Projects funded by the NCN

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48 projects found matching your search criteria :

  1. Dual-Target Compounds Modulating EAAT2 and Kv7.2/3 Channels: A Rational Strategy Toward Novel Antiseizure and Antinocice...

    Call: OPUS 29 , Panel: NZ7

    Principal investigator: dr Michał Andrzej Abram

    Uniwersytet Jagielloński

  2. Design and Pharmacological Evaluation of Marine Alkaloid-Inspired 5-HT2A Receptor Ligands

    Call: PRELUDIUM 24 , Panel: NZ1

    Principal investigator: Szymon Kazimierz Kordylewski

    Instytut Farmakologii PAN

  3. NMR Spectroscopy as Molecular Language: A Deep Learning Approach to Bioactivity Prediction

    Call: PRELUDIUM 24 , Panel: NZ7

    Principal investigator: Arkadiusz Bogumił Leniak

    Instytut Farmakologii PAN

  4. Stealth" asparaginases as improved protein drugs for the treatment of childhood acute lymphoblastic leukemia (ALL)

    Call: OPUS 27 , Panel: NZ1

    Principal investigator: prof. Matthias Bochtler

    Międzynarodowy Instytut Biologii Molekularnej i Komórkowej

  5. Development and characterization of novel multitargeted organometallic tubulin polymerization inhibitors for enhancing t...

    Call: OPUS 27 , Panel: NZ7

    Principal investigator: dr hab. Damian Nestor Plażuk

    Uniwersytet Łódzki

  6. Taming aggregation with AmyloGraph 2.0: a database and prediction models of amyloid self-assembly modulators

    Call: SONATA 19 , Panel: NZ7

    Principal investigator: dr Michał Jan Burdukiewicz

    Uniwersytet Medyczny w Białymstoku

  7. Design and characterisation of sealing materials of prosthetic obturator being additionally a cytostatic drug reservoir....

    Call: OPUS 26 , Panel: ST8

    Principal investigator: prof. Anna Trusek

    Politechnika Wrocławska

  8. Design and Development of Serine Hydroxymethyltransferase-2 (SHMT2) Inhibitors Blocking Tumor Growth

    Call: SONATA BIS 13 , Panel: NZ7

    Principal investigator: dr hab. Miłosz Ruszkowski

    Instytut Chemii Bioorganicznej PAN

  9. Search for novel IKK-β inhibitors in the context of diseases with neuroinflammatory origin – structure-based drug design...

    Call: PRELUDIUM 22 , Panel: NZ7

    Principal investigator: Emilia Aleksandra Sługocka

    Uniwersytet Jagielloński, Collegium Medicum

  10. "I like to move it, move it" – molecular dynamics-driven optimization of ligand residence time as an opportunity to impr...

    Call: OPUS 25 , Panel: NZ7

    Principal investigator: dr hab. Sabina Marta Podlewska

    Instytut Farmakologii PAN

  11. Bis(benzosiloxaboroles) as a new class of potential antibiotics - a perspective solution to growing problem of antimicro...

    Call: PRELUDIUM 22 , Panel: ST5

    Principal investigator: Krzysztof Nowicki

    Politechnika Warszawska, Wydział Chemiczny

  12. Designing Active Inhibitors of SARS-CoV-2 Methyltransferases

    Call: PRELUDIUM 22 , Panel: NZ7

    Principal investigator: Alex Jun Matsuda

    Uniwersytet Jagielloński, Małopolskie Centrum Biotechnologii Uniwersytetu Jagiellońskiego

  13. Decrypting the "sulfation code" of glycosaminoglycans for understanding their function in the extracellular matrix

    Call: OPUS 25 , Panel: ST4

    Principal investigator: dr hab. Sergey Samsonov

    Uniwersytet Gdański, Wydział Chemii

  14. Design, Synthesis and Characterization of Functionalized 1,2,4-Trioxanes/Trioxepanes for Antimalarial and Anticancer Use

    Call: SONATINA 7 , Panel: NZ7

    Principal investigator: dr Mohit Kumar Tiwari

    Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu

  15. Targeted inhibition of hypusination pathway

    Call: OPUS 24 , Panel: NZ7

    Principal investigator: dr Przemysław Marek Grudnik

    Uniwersytet Jagielloński, Małopolskie Centrum Biotechnologii Uniwersytetu Jagiellońskiego

  16. Three-phase drug carriers - design towards a prolonged release, development of a transport model and its verification. C...

