Projects funded by the NCN


Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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RNA hairpin structures in biology and pathogenesis. Crystallographic analysis.

2011/01/B/NZ1/04429

Keywords:

RNA hairpin structure crystallography

Descriptors:

  • NZ1_4: Structural biology
  • NZ1_3: Biophysics
  • NZ1_2: Biochemistry

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Instytut Chemii Bioorganicznej PAN

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Wojciech Rypniewski 

Number of co-investigators in the project: 7

Call: OPUS 1 - announced on 2011-03-15

Amount awarded: 492 700 PLN

Project start date (Y-m-d): 2011-12-06

Project end date (Y-m-d): 2015-06-05

Project duration:: 42 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Kolumna do oczyszczania oligomerów po syntezie (15 000 PLN)
  2. Sprzęt do elektroforezy RNA: zasilacz na 3000 V oraz aparat do elektroforezy pionowej (16 000 PLN)
  3. drukarka.
  4. Koncentrator próżniowy z dwoma rotorami, wymrażaczem i pompą membranową (odporną chemicznie) (70 000 PLN)

Information in the final report

  • Publication in academic press/journals (6)
  1. Struktura a patogeneza powtórzeń CNG
    Authors:
    Agnieszka Kiliszek, Wojciech Rypniewski
    Academic press:
    Wiadomości Chemiczne (rok: 2014, tom: 68, strony: 563-585), Wydawca: Polskie Towarzystwo Chemiczne
    Status:
    Published
  2. Stabilization of RNA hairpins using non-nucleotide linkers and circularization
    Authors:
    Agnieszka Kiliszek, Leszek Błaszczyk, Ryszard Kierzek, Wojciech Rypniewski
    Academic press:
    Nucleic Acids Research (rok: 2017, ), Wydawca: Oxford University Press
    Status:
    Accepted for publication
    DOI:
    10.1093/nar/gkx122 - link to the publication
  3. Structural studies of CNG repeats
    Authors:
    A. Kiliszek & W. Rypniewski
    Academic press:
    Nucleic Acids Research (rok: 2014, tom: 42, strony: 8189-8199), Wydawca: Oxford University Press
    Status:
    Published
    DOI:
    10.1093/nar/gku536 - link to the publication
  4. Watson-Crick-like pairs in CCUG repeats. Evidence for tautomeric shifts or protonation.
    Authors:
    Wojciech Rypniewski, Katarzyna Banaszak, Tadeusz Kulinski, Agnieszka Kiliszek
    Academic press:
    RNA (rok: 2016, tom: 22, strony: 22-31), Wydawca: Cold Spring Harbor Laboratory Press
    Status:
    Published
    DOI:
    10.1261/rna.052399.115 - link to the publication
  5. Structures of RNA repeats associated with neurological diseases.
    Authors:
    Leszek Blaszczyk, Wojciech Rypniewski, Agnieszka Kiliszek
    Academic press:
    WIREs RNA (rok: 2017, ), Wydawca: Wiley
    Status:
    Accepted for publication
    DOI:
    10.1002/wrna.1412 - link to the publication
  6. The first crystal structures of RNA–PNA duplexes and a PNA-PNA duplex containing mismatches––toward anti-sense therapy against TREDs
    Authors:
    Agnieszka Kiliszek, Katarzyna Banaszak, Zbigniew Dauter, Wojciech Rypniewski
    Academic press:
    Nucleic Acids Research (rok: 2016, tom: 44, strony: 1937-1943), Wydawca: Oxford University Press
    Status:
    Published
    DOI:
    10.1093/nar/gkv1513 - link to the publication