Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Structural determinants of anticancer properties of G-rich oligonucleotides

2017/25/B/NZ7/00127

Keywords:

oligonucleotides G-quadruplexes nucleolin cancer proliferation thermodynamics RNA DNA

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology
  • NZ7_16: Other related subjects

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Anna Pasternak 

Number of co-investigators in the project: 4

Call: OPUS 13 - announced on 2017-03-15

Amount awarded: 1 290 900 PLN

Project start date (Y-m-d): 2018-01-30

Project end date (Y-m-d): 2022-01-29

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. koncentrator próżniowy z wymrażaczem, pompą próżniową i rotorami (86 000 PLN)
  2. kasety z ekranami do fosforimigera (25 000 PLN)
  3. zasilacz do elektroforezy (10 000 PLN)
  4. pompa olejowa wysokiej próźni (10 000 PLN)
  5. Spektrofotometr UV-VIS typu NanoDrop.
  6. wyparka obrotowa z pompą próżniową (40 000 PLN)
  7. zestaw komputerowy (5 500 PLN)

Information in the final report

  • Publication in academic press/journals (9)
  1. Beyond G-Quadruplexes—The Effect of Junction with Additional Structural Motifs on Aptamers Properties
    Authors:
    Weronika Kotkowiak, Anna Pasternak
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22(18), strony: 9948), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22189948 - link to the publication
  2. A systematic study on the influence of thermodynamic asymmetry of 5′-ends of siRNA duplexes in relation to their silencing potency
    Authors:
    Lisowiec-Wąchnicka J., Bartyś N., Pasternak A.
    Academic press:
    Scientific Reports (rok: 2019, tom: 9, strony: 45303), Wydawca: Nature Research
    Status:
    Published
    DOI:
    10.1038/s41598-018-36620-9 - link to the publication
  3. G-Quadruplex-Forming Aptamers-Characteristics, Applications, and Perspectives
    Authors:
    C. Roxo, W. Kotkowiak, A. Pasternak
    Academic press:
    Molecules (rok: 2019, tom: 24, strony: 3781), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules24203781 - link to the publication
  4. A Comprehensive Analysis of the Thrombin Binding Aptamer Containing Functionalized Pyrrolo-2'-deoxycytidines
    Authors:
    Weronika Kotkowiak, Zofia Jahnz-Wechmann, Anna Pasternak
    Academic press:
    Pharmaceuticals (rok: 2021, tom: 14(12), strony: 1326), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ph14121326 - link to the publication
  5. G4 Matters—The Influence of G-Quadruplex Structural Elements on the Antiproliferative Properties of G-Rich Oligonucleotides
    Authors:
    Carolina Roxo, Weronika Kotkowiak, Anna Pasternak
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22(9), strony: 4941), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22094941 - link to the publication
  6. Gapmer antisense oligonucleotides containing 2',3'-dideoxy-2'-fluoro-3'-C-hydroxymethyl-β-D-lyxofuranosyl nucleotides display site-specific RNase H cleavage and induce gene silencing
    Authors:
    M.B. Danielsen, C. Lou, J. Lisowiec-Wachnicka, A. Pasternak, P.T. Jørgensen, J. Wengel
    Academic press:
    Chemistry - A European Journal (rok: 2020, tom: 26, strony: 1368-1379), Wydawca: Wiley Online Library
    Status:
    Published
    DOI:
    10.1002/chem.201904540 - link to the publication
  7. Contribution of 3′T and 3′TT overhangs to the thermodynamic stability of model siRNA duplexes
    Authors:
    Lisowiec-Wąchnicka J., Znosko B., Pasternak A.
    Academic press:
    Biophysical Chemistry (rok: 2019, tom: 246, strony: 35–39), Wydawca: ELSEVIER SCIENCE BV
    Status:
    Published
    DOI:
    10.1016/j.bpc.2018.12.006 - link to the publication
  8. Improved RE31 analogues containing modified nucleic acid monomers: thermodynamic, structural and biological effects
    Authors:
    W. Kotkowiak, J. Wengel, C. Scotton, A. Pasternak
    Academic press:
    Journal of Medicinal Chemistry (rok: 2019, tom: 62, strony: 2499-2507), Wydawca: ACS
    Status:
    Published
    DOI:
    10.1021/acs.jmedchem.8b01806 - link to the publication
  9. Novel isoguanine derivative of unlocked nucleic acid - investigations of thermodynamics and biological potential of modified thrombin binding aptamer
    Authors:
    Kotkowiak W., Czapik T., Pasternak A.
    Academic press:
    PLoS ONE (rok: 2018, tom: 13(5), strony: e0197835), Wydawca: Public Library of Science
    Status:
    Published
    DOI:
    10.1371/journal.pone.0197835 - link to the publication

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