    Call: PRELUDIUM BIS 4 , Panel: ST8

    Principal investigator: prof. Anna Trusek

    Politechnika Wrocławska

  17. Computational deciphering of pro-ferroptotic cell death protein machinery as a fundamental step in the search for therap...

    Call: SONATA BIS 12 , Panel: ST4

    Principal investigator: dr hab. Karolina Anna Mikulska-Rumińska

    Uniwersytet Mikołaja Kopernika, Wydział Fizyki, Astronomii i Informatyki Stosowanej

  18. Novel broad-spectrum central nervous system active substances: optimization of their multi-target profile

    Call: OPUS 22 , Panel: NZ7

    Principal investigator: dr hab. Agnieszka Anna Kaczor

    Uniwersytet Medyczny w Lublinie, Wydział Farmaceutyczny

  19. Structure-guided design of histone demethylase inhibitors for cancer therapy.

    Call: SONATA 17 , Panel: NZ7

    Principal investigator: dr Piotr Henryk Małecki

    Instytut Chemii Bioorganicznej PAN

  20. Inhibiting the Mitochondrial Intermembrane Space Assembly pathway as a newapproach to prevent metabolic reprogramming of...

    Call: OPUS 22 , Panel: NZ5

    Principal investigator: dr hab. Carlo Vascotto

    Międzynarodowy Instytut Mechanizmów i Maszyn Molekularnych Polskiej Akademii Nauk

  21. Search for Inhibitors of Human δ1-Pyrroline-5-Carboxylate Reductase 1 (PYCR1) as Lead Molecules for the Development of N...

    Call: OPUS 22 , Panel: NZ7

    Principal investigator: dr hab. Miłosz Ruszkowski

    Instytut Chemii Bioorganicznej PAN

  22. Towards the integrated molecular modelling – machine learning (MM-ML)" computational method for supporting the design of...

    Call: SHENG 2 , Panel: ST5

    Principal investigator: prof. Tomasz Puzyn

    Uniwersytet Gdański, Wydział Chemii

  23. Self-learning systems in the design of compounds modulating GPCR receptors activation.

    Call: OPUS 20 , Panel: NZ2

    Principal investigator: dr hab. Dorota Latek

    Uniwersytet Warszawski, Wydział Chemii

  24. Development of tools for the rational design of peptide therapeutics

    Call: OPUS 20 , Panel: NZ2

    Principal investigator: dr hab. Sebastian Kmiecik

    Uniwersytet Warszawski, Centrum Nauk Biologiczno-Chemicznych

  25. The new methodology for better understanding of ligand-RNA interactions.

    Call: OPUS 20 , Panel: NZ2

    Principal investigator: dr Filip Artur Stefaniak

    Międzynarodowy Instytut Biologii Molekularnej i Komórkowej

  26. Combination of Molecular Simulation and Deep Learning for De Novo Drug Design

    Call: PRELUDIUM 19 , Panel: ST6

    Principal investigator: dr Tomasz Jakub Danel

    Uniwersytet Jagielloński, Wydział Matematyki i Informatyki

  27. Homo- and heterometallic phosphine ruthenium and iridium complexes - design, synthesis, bioactivity and magnetic-nanofor...

    Call: PRELUDIUM 19 , Panel: ST4

    Principal investigator: Sandra Amanda Kozieł

    Uniwersytet Wrocławski, Wydział Chemii

  28. Novel L-asparaginases as potential therapeutic agents and antimicrobial targets: structural and functional studies of en...

    Call: OPUS 19 , Panel: NZ1

    Principal investigator: prof. Mariusz Jaskólski

    Instytut Chemii Bioorganicznej PAN

  29. Novel approach in the search for asthma and COPD therapies - computer aided design of multi-target-directed ligands bloc...

    Call: PRELUDIUM 19 , Panel: NZ7

    Principal investigator: Alicja Aleksandra Gawalska

    Uniwersytet Jagielloński, Collegium Medicum

  30. Fluorine substitution – a new algorithm for increasing biological activity

    Call: PRELUDIUM 18 , Panel: NZ7

    Principal investigator: Wojciech Pietruś

    Instytut Farmakologii PAN

  31. Molecular mechanisms, signal transduction and inhibition of PEBP1-15LOX protein complex triggering the ferroptotic cell ...

