Projects funded by the NCN

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Information of the project and the call

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Homo- and heterometallic phosphine ruthenium and iridium complexes - design, synthesis, bioactivity and magnetic-nanoformulation as a potential platform for dual-targeted drug delivery.

2020/37/N/ST4/02698

Keywords:

selective transport heterometallic ruthenium(II)/copper(II) and iridium(III)/copper(II) complexes phosphines cytotoxicity bimolecules interations magnetic nanoparticle nanomedicine

Descriptors:

  • ST4_20: Inorganic chemistry
  • ST5_10: Functional materials/nanomaterials, nanoparticles
  • ST4_9: Biological chemistry

Panel:

ST4 - Chemistry: physical chemistry/chemical physics, theoretical chemistry, analytical chemistry, inorganic chemistry, organic chemistry, method development

Host institution :

Uniwersytet Wrocławski, Wydział Chemii

woj.

Other projects carried out by the institution 

Principal investigator (from the host institution):

Sandra Amanda Kozieł 

Number of co-investigators in the project: 3

Call: PRELUDIUM 19 - announced on 2020-03-16

Amount awarded: 195 600 PLN

Project start date (Y-m-d): 2021-01-14

Project end date (Y-m-d): 2024-01-13

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Project description

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Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (15)
  1. Interaction between DNA, Albumin and Apo-Transferrin and Iridium(III) Complexes with Phosphines Derived from Fluoroquinolones as a Potent Anticancer Drug
    Authors:
    Sandra Amanda Kozieł, Monika Katarzyna Lesiów, Daria Wojtala, Edyta Dyguda-Kazimierowicz, Dariusz Bieńko, Urszula Katarzyna Komarnicka
    Academic press:
    Pharmaceuticals (rok: 2021, tom: 14, strony: 685/1-685/25), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ph14070685 - link to the publication
  2. Synthesis, physicochemical characterization and antiproliferative activity of phosphino Ru(II) and Ir(III) complexes
    Authors:
    Komarnicka Urszula K., Kozieł Sandra, Skórska-Stania Agnieszka, Kyzioł Agnieszka, Tisato Francesco
    Academic press:
    Dalton Transaction (rok: 2022, tom: 51, strony: 8605-8617), Wydawca: The Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/d2dt01055k - link to the publication
  3. Two out of Three Musketeers Fight against Cancer: Synthesis, Physicochemical, and Biological Properties of Phosphino CuI, RuII, IrIII Complexes
    Authors:
    Urszula K. Komarnicka, Alessandro Niorettini, Sandra Kozieł, Barbara Pucelik, Agata Barzowska, Daria Wojtala, Aleksandra Ziółkowska, Monika Lesiów, Agnieszka Kyzioł, Stefano Caramori, Marina Porchia, Alina Bieńko
    Academic press:
    Pharmaceuticals (rok: 2022, tom: 15, strony: 169/1-169/22), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ph15020169 - link to the publication
  4. Insights into the binding of half-sandwich phosphino Ir(III) and Ru(II) complexes to deoxyribonucleic acid, albumin and apo-transferrin: Experimental and theoretical investigation
    Authors:
    Kozieł Sandra, Wojtala Daria, Szmitka Magdalena, Kędzierski Paweł, Bieńko Dariusz, Komarnicka Urszula K.
    Academic press:
    Spectrochimica Acta Part A-Molecular and Biomolecular Spectroscopy (rok: 2023, tom: 304, strony: 123289/1-123289/14), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.saa.2023.123289 - link to the publication
  5. Two out of Three Musketeers Fight against Cancer: Synthesis, Physicochemical, and Biological Properties of Phosphino CuI, RuII, IrIII Complexes
    Authors:
    Urszula K. Komarnicka, Alessandro Niorettini, Sandra Kozieł, Barbara Pucelik, Agata Barzowska, Daria Wojtala, Aleksandra Ziółkowska, Monika Lesiów, Agnieszka Kyzioł, Stefano Caramori, Marina Porchia, Alina Bieńko
    Academic press:
    Pharmaceuticals (rok: 2022, tom: 15, strony: 169/1-169/22), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ph15020169 - link to the publication
  6. Cellular Mechanistic Considerations on Cytotoxic Mode of Action of Phosphino Ru(II) and Ir(III) Complexes
    Authors:
    Wojtala Daria B., Komarnicka Urszula K., Kyzioł Agnieszka, Kozieł Sandra, Szmitka Magdalena, Słowikowski Mateusz, Stochel Grażyna
    Academic press:
    European Journal of Inorganic Chemistry (rok: 2023, tom: 26, strony: e202300515/1-e202300515/10), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/ejic.202300515 - link to the publication
  7. Interaction between DNA, Albumin and Apo-Transferrin and Iridium(III) Complexes with Phosphines Derived from Fluoroquinolones as a Potent Anticancer Drug
