Projects funded by the NCN

Antibacterial molecules based on bacteriophage proteins and constant antibody fragments with therapeutic potential for t...

Call: SONATA 20 , Panel: NZ7

Principal investigator: dr Karolina Aleksandra Filik-Matyjaszczyk

Instytut Immunologii i Terapii Doświadczalnej im. Ludwika Hirszfelda Polskiej Akademii Nauk

Analysis of pharmacokinetic, pharmacodynamic and molecular determinants of intolerance and resistance to the Janus kinas...

Call: OPUS 27 , Panel: NZ7

Principal investigator: dr hab. Marta Katarzyna Karaźniewicz-Łada

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu

Small molecule modulators of the tumor necrosis factor alpha signaling pathway for the inhibition of inflammatory proces...

Call: OPUS 27 , Panel: NZ7

Principal investigator: prof. Tadeusz Holak

Uniwersytet Gdański

Innovative Small Molecule Inhibitors Targeting LAG-3 and MHCII Complex for Tumour Immunotherapy

Call: OPUS 27 , Panel: NZ7

Principal investigator: dr Jacek Plewka

Uniwersytet Jagielloński

A Compound Screening Platform for the Discovery of Histone- and Nucleosome-Targeting Agents

Call: OPUS 27 , Panel: NZ7

Principal investigator: prof. Curtis Davey

Uniwersytet Jagielloński

Developmental neurotoxicity of nanoplastic. Functional, structural and molecular analysis of the neurovascular unit in t...

Call: PRELUDIUM 23 , Panel: NZ7

Principal investigator: Kamil Dawid Adamiak

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

The impact of physical activity on the gut-brain axis molecular adaptation to chronic stress

Call: PRELUDIUM 23 , Panel: NZ7

Principal investigator: Julia Wiktoria Morys

Akademia Wychowania Fizycznego im. Jerzego Kukuczki w Katowicach

Cellular and molecular basis of antifungal activity of metallacarboranes against Candida albicans

Call: OPUS 27 , Panel: NZ7

Principal investigator: dr hab. Konrad Kubiński

Katolicki Uniwersytet Lubelski Jana Pawła II

Molecular mechanisms underlying the liver injury induced by ulipristal acetate treatment

Call: PRELUDIUM 23 , Panel: NZ7

Principal investigator: Aleksandra Natalia Łupińska

Instytut Rozrodu Zwierząt i Badań Żywności PAN

Analytical methods for the determination of contaminants in dairy products using electrochemical multisensors platform w...

Call: DAINA 3 , Panel: NZ7

Principal investigator: dr Krzysztof Robert Noworyta

Instytut Chemii Fizycznej Polskiej Akademii Nauk

Selective inhibition of Janus kinases for the treatment of autoimmune hepatitis: Translational PK/PD modelling from mole...

Call: SONATA 19 , Panel: NZ7

Principal investigator: dr Artur Świerczek

Uniwersytet Jagielloński, Collegium Medicum

Design, synthesis and biological evaluation of Steroid Sulfatase Inhibitors based on organophosphorus compounds.

Call: SONATA 2 , Panel: NZ7

Principal investigator: dr Sebastian Demkowicz

Politechnika Gdańska

Restoring Beta-cell Integrity through Targeted SPOP Inhibition and PDX-1 Preservation

Call: OPUS 26 (LAP) , Panel: NZ7

Principal investigator: dr Anna Czarna

Uniwersytet Jagielloński, Małopolskie Centrum Biotechnologii Uniwersytetu Jagiellońskiego

First-in-class dual modulators of necroptosis kinases and 5-HT6 receptors as an innovative approach to develop an effect...

Call: OPUS 26 , Panel: NZ7

Principal investigator: prof. Jadwiga Handzlik

Uniwersytet Jagielloński, Collegium Medicum

Targeting adenylate kinase 4 (AK4) as a new paradigm in the treatment of non-small cell lung cancer: discovery and evalu...

Call: OPUS 26 , Panel: NZ7

Principal investigator: dr Magdalena Wujak

Uniwersytet Mikołaja Kopernika, Collegium Medicum im. Ludwika Rydygiera w Bydgoszczy

Integrated multi-omics approach to accelerate anticancer drug discovery by targeting metabolic reprogramming in human co...

Call: OPUS 26 , Panel: NZ7

Principal investigator: dr hab. Danuta Dudzik

Gdański Uniwersytet Medyczny, Wydział Farmaceutyczny

Prioritizing diagnostics and therapeutics of human prion diseases through integrative omics

Call: JPND Call 2023 , Panel: NZ2

Principal investigator: prof. Beata Katarzyna Sikorska

Uniwersytet Medyczny w Łodzi, Wydział Lekarski

Compounds modulating function of telomeric proteins TRF1 and TRF2

Call: OPUS 25 , Panel: NZ7

Principal investigator: prof. Maciej Wojciech Bagiński

Politechnika Gdańska, Wydział Chemiczny

"I like to move it, move it" – molecular dynamics-driven optimization of ligand residence time as an opportunity to impr...

