Projects funded by the NCN

The role of simultaneous and individual modulation of μ-opioid, sigma-1 and histamine H3 receptors as a new therapeutic ...

Call: OPUS 23 , Panel: NZ7

Principal investigator: dr Katarzyna Szczepańska

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

Crystallographic analysis of RNA-ligand complexes. Towards rational design oflead compounds for development of therapies...

Call: OPUS 23 , Panel: NZ7

Principal investigator: dr hab. Agnieszka Kiliszek

Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

Allosteric and allosteric-orthosteric bitopic ligands of histamine receptor H4 as a way to increase selectivity and bias...

Call: OPUS 23 , Panel: NZ7

Principal investigator: prof. Sławomir Filipek

Uniwersytet Warszawski, Wydział Chemii

Metallosupramolecular architectures based on flexidentate pyridyl-β-diketonate ligands - synthesis, properties and catal...

Call: PRELUDIUM 21 , Panel: ST4

Principal investigator: Gracjan Kurpik

Uniwersytet im. Adama Mickiewicza w Poznaniu, Centrum Zaawansowanych Technologii

Novel tricyclic glycomimetics as DC-SIGN receptor ligands.

Call: OPUS 22 , Panel: ST4

Principal investigator: dr Mykhaylo Potopnyk

Instytut Chemii Organicznej Polskiej Akademii Nauk

Development of the knowledge on the role of GPR18 ligands as a microglia-targeted strategy in the regulation of neuroinf...

Call: SONATA 17 , Panel: NZ3

Principal investigator: dr Ewelina Honkisz-Orzechowska

Uniwersytet Jagielloński, Collegium Medicum

NanoBioCat: Developing biopolymer-based and protein friendly ionic liquids assisted enzyme nano-constructs with improved...

Call: SONATA 17 , Panel: ST4

Principal investigator: dr Dibyendu Mondal

Instytut Genetyki Roślin Polskiej Akademii Nauk

Targeting cell surface proteoglycans with high affinity multimeric ligands and their cytotoxic conjugates – towards prec...

Call: OPUS 22 , Panel: NZ1

Principal investigator: dr hab. Łukasz Opaliński

Uniwersytet Wrocławski, Wydział Biotechnologii

Studies on anti-inflammatory properties of GPR18 ligands and their involvement in modulation of microglia phenotypes – a...

Call: OPUS 22 , Panel: NZ7

Principal investigator: prof. Katarzyna Kieć-Kononowicz

Uniwersytet Jagielloński, Collegium Medicum

Research of multifunctional compounds targeting neuroinflammation and cholinergic deficit in Alzheimer's disease

Call: OPUS 22 (LAP) , Panel: NZ7

Principal investigator: prof. Kinga Sałat

Uniwersytet Jagielloński, Collegium Medicum

Reversible modulation of G-quadruplex functions using photoresponsive ligands - in vitro and cellular studies

Call: SONATA 17 , Panel: ST4

Principal investigator: dr Marta Dudek

Politechnika Wrocławska

The interplay of neurochemistry and cancer biology: in the search for novel glioblastoma multiforme therapy among dopami...

Call: SONATA 17 , Panel: NZ7

Principal investigator: dr Katarzyna Kucwaj-Brysz

Uniwersytet Jagielloński, Collegium Medicum

True Bioisosteres - Structural and Thermodynamic Classification of Molecular Fragments for Ligand Design

Call: SONATA BIS 11 , Panel: ST4

Principal investigator: dr Maura Malińska

Uniwersytet Warszawski, Wydział Chemii

Combating addiction by targeting α3β4*-nicotinic acetylcholine receptors

Call: OPUS 21 , Panel: NZ7

Principal investigator: dr Ákos Nemecz

Uniwersytet Mikołaja Kopernika w Toruniu, Wydział Nauk Biologicznych i Weterynaryjnych

Impact of hydrological regimes on the quantitive and qualitative optical properties of dissolved organic matter in West ...

Call: OPUS 21 , Panel: ST10

Principal investigator: dr Monika Zabłocka

Instytut Oceanologii Polskiej Akademii Nauk

Antiviral strategies targeting RNA: Triplex forming peptide nucleic acids (PNA) and their small molecule conjugates spec...

Call: OPUS 21 , Panel: NZ1

Principal investigator: prof. Elżbieta Kierzek

Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

First-in-class dual biased agonists of serotonin 5-HT1A and dopamine D2 receptors – an innovative approach in the search...

