Projects funded by the NCN

Halogen bonding - the role and significance in interactions of ligands with class A GPCRs

Call: SONATA 8 , Panel: NZ7

Principal investigator: dr Rafał Kurczab

Instytut Farmakologii PAN

Unusual 5-HT6 receptor ligands

Call: OPUS 7 , Panel: NZ7

Principal investigator: prof. Andrzej Bojarski

Instytut Farmakologii PAN

Aromatase and estrogen receptors gene expression in human testicular tissues with normal and impaired spermatogensis

Call: OPUS 7 , Panel: NZ4

Principal investigator: prof. Krzysztof Kula

Uniwersytet Medyczny w Łodzi, Wydział Lekarski

Synthesis and biological evaluation of pyrrolidine-2,5-dione derivatives as potential antidepressant agents.

Call: OPUS 5 , Panel: NZ7

Principal investigator: dr Andrzej Chodkowski

Warszawski Uniwersytet Medyczny, Wydział Farmaceutyczny z Oddziałem Medycyny Laboratoryjnej

Development of a tool for automatic evaluation of complexes of ligands with serotonin receptors based on the application...

Call: PRELUDIUM 5 , Panel: NZ2

Principal investigator: Sabina Podlewska

Instytut Farmakologii PAN

Obtaining of new quinoline derivatives with potential activity for serotonin receptors and inhibition of serotonin reupt...

Call: PRELUDIUM 5 , Panel: NZ7

Principal investigator: Przemysław Taciak

Warszawski Uniwersytet Medyczny, Wydział Farmaceutyczny z Oddziałem Medycyny Laboratoryjnej

Cooperative involvement of serotonergic signaling and extracellular matrix in synaptic plasticity underlying the pathoge...

Call: HARMONIA 3 , Panel: NZ3

Principal investigator: dr hab. Jakub Włodarczyk

Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

The group III metabotropic glutamate receptors as a target for future antypsychotic drugs

Call: MAESTRO 3 , Panel: NZ7

Principal investigator: prof. Andrzej Pilc

Instytut Farmakologii PAN

Effect of paroxetine and risperidone on the heterodimerization of dopamine D2 and serotonin 5-HT1A receptor in the conte...

Call: PRELUDIUM 3 , Panel: NZ7

Principal investigator: dr Magdalena Kolasa

Instytut Farmakologii PAN

In the search for active compounds among ligands of serotonin, particularly 5-HT7, and dopamine receptors, with potentia...

Call: OPUS 1 , Panel: NZ4

Principal investigator: prof. Anna Wesołowska

Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

Probing the selectivity of zinc allosteric modulation in various serotonin receptor subtypes

Call: PRELUDIUM 3 , Panel: NZ7

Principal investigator: Grzegorz Satała

Instytut Farmakologii PAN

Targeting the serotonin 5-HT7 receptor in a search for new strategies of mental disorders treatment

Call: PRELUDIUM 22 , Panel: NZ7

Principal investigator: Patryk Pyka

Uniwersytet Jagielloński, Collegium Medicum

Combination of FAAH inhibition with action via serotonin 5-HT6 receptor as pioneering approach to fight with Alzheimer D...

Call: PRELUDIUM 21 , Panel: NZ7

Principal investigator: Kinga Czarnota-Łydka

Uniwersytet Jagielloński, Collegium Medicum

Role of peroxisome proliferator-activated receptors (PPARs) and free fatty acid receptors (FFARs) in androgen-dependent ...

Call: PRELUDIUM 21 , Panel: NZ3

Principal investigator: Joanna Cyran-Gryboś

Uniwersytet Jagielloński, Wydział Biologii

First-in-class dual biased agonists of serotonin 5-HT1A and dopamine D2 receptors – an innovative approach in the search...

Call: OPUS 21 , Panel: NZ7

Principal investigator: prof. Marcin Kołaczkowski

Uniwersytet Jagielloński, Collegium Medicum

Expression and function of Regulator of G Protein Signaling (RGS) proteins in physiological and pathophysiological condi...

Call: SONATA 16 , Panel: NZ7

Principal investigator: dr hab. Maciej Sałaga

Uniwersytet Medyczny w Łodzi

New 5-HT6 receptor ligands from the group of sulfonamide derivatives of cyclic arylguanidines in the treatment of gliobl...

Call: PRELUDIUM 19 , Panel: NZ7

Principal investigator: Przemysław Zaręba

Politechnika Krakowska im. Tadeusza Kościuszki, Wydział Inżynierii i Technologii Chemicznej

Thymol-derived 1,3,5-triazines, the non-indole and non-sulfone 5-HT6 receptor ligands, as a starter in search for an inn...

Call: OPUS 16 , Panel: NZ7

Principal investigator: prof. Jadwiga Handzlik

Uniwersytet Jagielloński – Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

Novel hybrid 5-HT6 serotonin receptor and SERT transporter ligands as a therapeutic perspective of behavioural and cogni...

Call: SONATA 14 , Panel: NZ7

Principal investigator: dr Agata Siwek

Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

Development of a group of non-basic ligands of serotonin receptor 5-HT7, derivatives of 2-(6-oxo-3-phenyl-1,6-dihydropyr...

Call: SONATINA 2 , Panel: NZ7

Principal investigator: dr Sabina Podlewska

Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

Anilide derivatives of long-chain cyclic amines as multifunctional serotonin receptors ligands and phosphodiesterase 7 i...

Call: PRELUDIUM 13 , Panel: NZ7

Principal investigator: dr Agnieszka Jankowska

Uniwersytet Jagielloński – Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

The determination of ADME-Tox in vitro for potential CNS-drug candidates acting as potent and selective ligands of serot...

Call: PRELUDIUM 11 , Panel: NZ7

Principal investigator: Annamaria Lubelska

Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

Searching for the new lead structures for 5-HT7 serotonin receptor ligands with increased metabolic stability.

Call: HARMONIA 7 , Panel: NZ7

Principal investigator: Sabina Podlewska

Instytut Farmakologii PAN

Changes in neurogenesis during withdrawal from nicotine self-administration in rats - role of serotonin (5-HT)2C recepto...

Call: OPUS 9 , Panel: NZ4

Principal investigator: dr Magdalena Zaniewska

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

Traizine 5-HT6 receptor ligands - new perspective for therapy of current civilization CNS-diseases

Call: OPUS 9 , Panel: NZ7

Principal investigator: dr hab. Jadwiga Handzlik

Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny