Projects funded by the NCN

Structural studies on inhibition mechanisms of enzymes belonging to USP family, which remove ubiquitin from eukaryotic p...

Call: SONATINA 1 , Panel: NZ1

Principal investigator: dr Marcin Jarosław Ziemniak

Uniwersytet Warszawski, Wydział Chemii

Investigating the biological role of 5' nucleotidases cN-IIIA and cN-IIIB in mRNA degradation and their terapeutic signi...

Call: SONATINA 1 , Panel: NZ1

Principal investigator: dr Dorota Maria Kubacka

Uniwersytet Warszawski, Wydział Fizyki

The study of the plant microRNA biogenesis molecular machinery using structural biology techniques.

Call: PRELUDIUM 12 , Panel: NZ1

Principal investigator: Przemysław Jacek Wieczorek

Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Biologii

DEVELOPMENT AND ANALYSIS OF SMALL COMPOUNDS AS CANDIDATE INHIBITORS OF PLANT GROUP A PROTEIN PHOSPHATASES TYPE 2C

Call: SONATA BIS 6 , Panel: NZ3

Principal investigator: dr hab. Agnieszka Wioletta Ludwików

Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Biologii

Biochemical and structural studies of retroviral reverse transcriptases evolution.

Call: OPUS 11 , Panel: NZ1

Principal investigator: dr hab. Elżbieta Nowak

Międzynarodowy Instytut Biologii Molekularnej i Komórkowej

Supramolecular Peptide Organic Frameworks (POFs)

Call: SYMFONIA 4 , Panel: ST5

Principal investigator: prof. Agnieszka Szumna

Instytut Chemii Organicznej Polska Akademia Nauk

Determination of structure and specificity of the RNA cap-modifying enzyme CMTr2.

Call: SONATA 10 , Panel: NZ1

Principal investigator: dr Veronika Martina Fluegel

Międzynarodowy Instytut Biologii Molekularnej i Komórkowej

The molecular mechanisms of pentapeptide repeat proteins action on DNA gyrase elucidated by structural biology methods

Call: POLONEZ 1 , Panel: NZ1

Principal investigator: dr Dmitry Ghilarov

Uniwersytet Jagielloński, Małopolskie Centrum Biotechnologii Uniwersytetu Jagiellońskiego

Structural insights into translational control of nanos mRNA by the Sex lethal repressive complex

Call: POLONEZ 1 , Panel: NZ1

Principal investigator: dr Monika Gaik

Uniwersytet Jagielloński, Małopolskie Centrum Biotechnologii Uniwersytetu Jagiellońskiego

Using X-ray crystallography for localization of the sites of binding of allosteric inhibitors and activators within the ...

Call: PRELUDIUM 9 , Panel: NZ1

Principal investigator: Julia Witkowska

Uniwersytet Gdański, Wydział Chemii

Non-catalytic domains of the RNA-guided DNA methyltransferase DRM2

Call: OPUS 9 , Panel: NZ1

Principal investigator: dr Humberto Fernandes

Instytut Biochemii i Biofizyki PAN

Structure analysis and identification of templates degraded by Regnase-1.

Call: OPUS 9 , Panel: NZ3

Principal investigator: prof. Jolanta Jura

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

Hyaluronic acid receptor stabilin-2: determination of the crystal structure and biochemical characterization of its bind...

Call: PRELUDIUM 9 , Panel: NZ1

Principal investigator: Aleksandra Anna Twarda-Cłapa

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

Fragment-based screening using NMR spectroscopy for the identification of chemical probes that interact with non-canonic...

Call: PRELUDIUM 9 , Panel: ST5

Principal investigator: Katarzyna Paulina Kubica

Uniwersytet Jagielloński, Wydział Chemii

2-oxoglutarate dependent oxygenases catalyzing atypical oxidative transformations - structural and mechanistic studies.

Call: OPUS 8 , Panel: NZ1

Principal investigator: prof. Tomasz Maciej Borowski

Instytut Katalizy i Fizykochemii Powierzchni im. Jerzego Habera PAN

Structure-function studies of RNA-binding proteins with FAST motifs and a RAP domain.

Call: SONATA 8 , Panel: NZ1

Principal investigator: dr Maria Wiktoria Górna

Uniwersytet Warszawski, Wydział Chemii

Structural biology of mixed lineage leukemia (MLL) proteins

Call: HARMONIA 6 , Panel: NZ5

Principal investigator: prof. Matthias Bochtler

Międzynarodowy Instytut Biologii Molekularnej i Komórkowej

2-Oxoglutarate dependent oxygenases in the biosynthesis of pharmacologically active alkaloids - structure, catalytic mec...

