Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Inhibitors of anti-apoptotic proteins from the BCL-2 family as agents enhancing BRAFV600E inhibition in melanoma cells.

2016/23/D/NZ7/03904

Keywords:

apoptosis BCL-2 proteins BH3 mimetics BRAF melanoma targeted therapy

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Medyczny w Łodzi, Międzywydziałowa Katedra Chemii i Biochemii Medycznej

woj. łódzkie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Mariusz Hartman 

Number of co-investigators in the project: 4

Call: SONATA 12 - announced on 2016-09-15

Amount awarded: 748 670 PLN

Project start date (Y-m-d): 2017-08-11

Project end date (Y-m-d): 2021-02-10

Project duration:: 42 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Urządzenie do wizualizacji blotów w oparciu o chemiluminescencję (130 000 PLN)

Information in the final report

  • Publication in academic press/journals (3)
  • Articles in post-conference publications (1)
  1. Non-Apoptotic cell death signaling pathways in melanoma
    Authors:
    Mariusz Lukasz Hartman
    Academic press:
    International Journal of Molecular Sciences (rok: 2020, tom: 21, strony: 2980), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21082980 - link to the publication
  2. BCL-w: apoptotic and non-apoptotic role in health and disease
    Authors:
    Mariusz Lukasz Hartman, Malgorzata Czyz
    Academic press:
    Cell Death & Disease (rok: 2020, tom: 11, strony: 260), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1038/s41419-020-2417-0 - link to the publication
  3. BH3 mimetics potentiate pro-apoptotic activity of encorafenib in BRAF V600E melanoma cells
    Authors:
    Mariusz Lukasz Hartman, Anna Gajos-Michniewicz, Julita Talaj, Aleksandra Mielczarek-Lewandowska, Malgorzata Czyz
    Academic press:
    Cancer Letters (rok: 2021, tom: 499, strony: 122-136), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.canlet.2020.11.036 - link to the publication
  1. Encorafenib alters melanoma cell proximity to the apoptotic threshold – implications for complementary therapeutic strategy using selective BH3 mimetics.
    Authors:
    Mariusz Lukasz Hartman, Anna Gajos-Michniewicz, Julita Talaj, Aleksandra Mielczarek-Lewandowska, Malgorzata Czyz
    Conference:
    24th Gliwice Scientific Meetings (rok: 2020, ), Wydawca: nie dotyczy
    Data:
    konferencja 20-21 listopada
    Status:
    Published

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