Projects funded by the NCN

Comprehensive analysis of the therapeutic potential of oligonucleotides for the treatment of polyglutamine diseases

Call: SONATA 9 , Panel: NZ5

Principal investigator: dr hab. Agnieszka Fiszer

Instytut Chemii Bioorganicznej PAN

Fluorescent oligonucleotide probes based on i-motif structures with use cytosine analogue tC

Call: PRELUDIUM 8 , Panel: ST4

Principal investigator: Patrycja Bielecka

Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Chemii

Oligonucleotide-based fluorescent probes at the lipid monolayer / aqueous solution interface. Monitoring of the concentr...

Call: OPUS 1 , Panel: ST4

Principal investigator: prof. Bernard Juskowiak

Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Chemii

The use of chemically modified antisense oligonucleotides in the experimental therapy against Myotonic Dystrophy (DM).

Call: OPUS 8 , Panel: NZ5

Principal investigator: dr Ewa Stepniak-Konieczna

Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Biologii

RNA hybrid duplex-quadruplex structures with dual functionality as a new tool for silecing of gene expression

Call: OPUS 7 , Panel: ST5

Principal investigator: prof. Zofia Gdaniec

Instytut Chemii Bioorganicznej PAN

Vitamin B12 as a delivery vehicle for antibacterial oligonucleotide analogues

Call: SYMFONIA 2 , Panel: ST5

Principal investigator: dr hab. Dorota Gryko

Instytut Chemii Organicznej PAN

Polymeric stationary phases containing gold and silver nanoparticles in analytics of biologically active compounds

Call: PRELUDIUM 6 , Panel: ST4

Principal investigator: Damian Grzywiński

Uniwersytet Mikołaja Kopernika, Wydział Chemii

Exploring the Mutual Interactions between RNA Enantiomers

Call: PRELUDIUM 6 , Panel: NZ1

Principal investigator: Marta Dudek

Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

Modified chlorophyll derivatives and its RNA hybrid conjugates for modern photomedicine

Call: PRELUDIUM 6 , Panel: NZ7

Principal investigator: Michał Kotkowiak

Politechnika Poznańska, Wydział Fizyki Technicznej

Studies on biosensor's receptor layers composed of oligonucleotides

Call: PRELUDIUM 1 , Panel: ST4

Principal investigator: Robert Ziółkowski

Politechnika Warszawska, Wydział Chemiczny

Structure defined oligonucleotides for revealing fundamental insights into structure and function of RNAs

Call: MAESTRO 4 , Panel: ST5

Principal investigator: prof. Ryszard Kierzek

Instytut Chemii Bioorganicznej PAN

Conserved RNA structural motifs in influenza virus: toward revealing viral RNA functions

Call: HARMONIA 4 , Panel: NZ1

Principal investigator: dr hab. Elżbieta Kierzek

Instytut Chemii Bioorganicznej PAN

Designing mRNA transcripts resistant to enzymatic cap hydrolysis applicable for anti-cancer vaccines; multiplexed bioche...

Call: MAESTRO 4 , Panel: NZ1

Principal investigator: prof. Edward Darżynkiewicz

Uniwersytet Warszawski, Centrum Nowych Technologii

Members of eIF4E protein family, their affinities towards 5' mRNA cap and protein binding partners: an interdisciplinary...

Call: OPUS 4 , Panel: NZ1

Principal investigator: prof. Edward Darżynkiewicz

Uniwersytet Warszawski, Wydział Fizyki

Multitasking polymeric lattices included selected DNA oligonucleotide sequences - synthesis, modifications and physioche...

Call: SONATA 3 , Panel: ST5

Principal investigator: dr Ewelina Zabost

Uniwersytet Warszawski, Wydział Chemii

New approaches towards modulating selective and functional activities of antisense oligonucleotides

Call: OPUS 2 , Panel: ST5

Principal investigator: prof. Ryszard Kierzek

Instytut Chemii Bioorganicznej PAN

Feel the chemistry if you're close enough - proximity-induced SuFEx ligation for mRNA biology and medicine

Call: OPUS 25 , Panel: ST5

Principal investigator: prof. Jacek Jemielity

Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

P-stereodefined phosphorothioate analogs of 'morpholino" oligonucleotides (sTMO) as a new model of therapeutic nucleic a...

Call: SONATA 17 , Panel: ST4

Principal investigator: dr Katarzyna Jastrzębska

Centrum Badań Molekularnych i Makromolekularnych Polskiej Akademii Nauk

Role of antisense oligonucleotide-induced intronic microRNA on axonal morphogenesis in zebrafish

Call: SONATA 17 , Panel: NZ3

Principal investigator: dr Savani Anbalagan

Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Biologii

Antiviral strategies targeting RNA: Triplex forming peptide nucleic acids (PNA) and their small molecule conjugates spec...

Call: OPUS 21 , Panel: NZ1

Principal investigator: prof. Elżbieta Kierzek

Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

Anti-cancer strategy based on the induced G-quadruplex formation. Structural and biological properties of ligand-RNA/mRN...

