Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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The determination of ADME-Tox in vitro for potential CNS-drug candidates acting as potent and selective ligands of serotonin receptors 5-HT6

2016/21/N/NZ7/03265

Keywords:

parameters ADME-Tox drug- like properties CNS diseases Alzheimer's disease depression obesity

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology
  • NZ7_15: Toxicology
  • NZ4_11: Metabolism

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Annamaria Lubelska 

Number of co-investigators in the project: 3

Call: PRELUDIUM 11 - announced on 2016-03-15

Amount awarded: 99 260 PLN

Project start date (Y-m-d): 2017-04-14

Project end date (Y-m-d): 2019-10-13

Project duration:: 30 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Worteks V-1 Plus (874 PLN)
  2. wirówka laboratoryjna (3 500 PLN)
  3. Rotor SR-32 (188 PLN)
  4. Worteks Combi-Spin (OT/42/2019) (1 562 PLN)

Information in the final report

  • Publication in academic press/journals (3)
  1. Computer-Aided Studies for Novel Arylhydantoin 1,3,5-Triazine Derivatives as 5-HT6 Serotonin Receptor Ligands with Antidepressive-Like, Anxiolytic and Antiobesity Action In Vivo
    Authors:
    Rafał Kurczab, Wesam Ali, Dorota Łażewska, Magdalena Kotańska, Magdalena Jastrzębska-Więsek, Grzegorz Satała, Małgorzata Więcek, Annamaria Lubelska, Gniewomir Latacz, Anna Partyka, Małgorzata Starek, Monika Dąbrowska, Anna Wesołowska, Claus Jacob, Katarzyna Kieć-Kononowicz, Jadwiga Handzlik
    Academic press:
    Molecules (rok: 2018, tom: 23, strony: 2529), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules23102529 - link to the publication
  2. Synthesis and computer-aided SAR studies for derivatives of phenoxyalkyl-1,3,5-triazine as the new potent ligands for serotonin receptors 5-HT6
    Authors:
    Wesam Ali, Małgorzata Więcek, Dorota Łażewska, Rafał Kurczab, Magdalena Jastrzębska-Więsek, Grzegorz Satała, Katarzyna Kucwaj-Brysz, Annamaria Lubelska, Monika Głuch-Lutwin, Barbara Mordyl, Agata Siwek, Muhammad Jawad Nasim, Anna Partyka, Gniewomir Latacz, Anna Wesołowska, Katarzyna Kieć-Kononowicz, Jadwiga Handzlik
    Academic press:
    European Journal of Medicinal Chemistry (rok: 2019, tom: 178, strony: 740-751), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ejmech.2019.06.022 - link to the publication
  3. The 1,3,5-Triazine Derivatives as Innovative Chemical Family of 5-HT6 Serotonin Receptor Agents with Therapeutic Perspectives for Cognitive Impairment
    Authors:
    Gniewomir Latacz, Annamaria Lubelska, Magdalena Jastrzębska-Więsek, Anna Partyka, Małgorzata Anna Marć, Grzegorz Satała, Daria Wilczyńska, Magdalena Kotańska, Małgorzata Więcek, Katarzyna Kamińska, Anna Wesołowska, Katarzyna Kieć-Kononowicz, Jadwiga Handzlik
    Academic press:
    International Journal of Molecular Sciences (rok: 2019, tom: 20, strony: 45312), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms20143420 - link to the publication

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