Projects funded by the NCN
Crystallographic analysis of RNA-ligand complexes. Towards rational design oflead compounds for development of therapies against neurodegenerative disorders
2022/45/B/NZ7/03543
Keywords:
RNA RNA ligands small synthetic molecules lead compounds interactions between RNA-ligand crystallographic analysis crystallographic structures of RNA-ligand complexes neurodegenerative disorders
Descriptors:
- NZ7_014:
- NZ1_004:
Panel:
NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology
Host institution :
Instytut Chemii Bioorganicznej PAN
woj. wielkopolskie
Principal investigator (from the host institution):
dr hab. Agnieszka Ludmiła Kiliszek
Number of co-investigators in the project: 4
Call: OPUS 23 - announced on 2022-03-28
Amount awarded: 2 045 208 PLN
Project start date (Y-m-d): 2023-01-20
Project end date (Y-m-d): 2027-01-19
Project duration:: 48 months (the same as in the proposal)
Project status: Pending project
Project description
Download the project description in a pdf file
Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Information in the final report
- Publication in academic press/journals (1)
- Antisense RNA C9orf72 hexanucleotide repeat associated with amyotrophic lateral sclerosis and frontotemporal dementia forms a triplex-like structure and binds small synthetic ligandAuthors:Leszek Błaszczyk, Marcin Ryczek, Bimolendu Das, Martyna Mateja-Pluta, Magdalena Bejger, Joanna Śliwiak, Kazuhiko Nakatani, Agnieszka KiliszekAcademic press:Nucleic Acids Research (rok: 2024, tom: 52, strony: 6707-6717), Wydawca: Oxford AcademicStatus:PublishedDOI:10.1093/nar/gkae376 - link to the publication