Call: SONATA 16 , Panel: ST4

Principal investigator: dr Dorota Gudanis

Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

Modulation of immune cells activity in the tumor microenvironment by oligonucleotide therapeutics delivered by silk nano...

Call: OPUS 19 , Panel: NZ6

Principal investigator: dr hab. Hanna Dams-Kozłowska

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu

Lanthanide binding oligonucleotides (LBOs) as paramagnetic tags for NMR spectroscopy of nucleic acids

Call: OPUS 19 , Panel: ST4

Principal investigator: dr Witold Andrałojć

Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

Making use of siderophore transport systems to deliver peptide nucleic acids to bacterial cells

Call: OPUS 19 , Panel: NZ1

Principal investigator: prof. Joanna Trylska

Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

Foldback triplex-forming oligonucleotides as novel tools for G-quadruplex unfolding and selective inhibition of c-Myc on...

Call: OPUS 19 , Panel: NZ7

Principal investigator: dr hab. Anna Pasternak

Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

Antisense oligonucleotides and their nanostructures conjugated with boron clusters; physico-chemical and biological char...

Call: ETIUDA 8 , Panel: ST4

Principal investigator: Damian Kaniowski

Centrum Badań Molekularnych i Makromolekularnych Polskiej Akademii Nauk

Chasing the HARE: elucidation of the binding mechanism of the new and unexplored ligandsof the Hyaluronic Acid Receptor ...

Call: SONATINA 4 , Panel: NZ1

Principal investigator: dr Aleksandra Twarda-Cłapa

Politechnika Łódzka, Wydział Biotechnologii i Nauk o Żywności

Bacterial toxin-antitoxin systems as novel target for the development of potential antibiotics

Call: PRELUDIUM 13 , Panel: NZ1

Principal investigator: dr Marcin Równicki

Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

Synthesis and structural studies of oligonucleotides with tRNA anticodon stem-loop sequences containing newly discovered...

Call: OPUS 13 , Panel: ST5

Principal investigator: prof. Elżbieta Sochacka

Politechnika Łódzka, Wydział Chemiczny

Structural determinants of anticancer properties of G-rich oligonucleotides

Call: OPUS 13 , Panel: NZ7

Principal investigator: dr hab. Anna Pasternak

Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

Cotranscriptional folding of influenza virus RNA in MDCK cells in presence of antisense oligonucleotides. A new method f...

Call: OPUS 13 , Panel: NZ1

Principal investigator: prof. Ryszard Kierzek

Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

The puzzling fate of lupin chromosomes

Call: PRELUDIUM 12 , Panel: NZ2

Principal investigator: Wojciech Bielski

Instytut Genetyki Roślin Polskiej Akademii Nauk

Identification of novel structural variants in patients presenting with congenital limb malformations by means of the ge...

Call: PRELUDIUM 12 , Panel: NZ2

Principal investigator: dr Magdalena Socha

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, Wydział Lekarski

Application of new type of adsorbents and liquid chromatography hyphenated with mass spectrometry for the in vitro metab...

Call: SONATA BIS 6 , Panel: ST4

Principal investigator: dr hab. Sylwia Studzińska

Uniwersytet Mikołaja Kopernika, Wydział Chemii

Bifunctional antisense oligonucleotides - optimization of alternative splicing regulation in cancer cell lines

Call: SONATA 11 , Panel: NZ5

Principal investigator: dr Jolanta Lisowiec-Wąchnicka

Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

Double stranded probes, in which both oligonucleotide components hybridize according to the Hoogsteen's interactions, an...

Call: OPUS 10 , Panel: ST5

Principal investigator: dr hab. Piotr Guga

Centrum Badań Molekularnych i Makromolekularnych Polskiej Akademii Nauk

Anticoagulant and antiproliferative properties of novel thrombin binding aptamer analogues

Call: PRELUDIUM 10 , Panel: NZ5

Principal investigator: Weronika Kotkowiak

Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

Chromatographic determination of nucleic acids (DNA, RNA) and their constituents (nucleosides, nucleotides, oligonuceoti...

Call: SONATA 1 , Panel: ST4

Principal investigator: dr Sylwia Studzińska

UNIWERSYTET MIKOŁAJA KOPERNIKA, Wydział Chemii, Katedra Chemii Środowiska i Bioanalityki

Interaction of oligonucleotide-based fluorescent probes and Langmuir monolayer, contaning silver nanoclusters (Ag NCs), ...

Call: PRELUDIUM 10 , Panel: ST4

Principal investigator: Angelika Świtalska

Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Chemii

In vivo and in vitro structure of influenza virus RNA. The structural determinants behind the inhibition of influenza vi...

Call: OPUS 10 , Panel: NZ1

Principal investigator: prof. Elżbieta Kierzek

Instytut Chemii Bioorganicznej Polskiej Akademii Nauk