Call: SONATA BIS 4 , Panel: NZ1

Principal investigator: prof. Tomasz Maciej Borowski

Instytut Katalizy i Fizykochemii Powierzchni im. Jerzego Habera PAN

Biosynthesis of seleno-modified nucleosides in the anticodon loop of transfer ribonucleic acids. Evaluation of the enzym...

Call: OPUS 7 , Panel: ST5

Principal investigator: prof. Barbara Czesława Nawrot

Centrum Badań Molekularnych i Makromolekularnych PAN

New methodologies of solid state NMR spectroscopy in the structural studies and dynamics of selected proteins and peptid...

Call: OPUS 7 , Panel: ST4

Principal investigator: prof. Marek Józef Potrzebowski

Centrum Badań Molekularnych i Makromolekularnych PAN

Structural and thermodynamic studies of complexes avidin with luminescents and metallocenes biotin derivatives

Call: PRELUDIUM 6 , Panel: ST5

Principal investigator: Paweł Strzelczyk

Politechnika Łódzka, Wydział Biotechnologii i Nauk o Żywności

Exploiting the potential of synchrotron radiation for high resolution and weak signal in macromolecular crystallography

Call: HARMONIA 5 , Panel: NZ1

Principal investigator: prof. Mariusz Jaskólski

Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Chemii

The active center and beyond: towards new selective inhibitors of S-adenosyl-L-homocysteine hydrolase. Structural enzymo...

Call: OPUS 5 , Panel: NZ1

Principal investigator: dr Krzysztof Brzeziński

Uniwersytet w Białymstoku, Wydział Biologiczno-Chemiczny

Structural basis of biological properties of muscle fructose-1,6-bisphosphatase (FBPase) - a regulatory enzyme of glycon...

Call: OPUS 5 , Panel: NZ1

Principal investigator: prof. Andrzej Dżugaj

Uniwersytet Wrocławski, Wydział Nauk Biologicznych

The influence from aluminium on crystallography structure of zinc oxide (ZnO) - admituring with the aim to reduce the nu...

Call: PRELUDIUM 5 , Panel: ST3

Principal investigator: Ewelina Anna Wolska - Kornio

Instytut Fizyki PAN

Studies of the steric zipper motif in the sequence of human cystatin C (Ala52-Asp65)

Call: PRELUDIUM 4 , Panel: ST5

Principal investigator: dr Emilia Iłowska

Uniwersytet Gdański, Wydział Chemii

Kinases of emerging relevance in cancer - structural characterization.

Call: SONATA BIS 2 , Panel: NZ1

Principal investigator: dr Grzegorz Dubin

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

Structural study of the complexes of hydrolytic enzymes with heteroorganic substrates and substrate analogs

Call: OPUS 3 , Panel: ST4

Principal investigator: dr hab. Jarosław Błaszczyk

Centrum Badań Molekularnych i Makromolekularnych PAN

Determination of the crystal structure of the 10-23 deoxyribozyme and elucidation of the mechanism of action

Call: OPUS 3 , Panel: NZ1

Principal investigator: dr Rafał Mariusz Dolot

Centrum Badań Molekularnych i Makromolekularnych PAN

Structure and function of acireductone dioxygenases - experimental and computational studies.

Call: OPUS 2 , Panel: NZ1

Principal investigator: dr hab. Tomasz Maciej Borowski

Instytut Katalizy i Fizykochemii Powierzchni im. Jerzego Habera PAN

Designer nucleases from a structural and practical point of view

Call: MAESTRO 1 , Panel: NZ1

Principal investigator: prof. Matthias Bochtler

Instytut Biochemii i Biofizyki PAN

Crystallography of DNA repair enzymes as a tool to study substrate specifity and a mechanism of inhibition

Call: HARMONIA 1 , Panel: NZ1

Principal investigator: prof. Barbara Alicja Tudek

Instytut Biochemii i Biofizyki PAN

3D structure-based search for selective inhibitor of thymidylate synthase of nematodes, a potential drug in chemotherapy...

Call: OPUS 1 , Panel: NZ6

Principal investigator: prof. Wojciech Krzysztof Rode

Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

Structural and functional characterization of novel non-coding RNAs from Helicobacter pylori

Call: SONATA 1 , Panel: NZ1

Principal investigator: dr Grzegorz Maciej Chojnowski

Międzynarodowy Instytut Biologii Molekularnej i Komórkowej

RNA hairpin structures in biology and pathogenesis. Crystallographic analysis.

Call: OPUS 1 , Panel: NZ1

Principal investigator: prof. Wojciech Robert Rypniewski

Instytut Chemii Bioorganicznej PAN