Projects funded by the NCN

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35 projects found matching your search criteria :

  1. New nucleotide analogs containing triazole within oligophosphate bridge as mimics of the 5' end of mRNA - synthesis, pro...

    Call: PRELUDIUM 9 , Panel: ST5

    Principal investigator: Sylwia Ciechanowicz

    Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

  2. Studies on the synthesis of newly discovered cyclic N6-threonylcarbamoyladenosine (ct6A) and its analogues and on the in...

    Call: PRELUDIUM 7 , Panel: ST5

    Principal investigator: Michał Matuszewski

    Politechnika Łódzka, Wydział Chemiczny

  3. Chemical syntesis and evaluation of biochemical properties of 7-methyloguanosine 5'-diphosphate analogs as inhibitors of...

    Call: PRELUDIUM 1 , Panel: NZ1

    Principal investigator: Marcin Ziemniak

    Uniwersytet Warszawski, Wydział Fizyki

  4. Biosynthesis of seleno-modified nucleosides in the anticodon loop of transfer ribonucleic acids. Evaluation of the enzym...

    Call: OPUS 7 , Panel: ST5

    Principal investigator: prof. Barbara Nawrot

    Centrum Badań Molekularnych i Makromolekularnych Polskiej Akademii Nauk

  5. Synthesis, biological and biophysical evaluation of mRNA cap-peptide conjugates for targeted delivery of cap analogues t...

    Call: OPUS 6 , Panel: ST5

    Principal investigator: dr hab. Marzena Jankowska-Anyszka

    Uniwersytet Warszawski, Wydział Chemii

  6. Thermodynamic insights into design of functionally optimized modified siRNAs and their experimental verification.

    Call: SONATA BIS 3 , Panel: NZ1

    Principal investigator: dr hab. Anna Pasternak

    Instytut Chemii Bioorganicznej PAN

  7. New methods for mRNA 5' end labeling and examples of their application in studies on RNA metabolism and searching for in...

    Call: OPUS 5 , Panel: ST5

    Principal investigator: dr hab. Jacek Jemielity

    Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

  8. Transformation of 5'-O-monothiophosphate nucleoside to 5'-O-monophosphate in the cell - possible metabolism of phosphoro...

    Call: OPUS 5 , Panel: ST5

    Principal investigator: dr Agnieszka Krakowiak

    Centrum Badań Molekularnych i Makromolekularnych Polskiej Akademii Nauk

  9. Synthesis and study of spectroscopic and bilogical properties of nucleosides modyfied by new stilbene derivatives

    Call: OPUS 4 , Panel: ST5

    Principal investigator: dr hab. Przemysław Szczeciński

    Politechnika Warszawska, Wydział Chemiczny

  10. Pronucloetides - a pathway to cellular DNA sensitization to ionizing radiation

    Call: PRELUDIUM 4 , Panel: ST5

    Principal investigator: Magdalena Zdrowowicz

    Uniwersytet Gdański, Wydział Chemii

  11. Development of chemical method for synthesis of biologically active triphosphates using thermolabile protecting groups

    Call: OPUS 4 , Panel: ST5

    Principal investigator: dr hab. Marcin Chmielewski

    Instytut Chemii Bioorganicznej PAN

  12. New 3,8-disubstituted purine nucleoside analogues as prospective application for research of structure and biological ac...

    Call: SONATA 3 , Panel: ST5

    Principal investigator: dr hab. Anna Pasternak

    Instytut Chemii Bioorganicznej PAN

  13. Influence of nucleotide sequence on the yield of radio- and photodamage to double stranded DNA fragments labelled with t...

    Call: OPUS 3 , Panel: ST5

    Principal investigator: prof. Janusz Rak

    Uniwersytet Gdański, Wydział Chemii

  14. Adenosine 5'-phosphoramidate as a novel signaling molecule; Study of enzymatic synthesis of this nucleotide and analysis...

    Call: OPUS 3 , Panel: NZ1

    Principal investigator: prof. Andrzej Guranowski

    Uniwersytet Przyrodniczy w Poznaniu, Wydział Rolnictwa i Bioinżynierii

  15. New reagents and methods in synthesis of modified nucleotides and their application for preparation biochemical tools an...

    Call: SONATA BIS 1 , Panel: ST5

    Principal investigator: dr hab. Jacek Jemielity

    Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

  16. Conjugates of cap analogs with nanomaterials and biomolecules with potential applications in pharmacology or diagnostics

    Call: SONATA 1 , Panel: ST5

    Principal investigator: dr Joanna Kowalska

    Uniwersytet Warszawski, Wydział Fizyki

  17. Stereodefined phosphorothioate analogs of DNA with incorporated LNA-type nucleosides - synthesis and properties of compl...