Call: OPUS 21 , Panel: NZ7

Principal investigator: prof. Marcin Kołaczkowski

Uniwersytet Jagielloński, Collegium Medicum

Wood from pine family (Pinaceae) native to Poland as a potent source of pharmacologically active lignans

Call: PRELUDIUM 20 , Panel: NZ7

Principal investigator: Andrzej Patyra

Warszawski Uniwersytet Medyczny, Wydział Farmaceutyczny

Advanced coordination materials designed on the basis of functional silsesquioxanes

Call: OPUS 21 , Panel: ST5

Principal investigator: dr hab. Beata Dudziec

Uniwersytet im. Adama Mickiewicza w Poznaniu, Centrum Zaawansowanych Technologii

Assessing protein-ligand complexes with ML/DL models trained on molecular dynamics-based descriptors.

Call: OPUS 20 , Panel: ST4

Principal investigator: dr hab. Paweł Siedlecki

Instytut Biochemii i Biofizyki Polskiej Akademii Nauk

AXL receptor signaling in cancer cell growth and drug resistance

Call: OPUS 20 , Panel: NZ3

Principal investigator: prof. Marta Miączyńska

Międzynarodowy Instytut Biologii Molekularnej i Komórkowej w Warszawie

Photodynamics of metal complexes with 2,6-bis(thiazol-2-yl)pyridine derivatives functionalized by aryls and N-donors as ...

Call: SONATA 16 , Panel: ST4

Principal investigator: dr Anna Maroń

Uniwersytet Śląski w Katowicach, Wydział Nauk Ścisłych i Technicznych

Multifunctional character of copper(II) macrocyclic complexes – utilization in atom transfer radical polymerization (ATR...

Call: SONATA 16 , Panel: ST4

Principal investigator: dr Adam Gorczyński

Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Chemii

The new methodology for better understanding of ligand-RNA interactions.

Call: OPUS 20 , Panel: NZ2

Principal investigator: dr Filip Stefaniak

Międzynarodowy Instytut Biologii Molekularnej i Komórkowej w Warszawie

Silsesquioxanes as Multifunctional Ligands in Coordination Chemistry and Nano-Building Blocks for Hybrid Materials

Call: OPUS 20 , Panel: ST4

Principal investigator: dr hab. Łukasz John

Uniwersytet Wrocławski, Wydział Chemii

New therapies of opioid use disorder

Call: OPUS 20 , Panel: NZ7

Principal investigator: dr Wojciech Solecki

Uniwersytet Jagielloński, Wydział Zarządzania i Komunikacji Społecznej

Nanoengineering of multicomponent metal-free carbonaceous materials for bio-oil upgrading through ultrasound-assisted se...

Call: OPUS 20 , Panel: ST5

Principal investigator: dr hab. Juan Colmenares Quintero

Instytut Chemii Fizycznej Polskiej Akademii Nauk

Anti-cancer strategy based on the induced G-quadruplex formation. Structural and biological properties of ligand-RNA/mRN...

Call: SONATA 16 , Panel: ST4

Principal investigator: dr Dorota Gudanis

Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

Input of the structure of influenza A virus RNA on regulation of virus proliferation. High throughput screening of small...

Call: OPUS 20 , Panel: NZ1

Principal investigator: prof. Elżbieta Kierzek

Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

The influence of environment on biomolecular function, structure and interactions.

Call: SONATA BIS 10 , Panel: ST4

Principal investigator: dr hab. Piotr Setny

Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

New 5-HT6 receptor ligands from the group of sulfonamide derivatives of cyclic arylguanidines in the treatment of gliobl...

Call: PRELUDIUM 19 , Panel: NZ7

Principal investigator: Przemysław Zaręba

Politechnika Krakowska im. Tadeusza Kościuszki, Wydział Inżynierii i Technologii Chemicznej

Investigation into the mechanism of regulation of nicotinic acetylcholine receptors

Call: POLS , Panel: NZ3

Principal investigator: dr Ákos Nemecz

Uniwersytet Mikołaja Kopernika w Toruniu, Wydział Nauk Biologicznych i Weterynaryjnych

New multifunctional drug-like ligands focusing on molecular targets associated with the symptoms and causes of Alzheimer...

