Projects funded by the NCN
Structure-guided design of histone demethylase inhibitors for cancer therapy.
2021/43/D/NZ7/02879
Keywords:
cancer therapy epigenetics histone demethylases KDM4 fragment based drug creation crystallographic fragment screening hit optimisation inhibitor synthesis
Descriptors:
- NZ7_014:
- NZ1_004:
Panel:
NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology
Host institution :
Instytut Chemii Bioorganicznej PAN
woj. wielkopolskie
Principal investigator (from the host institution):
Number of co-investigators in the project: 4
Call: SONATA 17 - announced on 2021-09-15
Amount awarded: 1 641 876 PLN
Project start date (Y-m-d): 2022-12-15
Project end date (Y-m-d): 2025-12-14
Project duration:: 36 months (the same as in the proposal)
Project status: Project completed
Project description
Download the project description in a pdf file
Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Information in the final report
- Publication in academic press/journals (1)
- Structure-based mapping of the histone-binding pocket of KDM4D using functionalized tetrazole and pyridine core compoundsAuthors:Piotr H. Małecki, Georg M. Fassauer, Nicole Rüger, Lukas Schulig, Andreas Link, Oxana Krylova, Udo Heinemann, Manfred S. WeissAcademic press:European Journal of Medicinal Chemistry (rok: 2024, tom: 276, strony: 46036), Wydawca: ElsevierStatus:PublishedDOI:10.1016/j.ejmech.2024.116642 - link to the publication