    Call: OPUS 2 , Panel: ST5

    Principal investigator: dr hab. Piotr Guga

    Centrum Badań Molekularnych i Makromolekularnych PAN

  18. Feel the chemistry if you're close enough - proximity-induced SuFEx ligation for mRNA biology and medicine

    Call: OPUS 25 , Panel: ST5

    Principal investigator: prof. Jacek Jemielity

    Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

  19. Modified (oligo)nucleotides for photo-controlled manipulation of mRNA

    Call: SONATA 18 , Panel: ST4

    Principal investigator: dr Marcin Warmiński

    Uniwersytet Warszawski, Wydział Fizyki

  20. Synthesis and structural/biophysical studies of model mRNA/mt-tRNA oligomers to evaluate the role of modified nucleoside...

    Call: OPUS 22 , Panel: ST4

    Principal investigator: dr hab. Grażyna Leszczyńska

    Politechnika Łódzka

  21. mRNA 5' end methylation status: towards deeper understanding of biological role and identification of synthetic mimics

    Call: OPUS 17 , Panel: ST4

    Principal investigator: dr hab. Jacek Jemielity

    Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

  22. Exploring second generation of nucleotide analogues containing phosphoranesulfen- or phosphoraneselenamides as new struc...

    Call: PRELUDIUM 16 , Panel: ST5

    Principal investigator: dr Justyna Gołębiewska

    Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

  23. Synthesis and characterization of new molecular probes for monitoring activity of enzymes associated with RNA decapping ...

    Call: OPUS 16 , Panel: ST5

    Principal investigator: dr hab. Joanna Kowalska

    Uniwersytet Warszawski, Wydział Fizyki

  24. Why Nature introduced selenium to wobble nucleosides in transfer RNA?

    Call: OPUS 15 , Panel: ST5

    Principal investigator: prof. Barbara Nawrot

    Centrum Badań Molekularnych i Makromolekularnych Polskiej Akademii Nauk

  25. Functional glycol nucleic acid (fun-GNA) nucleosides, nucleotides and oligos: synthesis and properties

    Call: OPUS 15 , Panel: ST5

    Principal investigator: prof. Konrad Kowalski

    Uniwersytet Łódzki, Wydział Chemii

  26. The role of extracellular ATP fraction in induction of epithelial-mesenchymal transition - studies using analogs of nucl...

    Call: SONATA 13 , Panel: ST5

    Principal investigator: dr Róża Pawłowska

    Centrum Badań Molekularnych i Makromolekularnych Polskiej Akademii Nauk

  27. Synthesis of trimethyl cap analogs modified with molecular rotors and their application in nuclear transport studies

    Call: SONATA 13 , Panel: ST5

    Principal investigator: dr Błażej Wojtczak

    Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

  28. Synthesis and structural studies of oligonucleotides with tRNA anticodon stem-loop sequences containing newly discovered...

    Call: OPUS 13 , Panel: ST5

    Principal investigator: prof. Elżbieta Sochacka

    Politechnika Łódzka, Wydział Chemiczny

  29. N-Oxide phosphobetaines in new synthetic strategies for P-modified phosphates and polyphospates of natural biomolecules ...

    Call: PRELUDIUM 12 , Panel: ST5

    Principal investigator: Magdalena Materna

    Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

  30. Chemically modified mRNA for studies on cellular processes and therapeutic applications

    Call: OPUS 11 , Panel: ST5

    Principal investigator: prof. Jacek Jemielity

    Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

  31. Fluorescent biosensors based on quantum dots and purines/pyrimidines - synthesis, characterization and potential applica...

    Call: PRELUDIUM 11 , Panel: ST5

    Principal investigator: Łucja Rodzik-Czałka

    Uniwersytet Jagielloński, Wydział Fizyki, Astronomii i Informatyki Stosowanej

  32. Pro-nucleotides based on mRNA cap structure - synthesis, biological and biophysical evaluation

    Call: SONATA 11 , Panel: ST5

    Principal investigator: dr Karolina Piecyk

    Uniwersytet Warszawski, Wydział Chemii

  33. Purine salvage pathway enzymes as a target for pathogenic organisma lacking de novo purine synthesis -cas study of Helic...

    Call: HARMONIA 7 , Panel: NZ1

    Principal investigator: prof. Maria Bzowska

    Uniwersytet Warszawski, Wydział Fizyki

  34. Synthesis and evaluation of a novel toolkit for biology and biotechnology based on adenine nucleotides analogs

    Call: SONATA BIS 5 , Panel: ST5

    Principal investigator: dr hab. Joanna Kowalska

    Uniwersytet Warszawski, Wydział Fizyki

  35. Aryl nucleoside phosphoroamidates - a new generation of anti-HIV pronucleotides.

    Call: OPUS 1 , Panel: ST5

    Principal investigator: prof. Jacek Stawiński

    Instytut Chemii Bioorganicznej PAN

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