    Authors:
    Sandra Amanda Kozieł, Monika Katarzyna Lesiów, Daria Wojtala, Edyta Dyguda-Kazimierowicz, Dariusz Bieńko, Urszula Katarzyna Komarnicka
    Academic press:
    Pharmaceuticals (rok: 2021, tom: 14, strony: 685/1-685/25), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ph14070685 - link to the publication
  8. Antibactericidal Ir(III) and Ru(II) Complexes with Phosphine‐Alkaloid Conjugate and Their Interactions with Biomolecules: A Case of N‐Methylphenethylamine
    Authors:
    Wojtala Daria, Kozieł Sandra, Witwicki Maciej, Niorettini Alessandro, Guz-Regner Katarzyna, Bugla-Płoskońska Gabriela, Caramori Stefano, Komarnicka Urszula K.
    Academic press:
    Chemistry-A European Journal (rok: 2023, tom: 29, strony: e202301603/1-e202301603/10), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/chem.202301603 - link to the publication
  9. Two out of Three Musketeers Fight against Cancer: Synthesis, Physicochemical, and Biological Properties of Phosphino CuI, RuII, IrIII Complexes
    Authors:
    Urszula K. Komarnicka, Alessandro Niorettini, Sandra Kozieł, Barbara Pucelik, Agata Barzowska, Daria Wojtala, Aleksandra Ziółkowska, Monika Lesiów, Agnieszka Kyzioł, Stefano Caramori, Marina Porchia, Alina Bieńko
    Academic press:
    Pharmaceuticals (rok: 2022, tom: 15, strony: 169/1-169/22), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ph15020169 - link to the publication
  10. Synthesis, physicochemical characterization and antiproliferative activity of phosphino Ru(II) and Ir(III) complexes
    Authors:
    Komarnicka Urszula K., Kozieł Sandra, Skórska-Stania Agnieszka, Kyzioł Agnieszka, Tisato Francesco
    Academic press:
    Dalton Transaction (rok: 2022, tom: 51, strony: 8605-8617), Wydawca: The Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/d2dt01055k - link to the publication
  11. Liposomal Binuclear Ir(III)–Cu(II) Coordination Compounds with Phosphino-Fluoroquinolone Conjugates for Human Prostate Carcinoma Treatment
    Authors:
    Komarnicka Urszula K., Kozieł Sandra, Pucelik Barbara, Barzowska Agata, Siczek Miłosz, Malik Magdalena, Wojtala Daria, Niorettini Alessandro, Kyzioł Agnieszka, Sebastian Victor, Kopel Pavel, Caramori Stefano, Bieńko Alina
    Academic press:
    Inorganic Chemistry (rok: 2022, tom: 61, strony: 19261–19273), Wydawca: ACS Publications
    Status:
    Published
    DOI:
    10.1021/acs.inorgchem.2c03015 - link to the publication
  12. Copper(ii) complexes with 2-ethylpyridine and related hydroxyl pyridine derivatives: structural, spectroscopic, magnetic and anticancer in vitro studies
    Authors:
    Malik Magdalena, Świtlicka Anna, Bieńko Alina, Komarnicka Urszula K., Bieńko Dariusz C., Kozieł Sandra, Kyzioł Agnieszka, Mazur Tomasz, Machura Barbara
    Academic press:
    RSC Advances (rok: 2022, tom: 12, strony: 27648-27665), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/D2RA05133H - link to the publication
  13. Liposomal Binuclear Ir(III)–Cu(II) Coordination Compounds with Phosphino-Fluoroquinolone Conjugates for Human Prostate Carcinoma Treatment
    Authors:
    Komarnicka Urszula K., Kozieł Sandra, Pucelik Barbara, Barzowska Agata, Siczek Miłosz, Malik Magdalena, Wojtala Daria, Niorettini Alessandro, Kyzioł Agnieszka, Sebastian Victor, Kopel Pavel, Caramori Stefano, Bieńko Alina
    Academic press:
    Inorganic Chemistry (rok: 2022, tom: 61, strony: 19261–19273), Wydawca: ACS Publications
    Status:
    Published
    DOI:
    10.1021/acs.inorgchem.2c03015 - link to the publication
  14. Copper(ii) complexes with 2-ethylpyridine and related hydroxyl pyridine derivatives: structural, spectroscopic, magnetic and anticancer in vitro studies
    Authors:
    Malik Magdalena, Świtlicka Anna, Bieńko Alina, Komarnicka Urszula K., Bieńko Dariusz C., Kozieł Sandra, Kyzioł Agnieszka, Mazur Tomasz, Machura Barbara
    Academic press:
    RSC Advances (rok: 2022, tom: 12, strony: 27648-27665), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/D2RA05133H - link to the publication
  15. Interaction between DNA, Albumin and Apo-Transferrin and Iridium(III) Complexes with Phosphines Derived from Fluoroquinolones as a Potent Anticancer Drug
    Authors:
    Sandra Amanda Kozieł, Monika Katarzyna Lesiów, Daria Wojtala, Edyta Dyguda-Kazimierowicz, Dariusz Bieńko, Urszula Katarzyna Komarnicka
    Academic press:
    Pharmaceuticals (rok: 2021, tom: 14, strony: 685/1-685/25), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ph14070685 - link to the publication

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