Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Input of the structure of influenza A virus RNA on regulation of virus proliferation. High throughput screening of small molecules towards inhibition of influenza virus replication.

2020/39/B/NZ1/03054

Keywords:

RNA structure influenza A virus replication inhibition small molecules high-throughput screening

Descriptors:

  • NZ1_1: Molecular biology
  • NZ1_4: Structural biology
  • NZ2_7: Bioinformatics

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

woj.

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Elżbieta Beata Kierzek 

Number of co-investigators in the project: 7

Call: OPUS 20 - announced on 2020-09-15

Amount awarded: 2 452 810 PLN

Project start date (Y-m-d): 2021-09-01

Project end date (Y-m-d): 2025-08-31

Project duration:: 48 months (the same as in the proposal)

Project status: Pending project

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (8)
  1. A Test and Refinement of Folding Free Energy Nearest Neighbor Parameters for RNA Including N6-Methyladenosine
    Authors:
    M. Szabat, M. Prochota, R. Kierzek, E. Kierzek, D. H. Mathews
    Academic press:
    Journal of Molecular Biology (rok: 2022, tom: 434, strony: 167632), Wydawca: Elsevier Ltd
    Status:
    Published
    DOI:
    10.1016/j.jmb.2022.167632 - link to the publication
  2. Structural and Functional RNA Motifs of SARS-CoV-2 and Influenza A Virus as a Target of Viral Inhibitors
    Authors:
    I. Szczesniak, A. Baliga-Gil, A. Jarmolowicz, M. Soszynska-Jozwiak, E. Kierzek
    Academic press:
    International Journal of Molecular Sciences (rok: 2023, tom: 24, strony: 1232), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms24021232 - link to the publication
  3. Structural variants and modifications of hammerhead ribozymes targeting influenza A virus conserved structural motifs
    Authors:
    T. Czapik, J. Piasecka, R. Kierzek, E. Kierzek
    Academic press:
    Molecular Therapy - Nucleic Acids (rok: 2022, tom: 29, strony: 64-74), Wydawca: Cell Press
    Status:
    Published
    DOI:
    10.1016/j.omtn.2022.05.035 - link to the publication
  4. A Test and Refinement of Folding Free Energy Nearest Neighbor Parameters for RNA Including N6-Methyladenosine
    Authors:
    M. Szabat, M. Prochota, R. Kierzek, E. Kierzek, D. H. Mathews
    Academic press:
    Journal of Molecular Biology (rok: 2022, tom: 434, strony: 167632), Wydawca: Elsevier Ltd
    Status:
    Published
    DOI:
    10.1016/j.jmb.2022.167632 - link to the publication
  5. In vivo secondary structural analysis of Influenza A virus genomic RNA
    Authors:
    B. Mirska, T. Woźniak, D. Lorent, A. Ruszkowska, J. M. Peterson, W. N. Moss, D. H. Mathews, R. Kierzek, E. Kierzek
    Academic press:
    Cellular and Molecular Life Sciences (rok: 2023, tom: 80, strony: 136), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00018-023-04764-1 - link to the publication
  6. Structural variants and modifications of hammerhead ribozymes targeting influenza A virus conserved structural motifs
    Authors:
    T. Czapik, J. Piasecka, R. Kierzek, E. Kierzek
    Academic press:
    Molecular Therapy - Nucleic Acids (rok: 2022, tom: 29, strony: 64-74), Wydawca: Cell Press
    Status:
    Published
    DOI:
    10.1016/j.omtn.2022.05.035 - link to the publication
  7. Secondary Structure of Influenza A Virus Genomic Segment 8 RNA Folded in A Cellular Environment
    Authors:
    B. Szutkowska, K. Wieczorek, R. Kierzek, P. Zmora, J.M. Peterson, W.N. Moss, D.H. Mathews and E. Kierzek
    Academic press:
    International Journal of Molecular Sciences (rok: 2022, tom: 23, strony: 2452), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms23052452 - link to the publication
  8. Secondary Structure of Influenza A Virus Genomic Segment 8 RNA Folded in A Cellular Environment
    Authors:
    B. Szutkowska, K. Wieczorek, R. Kierzek, P. Zmora, J.M. Peterson, W.N. Moss, D.H. Mathews and E. Kierzek
    Academic press:
    International Journal of Molecular Sciences (rok: 2022, tom: 23, strony: 2452), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms23052452 - link to the publication

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