Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Using X-ray crystallography for localization of the sites of binding of allosteric inhibitors and activators within the proteasome structure

2015/17/N/NZ1/01772

Keywords:

proteasome crystal structure allosteric modulators

Descriptors:

  • NZ1_4: Structural biology
  • ST5_16:

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Uniwersytet Gdański, Wydział Chemii

woj. pomorskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Julia Witkowska 

Number of co-investigators in the project: 2

Call: PRELUDIUM 9 - announced on 2015-03-16

Amount awarded: 49 500 PLN

Project start date (Y-m-d): 2016-03-03

Project end date (Y-m-d): 2017-09-02

Project duration:: 18 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Dewar transportowy (6 000 PLN)
  2. komputer (4 500 PLN)

Information in the final report

  • Publication in academic press/journals (2)
  • Articles in post-conference publications (2)
  1. Crystal structure of a low molecular weight activator Blm-pep with yeast 20S proteasome – insights into the enzyme activation mechanism
    Authors:
    Julia Witkowska, Małgorzata Giżyńska, Przemysław Grudnik, Przemysław Golik, Przemysław Karpowicz, Artur Giełdoń, Grzegorz Dubin, Elżbieta Jankowska
    Academic press:
    Scientific Reports (rok: 2017, tom: 7, strony: 6177), Wydawca: Nature publishing group
    Status:
    Published
    DOI:
    10.1038/s41598-017-05997-4 - link to the publication
  2. Proline- and Arginine-Rich Peptides as Flexible Allosteric Modulators of Human Proteasome Activity
    Authors:
    Małgorzata Giżyńska, Julia Witkowska, Przemysław Karpowicz, Rafał Rostankowski, Estrella S. Chocron, Andrew M. Pickering, Pawel Osmulski, Maria Gaczynska, Elżbieta Jankowska
    Academic press:
    Journal of Medicinal Chemistry (rok: 2018, tom: 62, strony: 359-370), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.jmedchem.8b01025 - link to the publication
  1. Exploring relationship between PR peptides conformation and their activating and inhibitory effect on the 20S proteasome
    Authors:
    Witkowska Julia, Giżyńska Małgorzata, Karpowicz Przemysław, Gaczyńska Maria , Osmulski Paweł, Jankowska Elżbieta
    Conference:
    24 Polish Peptide Symposium (rok: 2017, ), Wydawca: Department of Biomedical Chemistry Faculty of Chemistry, University of Gdańsk
    Data:
    konferencja 3-7.09.2017
    Status:
    Published
  2. Correlation between PR peptides conformation and their activating and inhibitory capacity towards the 20S proteasome
    Authors:
    Julia Witkowska, Malgorzata Gizynska, Przemyslaw Karpowicz, Magdalena Kropidlowska, Elzbieta Jankowska
    Conference:
    VII EFMC International Symposium on Advances in Synthetic and Medicinal Chemistry (rok: 2017, ), Wydawca: European Federation for Medicinal Chemistry (EFMC)
    Data:
    konferencja 27-31.08. 2017
    Status:
    Published

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