Call: OPUS 25 , Panel: NZ7

Principal investigator: dr hab. Sabina Marta Podlewska

Instytut Farmakologii PAN

Designing Active Inhibitors of SARS-CoV-2 Methyltransferases

Call: PRELUDIUM 22 , Panel: NZ7

Principal investigator: Alex Jun Matsuda

Uniwersytet Jagielloński, Małopolskie Centrum Biotechnologii Uniwersytetu Jagiellońskiego

Unveiling the molecular signature underlying resistance to CD19 CAR-T therapy in malignant cells.

Call: PRELUDIUM 22 , Panel: NZ7

Principal investigator: Marta Krawczyk

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

Chemosensors with molecularly imprinted polymers for determination of antiviral active drug substances in body fluids - ...

Call: OPUS 25 , Panel: NZ7

Principal investigator: dr Krzysztof Robert Noworyta

Instytut Chemii Fizycznej Polskiej Akademii Nauk

Blood plasma microRNA profile as a basis for detecting Alzheimer's disease and dementia risk in pre-symptomatic individu...

Call: OPUS 24 , Panel: NZ7

Principal investigator: prof. Urszula Wojda

Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

Precise molecular characterization of circulating tumour cells in patients with triple negative breast cancer using high...

Call: OPUS 24 , Panel: NZ7

Principal investigator: prof. Stefano Volinia

Uniwersytet Warszawski, Centrum Nauk Biologiczno-Chemicznych

The impact of physical activity on brain resilience to chronic stress and the mediating role of blood-brain barrier.

Call: OPUS 24 , Panel: NZ7

Principal investigator: dr Marta Maria Nowacka-Chmielewska

Akademia Wychowania Fizycznego im. Jerzego Kukuczki w Katowicach, Instytut Fizjoterapii i Nauk o Zdrowiu

Novel mechanism of lead toxicity - a perspective of molecular biology

Call: SONATA 2 , Panel: NZ7

Principal investigator: dr Natalia Pawlas

Instytut Medycyny Pracy i Zdrowia Środowiskowego

The assessment of purity and identity confirmation of extracellular vesicles withcapillary electrophoresis

Call: PRELUDIUM 21 , Panel: NZ7

Principal investigator: Aleksandra Steć

Gdański Uniwersytet Medyczny, Wydział Farmaceutyczny

Bionanoparticles with a molecular targeting device as a weapon for breast cancer

Call: OPUS 23 , Panel: NZ7

Principal investigator: prof. Sylwia Anna Rodziewicz-Motowidło

Uniwersytet Gdański, Wydział Chemii

Crystallographic analysis of RNA-ligand complexes. Towards rational design oflead compounds for development of therapies...

Call: OPUS 23 , Panel: NZ7

Principal investigator: dr hab. Agnieszka Ludmiła Kiliszek

Instytut Chemii Bioorganicznej PAN

The evaluation of therapeutic potential of β-caryophyllene in animal schizophrenia model - behavioral and molecular stud...

Call: PRELUDIUM 21 , Panel: NZ7

Principal investigator: dr Magdalena Białoń

Instytut Farmakologii PAN

The application of artificial intelligence to the discovery of new natural drugs with mechanisms aimed at lowering free ...

Call: PRELUDIUM 21 , Panel: NZ7

Principal investigator: Maciej Spiegel

Uniwersytet Medyczny im. Piastów Śląskich we Wrocławiu, Wydział Farmaceutyczny z Oddziałem Analiutyki Medycznej, Wydział Farmaceutyczny

PFAS exposure and premature ovarian insufficiency: molecular mechanism.

Call: OPUS 23 , Panel: NZ7

Principal investigator: dr hab. Anna Ptak

Uniwersytet Jagielloński, Wydział Biologii

Enhancement of antidepressant therapy by combined administration of hyperforin and ketamine: behavioral and molecular st...

Call: SONATA 17 , Panel: NZ7

Principal investigator: dr Bartłomiej Pochwat

Instytut Farmakologii PAN

Understanding the molecular and ecological interactions between viruses and eriophyoid mites

Call: POLONEZ BIS 1 , Panel: NZ9

Principal investigator: dr Tobiasz Zygmunt Druciarek

Szkoła Główna Gospodarstwa Wiejskiego w Warszawie

Identification of low molecular weight compounds and peptides with high biological activity present in maggot secretions...

