Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Nanomolecular antioxidants: biological basis of targeted therapy of neurodegenerative diseases.

2016/22/E/NZ7/00641

Keywords:

nano-antioxidants oxidative stress neurodegenerative diseases

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology
  • NZ5_7: Human disease treatment
  • NZ3_6: Cell neurobiology

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Rzeszowski, Kolegium Nauk Przyrodniczych

woj. podkarpackie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Izabela Sadowska-Bartosz 

Number of co-investigators in the project: 6

Call: SONATA BIS 6 - announced on 2016-06-15

Amount awarded: 1 668 800 PLN

Project start date (Y-m-d): 2017-03-27

Project end date (Y-m-d): 2023-12-26

Project duration:: 81 months (the same as in the proposal)

Project status: Project completed

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (12)
  • Articles in post-conference publications (1)
  1. Possible Artefacts of Antioxidant Assays Performed in the Presence of Nitroxides and Nitroxide-containing Nanoparticles
    Authors:
    Monika Pichla, Grzegorz Bartosz, Natalia Pieńkowska, Izabela Sadowska-Bartosz
    Academic press:
    Analytical Biochemistry (rok: 2020, tom: 597, strony: 113698), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ab.2020.113698 - link to the publication
  2. The Antiaggregative and Antiamyloidogenic Properties of Nanoparticles: A Promising Tool for the Treatment and Diagnostics of Neurodegenerative Diseases
    Authors:
    Pichla M, Bartosz G, Sadowska-Bartosz I.
    Academic press:
    Oxidative Medicine and Cellular Longevity (rok: 2020, tom: 2020, strony: 3534570), Wydawca: Hindawi
    Status:
    Published
    DOI:
    10.1155/2020/3534570 - link to the publication
  3. Nitroxide radicals-containing redox nanoparticles protect neuroblastoma SH-SY5Y cells against 6-hydroxydopamine toxicity
    Authors:
    Monika Pichla, Lukasz Pulaski, Katarzyna Dominika Kania, I. Stefaniuk, Bogumil Cieniek, Natalia Pienkowska, Grzegorz Bartosz, and Izabela Sadowska-Bartosz
    Academic press:
    Oxidative Medicine and Cellular Longevity (rok: 2020, tom: 2020, strony: 9260748), Wydawca: Hindawi
    Status:
    Published
    DOI:
    10.1155/2020/9260748 - link to the publication
  4. The Cellular and Organismal Effects of Nitroxides and Nitroxide-Containing Nanoparticles
    Authors:
    Sadowska-Bartosz I., Bartosz G.
    Academic press:
    International Journal of Molecular Sciences (rok: 2024, tom: 25,, strony: 1446), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms25031446 - link to the publication
  5. Effect of 6-hydroxydopamine increase the glutathione level in SH-SY5Y human neuroblastoma cells
    Authors:
    Pieńkowska N, Bartosz G, Sadowska-Bartosz I.
    Academic press:
    Acta Biochim Polonica (rok: 2023, tom: 70(2), strony: 457-464), Wydawca: Polskie Towarzystwo Biochemiczne
    Status:
    Published
    DOI:
    10.18388/abp.2020_6847 - link to the publication
  6. Tempo-phosphate as an ESR tool to study phosphate transport
    Authors:
    Sadowska-Bartosz I, Stefaniuk I, Cieniek B, Bartosz G
    Academic press:
    Free Radical Research (rok: 2018, tom: 52(3), strony: 335-338), Wydawca: Taylor & Francis
    Status:
    Published
    DOI:
    10.1080/10715762.2017.1400163 - link to the publication
  7. Effect of Low Concentration of Nitroxides on SH-SY5Y Cells Transfected with the Tau Protein
    Authors:
    Bartosz G., Pieńkowska N., Kut K., Cieniek B., Stefeniuk I., Sadowska-Bartosz I.
    Academic press:
    International Journal of Molecular Sciences (rok: 2023, tom: 24(23), strony: 16675), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms242316675 - link to the publication
  8. Induction of Oxidative Stress in SH-SY5Y Cells by Overexpression of hTau40 and Its Mitigation by Redox-Active Nanoparticles
    Authors:
    Natalia Pieńkowska, Margaret Fahnestock, Crystal Mahadeo, Izabela Zaborniak, Paweł Chmielarz, Grzegorz Bartosz, Izabela Sadowska-Bartosz
    Academic press:
    International Journal of Molecular Sciences (rok: 2022, tom: 24 (1), strony: 359), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms24010359 - link to the publication
  9. pH-Responsive Redox Nanoparticles Protect SH-SY5Y Cells at Lowered pH in a Cellular Model of Parkinson's Disease.
    Authors:
    Pichla M, Bartosz G, Stefaniuk I, Sadowska-Bartosz I.
    Academic press:
    Molecules (rok: 2021, tom: 26(3), strony: 543), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules26030543 - link to the publication
  10. Redox nanoparticles: synthesis, properties and perspectives of use for treatment of neurodegenerative diseases
    Authors:
    Sadowska-Bartosz I, Bartosz G
    Academic press:
    Journal of Nanobiotechnology (rok: 2018, tom: 16(1), strony: 87), Wydawca: BioMed Central
    Status:
    Published
    DOI:
    10.1186/s12951-018-0412-8 - link to the publication
  11. Origin and pathophysiology of protein carbonylation, nitration and chlorination in age-related brain diseases and aging
    Authors:
    Gonos ES, Kapetanou M, Sereikaite J, Bartosz G, Naparło K, Grzesik M, Sadowska-Bartosz I
    Academic press:
    Aging (Albany NY) (rok: 2018, tom: 10(5), strony: 868-901), Wydawca: Aging
    Status:
    Published
    DOI:
    10.18632/aging.101450 - link to the publication
  12. Nitroxide-containing amphiphilic polymers prepared by simplified electrochemically mediated ATRP as candidates for therapeutic antioxidants.
    Authors:
    Zaborniak I, Pieńkowska N, Chmielarz P, Bartosz G, Dziedzic A, Sadowska-Bartosz I.
    Academic press:
    Polymer (rok: 2023, tom: 273, strony: 125885,), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.polymer.2023.125885 - link to the publication
  1. Nitroxide radical-containing redox nanoparticles protect neuroblastoma SH-SY5Y cells against 6- hydroxydopamine toxicity
    Authors:
    Monika Pichla, Łukasz Pułaski, Katarzyna D. Kania, Ireneusz Stefaniuk, Bogumił Cieniek, Natalia Pieńkowska, Grzegorz Bartosz, Izabela Sadowska-Bartosz*
    Conference:
    Free Radical Research Europe (SFRR-E) Annual Meeting Abstracts Redox biology in the 21st century: a new scientific discipline" 15-18 June 2021, Belgrade, Serbia (rok: 2021, ), Wydawca: Elsevier
    Data:
    konferencja 2021-06-15-18
    Status:
    Published
    DOI:
    link to the publication

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