Call: PRELUDIUM 19 , Panel: NZ7

Principal investigator: Anna Pasieka

Uniwersytet Jagielloński, Collegium Medicum

Novel approach in the search for asthma and COPD therapies - computer aided design of multi-target-directed ligands bloc...

Call: PRELUDIUM 19 , Panel: NZ7

Principal investigator: Alicja Gawalska

Uniwersytet Jagielloński, Collegium Medicum

Interconversions of supramolecular architectures based on Schiff base ligands and transition metal ions as potential pro...

Call: PRELUDIUM 19 , Panel: ST4

Principal investigator: Martyna Szymańska

Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Chemii

Structure-function relationship in fibroblast growth factor signaling

Call: CEUS-UNISONO , Panel: NZ3

Principal investigator: dr hab. Małgorzata Urszula Zakrzewska

Uniwersytet Wrocławski

Combined administration of muscarinic receptor antagonists and group II/III metabotropic glutamate (mGlu) receptor ligan...

Call: OPUS 19 , Panel: NZ7

Principal investigator: prof. Andrzej Pilc

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

Dual histamine H3 and sigma-1 receptor ligands as novel pharmacological tools in the treatment of central nervous system...

Call: SONATINA 4 , Panel: NZ7

Principal investigator: Katarzyna Szczepańska

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

Role of the Intersubunit and Interdomain Interactions in the GABAA Receptor Modulation by Protons.

Call: ETIUDA 8 , Panel: NZ1

Principal investigator: Michał Michałowski

Uniwersytet Wrocławski, Wydział Nauk Biologicznych

Chasing the HARE: elucidation of the binding mechanism of the new and unexplored ligandsof the Hyaluronic Acid Receptor ...

Call: SONATINA 4 , Panel: NZ1

Principal investigator: dr Aleksandra Twarda-Cłapa

Politechnika Łódzka, Wydział Biotechnologii i Nauk o Żywności

Research on the impact of pyrolysis technological parameters and substrate properties on the release of volatile organic...

Call: PRELUDIUM BIS 1 , Panel: ST8

Principal investigator: dr hab. Andrzej Białowiec

Uniwersytet Przyrodniczy we Wrocławiu, Wydział Przyrodniczo-Technologiczny

Do potential new MRGPRX2 ligands induce mastocytes degranulation in human?

Call: OPUS 18 , Panel: NZ5

Principal investigator: dr hab. Grzegorz Porębski

Uniwersytet Jagielloński, Collegium Medicum

Seeking for CB1 and CB2 receptor ligands among drugs, drug metabolites, and phytochemical compounds

Call: PRELUDIUM 18 , Panel: NZ7

Principal investigator: Adam Stasiulewicz

Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

Supported Ionic Liquid Phase materials based on oxide composites and lignin as new catalytic systems in hydrosilylation ...

Call: PRELUDIUM 18 , Panel: ST4

Principal investigator: Olga Bartlewicz

Fundacja Uniwersytetu im. Adama Mickiewicza w Poznaniu

Histamine H3/H4 receptors as the attractive target for the search of biologically active substances

Call: MAESTRO 1 , Panel: NZ4

Principal investigator: prof. Katarzyna Kieć-Kononowicz

Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

MXO2-ISOMER: in search of colour-changing photoswitchable materials based on 4th-row transition-metal complexes with sim...

Call: PRELUDIUM BIS 1 , Panel: ST4

Principal investigator: dr hab. Katarzyna Jarzembska

Uniwersytet Warszawski, Wydział Chemii

Molecular mechanisms of interplay between RORγ/RORγT receptors and cyclin-dependent kinase inhibitor (AT7519). Analysis ...

Call: PRELUDIUM 18 , Panel: NZ7

Principal investigator: Kaja Karaś

Instytut Biologii Medycznej Polskiej Akademii Nauk

Analysis of the conformations of organic compounds in macromolecular structures

Call: PRELUDIUM 18 , Panel: ST6

Principal investigator: Joanna Macnar

Uniwersytet Warszawski, Wydział Chemii

Binding isotope effects as new, unique tool for studies of receptor - ligand interactions

Call: MAESTRO 1 , Panel: ST4

Principal investigator: prof. Piotr Paneth

POLITECHNIKA ŁÓDZKA

In search of new metalloporphyrinoid catalysts for functionalization of C(sp3)-H bonds

Call: SONATA 15 , Panel: ST4

Principal investigator: dr Karolina Hurej

Uniwersytet Wrocławski, Wydział Chemii