmat.2021.128160 - link to the publication
  13. Spectroscopic and biological properties of 3-imino-1,8- naphthalimide derivatives as new fluorophores for cellular imaging
    Authors:
    Mateusz Korzec, Sonia Kotowicz, Katarzyna Malarz, Anna Mrozek-Wilczkiewicz
    Academic press:
    Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy (rok: 2023, tom: 1, strony: 24), Wydawca: Elsevier
    Status:
    Submitted
    DOI:
    link to the publication
  14. Novel benzenesulfonate scaffolds with a high anticancer activity and G2/M cell cycle arrest
    Authors:
    K. Malarz, J. Mularski, M. Kuczak, A. Mrozek-Wilczkiewicz, R. Musiol
    Academic press:
    Cancers (rok: 2021, tom: 8, strony: 24), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cancers13081790 - link to the publication
  15. 1,8-Naphthalimides 3-substituted with imine or β-ketoenamine unit evaluated as compounds for organic electronics and cell imaging
    Authors:
    M. Korzec, S. Kotowicz, R. Gawecki, K. Malarz, A. Mrozek-Wilczkiewicz, M. Siwy, E. Schab-Balcerzak, J. Grzelak, S. Maćkowski
    Academic press:
    Dyes and Pigments (rok: 2021, tom: 193, strony: 9), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.dyepig.2021.109508 - link to the publication
  16. Luminescence and Electrochemical Activity of New Unsymmetrical 3-Imino-1,8-naphthalimide Derivatives
    Authors:
    S. Kotowicz, M. Korzec, K. Malarz, A. Krystkowska, A. Mrozek-Wilczkiewicz, S. Golba, M. Siwy, S. Maćkowski, E. Schab-Balcerzak
    Academic press:
    Materials (rok: 2021, tom: 14, strony: 23), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ma14195504 - link to the publication
  17. Styrylquinazoline derivatives as ABL inhibitors selective for different DFG orientations
    Authors:
    Katarzyna Malarz, Jacek Mularski, Marcin Pacholczyk, Robert Musiol
    Academic press:
    Journal of Enzyme Inhibition and Medicinal Chemistry (rok: 2023, tom: 38, strony: 21), Wydawca: Taylor & Francis
    Status:
    Published
    DOI:
    10.1080/14756366.2023.2201410 - link to the publication
  18. Luminescence and Electrochemical Activity of New Unsymmetrical 3-Imino-1,8-naphthalimide Derivatives
    Authors:
    S. Kotowicz, M. Korzec, K. Malarz, A. Krystkowska, A. Mrozek-Wilczkiewicz, S. Golba, M. Siwy, S. Maćkowski, E. Schab-Balcerzak
    Academic press:
    Materials (rok: 2021, tom: 14, strony: 23), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ma14195504 - link to the publication
  19. Luminescence and Electrochemical Activity of New Unsymmetrical 3-Imino-1,8-naphthalimide Derivatives
    Authors:
    S. Kotowicz, M. Korzec, K. Malarz, A. Krystkowska, A. Mrozek-Wilczkiewicz, S. Golba, M. Siwy, S. Maćkowski, E. Schab-Balcerzak
    Academic press:
    Materials (rok: 2021, tom: 14, strony: 23), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ma14195504 - link to the publication
  20. Anticancer potential and through study of the cytotoxicity mechanism of ionic liquids that are based on the trifluoromethanesulfonate and bis(trifluoromethylsulfonyl)imide anions
    Authors:
    M. Kuczak, M. Musiał, K. Malarz, P. Rurka, E. Zorębski, R. Musioł, M. Dzida, A. Mrozek-Wilczkiewicz
    Academic press:
    Journal of Hazardous Materials (rok: 2021, tom: 427, strony: 16), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jhazmat.2021.128160 - link to the publication
  21. Identification and Biological Evaluation of a Water-Soluble Fullerene Nanomaterial as BTK Kinase Inhibitor
    Authors:
    Malarz K., Korzuch J., Marforio T.D., Balin K., Calvaresi M., Mrozek-Wilczkiewicz A., Musiol R., Serda M.
    Academic press:
    International Journal of Nanomedicine (rok: 2023, tom: 18, strony: 16), Wydawca: Dove Medical Press
    Status:
    Published
    DOI:
    10.2147/IJN.S403058 - link to the publication
  22. Styrylquinazoline derivatives as ABL inhibitors selective for different DFG orientations
    Authors:
    Katarzyna Malarz, Jacek Mularski, Marcin Pacholczyk, Robert Musiol
    Academic press:
    Journal of Enzyme Inhibition and Medicinal Chemistry (rok: 2023, tom: 38, strony: 21), Wydawca: Taylor & Francis
    Status:
    Published
    DOI:
    10.1080/14756366.2023.2201410 - link to the publication
  23. Identification and Biological Evaluation of a Water-Soluble Fullerene Nanomaterial as BTK Kinase Inhibitor
    Authors:
    Malarz K., Korzuch J., Marforio T.D., Balin K., Calvaresi M., Mrozek-Wilczkiewicz A., Musiol R., Serda M.
    Academic press:
    International Journal of Nanomedicine (rok: 2023, tom: 18, strony: 16), Wydawca: Dove Medical Press
    Status:
    Published
    DOI:
    10.2147/IJN.S403058 - link to the publication
  24. Novel benzenesulfonate scaffolds with a high anticancer activity and G2/M cell cycle arrest
    Authors:
    K. Malarz, J. Mularski, M. Kuczak, A. Mrozek-Wilczkiewicz, R. Musiol
    Academic press:
    Cancers (rok: 2021, tom: 8, strony: 24), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cancers13081790 - link to the publication
  25. Anticancer potential and through study of the cytotoxicity mechanism of ionic liquids that are based on the trifluoromethanesulfonate and bis(trifluoromethylsulfonyl)imide anions
    Authors:
    M. Kuczak, M. Musiał, K. Malarz, P. Rurka, E. Zorębski, R. Musioł, M. Dzida, A. Mrozek-Wilczkiewicz
    Academic press:
    Journal of Hazardous Materials (rok: 2021, tom: 427, strony: 16), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jhazmat.2021.128160 - link to the publication

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