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Biokoniugaty radioaktywnych nanocząstek platyny do celowanej terapii elektronami Auger

2019/35/B/ST4/01433

Keywords:

nanoparticles Auger electrons targeted radionuclide therapy

Descriptors:

  • ST4_18: Radiation and nuclear chemistry
  • ST5_10: Functional materials/nanomaterials, nanoparticles
  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology

Panel:

ST4 - Chemistry: physical chemistry/chemical physics, theoretical chemistry, analytical chemistry, inorganic chemistry, organic chemistry, method development

Host institution :

Instytut Chemii i Techniki Jądrowej

woj.

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Aleksander Józef Bilewicz 

Number of co-investigators in the project: 4

Call: OPUS 18 - announced on 2019-09-16

Amount awarded: 1 268 400 PLN

Project start date (Y-m-d): 2020-08-12

Project end date (Y-m-d): 2024-08-11

Project duration:: 48 months (the same as in the proposal)

Project status: Project completed

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (7)
  1. Challenging production of Auger electron emitter platinum-195m via double- -neutron capture activation of an iridium-193 target
    Authors:
    Kamil Wawrowicz, A. Bilewicz ,
    Academic press:
    Bio- -Algorithms and Med-Systems (rok: 2023, tom: 19, strony: 35-39), Wydawca: De Gruyter
    Status:
    Published
    DOI:
    10.5604/01.3001.0054.1821 - link to the publication
  2. Platinum nanoparticles labelled with iodine-125 for combined chemo-Auger electron" therapy of hepatocellular carcinoma
    Authors:
    Kamil Wawrowicz, Kinga Zelechowska-Matysiak, Agnieszka MajkowskaPilip, Mateusz Wierzbicki , Aleksander Bilewicz
    Academic press:
    Nanoscale Advance (rok: 2023, tom: 5, strony: 3293-3303), Wydawca: Royal Societ of Chemistry
    Status:
    Published
    DOI:
    10.1039/d3na00165b - link to the publication
  3. Oxidative Status as an Attribute for Selective Antitumor Activity of Platinum-Containing Nanoparticles against Hepatocellular Carcinoma
    Authors:
    Kamil Wawrowicz, Agnieszka Majkowska-Pilip, Marzena Szwed, Kinga Żelechowska-Matysiak, Ewelina Chajduk, Aleksander Bilewicz
    Academic press:
    International Journal of Molecular Science (rok: 2022, tom: 23, strony: 14773), Wydawca: MPDI
    Status:
    Published
    DOI:
    10.3390/ - link to the publication
  4. Nanostructures as Radionuclide Carriers in Auger Electron Therapy
    Authors:
    NasrinAbbasi Gharibkandi, Joanna Gierałtowska, Kamil Wawrowicz, Aleksander Bilewicz
    Academic press:
    Materials (rok: 2022, tom: 2022, 15(3), 1143;, strony: 1143-1163), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ma15031143 - link to the publication
  5. Au@Pt Core-Shell Nanoparticle Bioconjugates for the Therapy of HER2+ Breast Cancer and Hepatocellular Carcinoma. Model Studies on the Applicability of 193mPt and 195mPt Radionuclides in Auger Electron Therapy
    Authors:
    KamilWawrowicz ,Agnieszka Majkowska-Pilip,Damian Gaweł, Ewelina Chajduk, Tadeusz Pienkowski, Aleksander Bilewicz
    Academic press:
    Molecules (rok: 2021, tom: 26, strony: 2051), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ - link to the publication
  6. Oxidative Status as an Attribute for Selective Antitumor Activity of Platinum-Containing Nanoparticles against Hepatocellular Carcinoma
    Authors:
    Kamil Wawrowicz, Agnieszka Majkowska-Pilip, Marzena Szwed, Kinga Żelechowska-Matysiak, Ewelina Chajduk, Aleksander Bilewicz
    Academic press:
    International Journal of Molecular Science (rok: 2022, tom: 23, strony: 14773), Wydawca: MPDI
    Status:
    Published
    DOI:
    10.3390/ - link to the publication
  7. Radiobiokoniugaty znakowane emiterami elektronów augera w celowanej terapii radionuklidowej
    Authors:
    Kamil Wawrowicz, Aleksander Bilewicz
    Academic press:
    Wiadomości Chemiczne (rok: 2020, tom: 74,, strony: 699-733), Wydawca: Polskie Towarzystwo Chemiczne
    Status:
    Published

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