    Call: SONATA 15 , Panel: ST4

    Principal investigator: dr hab. Karolina Anna Mikulska-Rumińska

    Uniwersytet Mikołaja Kopernika, Wydział Fizyki, Astronomii i Informatyki Stosowanej

  32. Rational design and evaluation of functionally biased opioid agonists

    Call: OPUS 16 , Panel: NZ7

    Principal investigator: prof. Ryszard Przewłocki

    Instytut Farmakologii PAN

  33. Development of a comprehensive set of computational tools for the search of new ligands of particular receptor - case st...

    Call: OPUS 16 , Panel: NZ2

    Principal investigator: dr hab. Sabina Marta Podlewska

    Instytut Farmakologii PAN

  34. Molecular picture of the mechanochemical coupling in ATP synthase as a conceptual framework for the development of novel...

    Call: SONATA BIS 7 , Panel: NZ2

    Principal investigator: dr hab. Jacek Czub

    Politechnika Gdańska, Wydział Chemiczny

  35. Modeling of quantitative structure-metabolic stability relationships as a tool to improve design of potential novel anti...

    Call: OPUS 12 , Panel: NZ7

    Principal investigator: prof. Tomasz Bączek

    Gdański Uniwersytet Medyczny, Wydział Farmaceutyczny

  36. Novel multi-target directed ligands combining cholinesterase inhibition and 5-HT6 antagonism - design, synthesis and pha...

    Call: SONATA 12 , Panel: NZ7

    Principal investigator: dr hab. Anna Karolina Więckowska

    Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny

  37. Structural studies of signaling receptors HVEM/CD160 as potential targets for immunoterapy against melanoma

    Call: SONATA 11 , Panel: NZ1

    Principal investigator: dr Marta Orlikowska

    Uniwersytet Gdański, Wydział Chemii

  38. Design, bio and diversity oriented synthesis of fused pyridin-4(1H)-ones, 4H-pyrane-4-ones and 4H-thiopyran-4-ones as po...

    Call: POLONEZ 2 , Panel: ST5

    Principal investigator: dr Satenik Mkrtchyan

    Centrum Badań Molekularnych i Makromolekularnych PAN

  39. Development of protocol for in silico design of compounds inhibit Ebola virus infection

    Call: PRELUDIUM 11 , Panel: NZ2

    Principal investigator: Dawid Zdzisław Warszycki

    Instytut Farmakologii PAN

  40. Validation of aspherical pseudoatom databank in order to estimate electrostatic interaction energy.

    Call: PRELUDIUM 10 , Panel: ST4

    Principal investigator: Monika Anna Wanat

    Uniwersytet Warszawski, Wydział Chemii

  41. Design, synthesis and analysis of electrospun materials based on biodegradable polymers as potential drug delivery syste...

    Call: PRELUDIUM 9 , Panel: ST8

    Principal investigator: Marek Wojciech Rychter

    Uniwersytet im. Adama Mickiewicza w Poznaniu, Centrum Nanobiomedyczne

  42. Study of iron catalysis for the activation of carbon-hydrogen bonds: design of new reactions and their application in me...

    Call: SONATA 8 , Panel: ST5

    Principal investigator: dr Michał Szostak

    Uniwersytet Opolski, Wydział Chemii

  43. Bioactive organoselenium compounds in self-organizing systems: design, synthesis and biological evaluation

    Call: SONATA 5 , Panel: ST5

    Principal investigator: dr Magdalena Piętka-Ottlik

    Politechnika Wrocławska, Wydział Chemiczny

  44. Deeper insight into styrylquinolines' activity spectrum

    Call: OPUS 5 , Panel: NZ7

    Principal investigator: dr hab. Robert Musioł

    UNIWERSYTET ŚLĄSKI, Wydział Matematyki, Fizyki i Chemii

  45. Computer aided design and prediction of properties of drug delivery systems based on carbon nanotubes architecture

    Call: SONATA BIS 2 , Panel: ST4

    Principal investigator: dr hab. Tomasz Pańczyk

    Instytut Katalizy i Fizykochemii Powierzchni im. Jerzego Habera PAN

  46. Drug Design: Chirality Measures as QSAR descriptors.

    Call: PRELUDIUM 3 , Panel: NZ7

    Principal investigator: Piotr Jakub Lipiński

    Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

  47. The influence of molecular fingerprint bit density on chemical pattern recognition effectiveness

    Call: PRELUDIUM 2 , Panel: NZ2

    Principal investigator: Rafał Jerzy Kurczab

    Instytut Farmakologii PAN

  48. Development of a method for the structure prediction of GPCRs complexes with agonists and antagonists, including the lig...

    Call: SONATA 1 , Panel: NZ2

    Principal investigator: dr Michał Koliński

    Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

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