Projects funded by the NCN
Targeting the serotonin 5-HT7 receptor in a search for new strategies of mental disorders treatment
2023/49/N/NZ7/02144
Keywords:
5-HT7 serotonin receptor antagonists of 5-HT7R longchain arylpiperazines hydantoin derivatives quinoxaline-2,3-diones mental disorders depression anxiety.
Descriptors:
- NZ7_14:
- ST5_13:
Panel:
NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology
Host institution :
Uniwersytet Jagielloński, Collegium Medicum
woj. małopolskie
Principal investigator (from the host institution):
Number of co-investigators in the project: 3
Call: PRELUDIUM 22 - announced on 2023-03-16
Amount awarded: 209 840 PLN
Project start date (Y-m-d): 2024-01-17
Project end date (Y-m-d): 2027-01-16
Project duration:: 36 months (the same as in the proposal)
Project status: Pending project
Project description
Download the project description in a pdf file
Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Information in the final report
- Publication in academic press/journals (1)
- Unlocking the potential of higher-molecular-weight 5-HT7R ligands: Synthesis, affinity, and ADMET examinationAuthors:Patryk Pyka, Sabrina Garbo, Aleksandra Murzyn, Grzegorz Satała, Artur Janusz, Michał Górka, Wojciech Pietruś, Filip Mituła, Delfina Popiel, Maciej Wieczorek, Biagio Palmisano, Alessia Raucci, Andrzej J. Bojarski, Clemens Zwergel, Ewa Szymańska, Katarzyna Kucwaj-Brysz, Cecilia Battistelli, Jadwiga Handzlik , Sabina PodlewskaAcademic press:Bioorganic Chemistry (rok: 2024, tom: 151, strony: 46042), Wydawca: ElsevierStatus:PublishedDOI:10.1016/j.bioorg.2024.107668 - link to the publication