Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Modeling of quantitative structure-metabolic stability relationships as a tool to improve design of potential novel antidepressant and anxiolytic drug candidates.

2016/23/B/NZ7/02916

Keywords:

arylpiperazines metabolic stability molecular modeling

Descriptors:

  • NZ1_2: Biochemistry
  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Gdański Uniwersytet Medyczny, Wydział Farmaceutyczny

woj. pomorskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Tomasz Bączek 

Number of co-investigators in the project: 6

Call: OPUS 12 - announced on 2016-09-15

Amount awarded: 872 560 PLN

Project start date (Y-m-d): 2017-09-06

Project end date (Y-m-d): 2022-09-05

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Project description

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Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (6)
  1. Use of biomimetic chromatography and in vitro assay to develop predictive GA-MLR model for use in drug-property prediction among anti-depressant drug candidates
    Authors:
    Szymon Ulenberg, Krzesimir Ciura, Paweł Georgiev, Monika Pastewska, Grzegorz Ślifirski, Marek Król, Franciszek Herold, Tomasz Bączek
    Academic press:
    Microchemical Journal (rok: 2022, tom: 175, strony: 45300), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.microc.2022.107183 - link to the publication
  2. Understanding performance of 3D-printed sorbent in study of metabolic stability
    Authors:
    Szymon Ulenberg, Paweł Georgiev, Mariusz Belka, Grzegorz Ślifirski, Martyna Wróbel, Andrzej Chodkowski, Marek Król, Franciszek Herold, Tomasz Bączek
    Academic press:
    Journal of Chromatography A (rok: 2020, tom: 1629, strony: 45300), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.chroma.2020.461501 - link to the publication
  3. Metabolic stability studies of lead compounds supported by separation techniques and chemometrics analysis
    Authors:
    Ulenberg Szymon, Bączek Tomasz
    Academic press:
    Journal of Separation Science (rok: 2020, tom: 44, strony: 373-386), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/jssc.202000831 - link to the publication
  4. Synthesis and biological evaluation of new multi-target 3-(1H-indol-3-yl)pyrrolidine-2,5-dione derivatives with potential antidepressant effect
    Authors:
    Martyna Z. Wróbel, Andrzej Chodkowski, Franciszek Herold, Monika Marciniak, Maciej Dawidowski, Agata Siwek, Gabriela Starowicz, Katarzyna Stachowicz, Bernadeta Szewczyk, Gabriel Nowak, Mariusz Belka, Tomasz Bączek, Grzegorz Satała, Andrzej J. Bojarski, Jadwiga Turło
    Academic press:
    European Journal of Medicinal Chemistry (rok: 2019, tom: 183, strony: -), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ejmech.2019.111736 - link to the publication
  5. Synthesis of new 5,6,7,8-tetrahydropyrido[1,2-c]pyrimidine derivatives with rigidized tryptamine moiety as potential SSRI and 5-HT1A receptor ligands
    Authors:
    Grzegorz Ślifirski, Marek Król, Jerzy Kleps, Piotr Podsadni, Mariusz Belka, Tomasz Bączek, Agata Siwek, Katarzyna Stachowicz, Bernadeta Szewczyk, Gabriel Nowak, Andrzej Bojarski, Anna E. Kozioł, Jadwiga Turło, Franciszek Herold
    Academic press:
    European Journal of Medicinal Chemistry (rok: 2019, tom: 180, strony: 383-397), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ejmech.2019.07.027 - link to the publication
  6. The influence of phase II enzymes on in vitro half-life of pirydo[1,2-c]pirymidine derivatives as structural analogues of arylpiperazine
    Authors:
    Szymon Ulenberg, Mariusz Belka, Paweł Georgiev, Grzegorz Ślifirski, Marek Król, Franciszek Herold, Tomasz Bączek
    Academic press:
    Microchemical Journal (rok: 2020, tom: 159, strony: -), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.microc.2020.105550 - link to the publication

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