Call: SONATA 17 , Panel: NZ7

Principal investigator: dr Katarzyna Joanna Papaj

Politechnika Śląska, Centrum Biotechnologii

Search for Inhibitors of Human δ1-Pyrroline-5-Carboxylate Reductase 1 (PYCR1) as Lead Molecules for the Development of N...

Call: OPUS 22 , Panel: NZ7

Principal investigator: dr hab. Miłosz Ruszkowski

Instytut Chemii Bioorganicznej PAN

The interplay of neurochemistry and cancer biology: in the search for novel glioblastoma multiforme therapy among dopami...

Call: SONATA 17 , Panel: NZ7

Principal investigator: dr Katarzyna Maria Kucwaj-Brysz

Uniwersytet Jagielloński, Collegium Medicum

Photoswitchable and chimeric molecules for spatially restricted and endoplasmic reticulum-specific blockade of PD-L1 pro...

Call: SONATA BIS 11 , Panel: NZ7

Principal investigator: dr Łukasz Dariusz Skalniak

Uniwersytet Jagielloński, Wydział Chemii

New graphene-based approach targeting the prion-like propagation of α-synuclein in Parkinson's disease.

Call: SONATA BIS 11 , Panel: NZ7

Principal investigator: dr hab. Małgorzata Kujawska

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu

Blocking the TNF-TNFR2 interactions as a novel approach to the ovarian carcinoma treatment

Call: OPUS 21 , Panel: NZ7

Principal investigator: prof. Sylwia Anna Rodziewicz-Motowidło

Uniwersytet Gdański, Wydział Chemii

In search for molecular targets to overcome doxorubicin resistance in triple-negative breast cancer with the use of inno...

Call: PRELUDIUM 20 , Panel: NZ7

Principal investigator: Anna Karolina Pogorzelska

Narodowy Instytut Leków

Correlations between supramolecular structure, molecular dynamics, physico-chemical stability, and solubility in neat Ac...

Call: OPUS 21 , Panel: NZ7

Principal investigator: dr Karolina Jurkiewicz

UNIWERSYTET ŚLĄSKI, Wydział Nauk Ścisłych i Technicznych

Molecular mechanism of the protective effect of swimming training on skeletal muscle atrophy and the course of amyotroph...

Call: OPUS 20 , Panel: NZ7

Principal investigator: prof. Wiesław Ziółkowski

Gdański Uniwersytet Medyczny, Wydział Nauk o Zdrowiu z Instytutem Medycyny Morskiej i Tropikalnej

Enzymes of the L-methionine biosynthetic pathway as novel moleculartargets for antifungal chemotherapy

Call: OPUS 20 , Panel: NZ7

Principal investigator: dr hab. Iwona Aniela Gabriel

Politechnika Gdańska, Wydział Chemiczny

The study on the molecular mechanisms of cytotoxic activity of new compounds ZOT5-1-Me and ZOT5-1-Et in an experimental ...

Call: SONATA 16 , Panel: NZ7

Principal investigator: dr Paulina Anna Tokarz

Uniwersytet Łódzki, Wydział Biologii i Ochrony Środowiska

Molecular profiling of novel antipsychotic drug candidates

Call: OPUS 20 , Panel: NZ7

Principal investigator: dr hab. Jan Manuel Rodriguez Parkitna

Instytut Farmakologii PAN

Development of an in vitro model for the evaluation of phototoxicity of drugs with different affinity to melanin using a...

Call: SONATA 16 , Panel: NZ7

Principal investigator: dr hab. Jakub Rok

Śląski Uniwersytet Medyczny w Katowicach, Wydział Nauk Farmaceutycznych w Sosnowcu

New 5-HT6 receptor ligands from the group of sulfonamide derivatives of cyclic arylguanidines in the treatment of gliobl...

Call: PRELUDIUM 19 , Panel: NZ7

Principal investigator: dr Przemysław Patryk Zaręba

Politechnika Krakowska im. Tadeusza Kościuszki, Wydział Inżynierii i Technologii Chemicznej

Searching for the molecular bases of mephedrone-induced biphasic response to social interactions in rats

Call: PRELUDIUM 19 , Panel: NZ7

Principal investigator: dr Olga Iga Wronikowska-Denysiuk

Uniwersytet Medyczny w Lublinie, Wydział Nauk Medycznych

Molecular mechanism underlying the anti-inflammatory action of CB2 receptor agonists in microglia: participation of the ...

Call: OPUS 19 , Panel: NZ7

Principal investigator: dr Natalia Eleonora Małek-Chudzik

Politechnika Wrocławska