Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

Delete all

Correlations between supramolecular structure, molecular dynamics, physico-chemical stability, and solubility in neat Active Pharmaceutical Ingredients (APIs) and API-excipient binary systems

2021/41/B/NZ7/01654

Keywords:

amorphous pharmaceuticals supramolecular structures meso-/nanophases molecular dynamics physical and chemical stability solubility active pharmaceutical ingredients binary systems with excipients

Descriptors:

  • NZ7_014:
  • ST3_013:
  • NZ7_016:

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Śląski w Katowicach, Wydział Nauk Ścisłych i Technicznych

woj. śląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Karolina Jurkiewicz 

Number of co-investigators in the project: 9

Call: OPUS 21 - announced on 2021-03-15

Amount awarded: 2 514 176 PLN

Project start date (Y-m-d): 2022-02-07

Project end date (Y-m-d): 2026-02-06

Project duration:: 48 months (the same as in the proposal)

Project status: Pending project

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (9)
  1. The impact of H/D exchange on the thermal and structural properties as well as high‑pressure relaxation dynamics of melatonin
    Authors:
    P. Jesionek, B. Hachuła, D. Heczko, K. Jurkiewicz, M. Tarnacka, M. Zubko, M. Paluch, K. Kamiński, E. Kamińska
    Academic press:
    Scientific Reports (rok: 2022, tom: 12, strony: 14324), Wydawca: Nature
    Status:
    Published
    DOI:
    10.1038/s41598-022-18478-0 - link to the publication
  2. The Effect of Various Poly (N-vinylpyrrolidone) (PVP) Polymers on the Crystallization of Flutamide
    Authors:
    D. Heczko, B. Hachuła, P. Maksym, K. Kamiński, A. Zięba, L. Orszulak, M. Paluch, E. Kamińska
    Academic press:
    Pharmaceuticals (rok: 2022, tom: 15, strony: 971), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ph15080971 - link to the publication
  3. Studies on the nature and pressure evolution of phase transitions in 1-adamantylamine and 1-adamantanol
    Authors:
    P. Jesionek, B. Hachuła, D. Heczko, T. Lamrani, K. Jurkiewicz, M. Tarnacka, M. Książek, K. Kamiński, E. Kamińska
    Academic press:
    Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy (rok: 2023, tom: 299, strony: 45670), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.saa.2023.122794 - link to the publication
  4. Breakdown of isochronal superpositioning of α-and β-relaxation times in the van der Waals system–Loratadine
    Authors:
    D. Heczko, M. Tarnacka, K. Kamiński, M. Paluch, E. Kamińska
    Academic press:
    Journal of Molecular Liquids (rok: 2023, tom: 376, strony: 121377), Wydawca: ScienceDirect
    Status:
    Published
    DOI:
    10.1016/j.molliq.2023.121377 - link to the publication
  5. The impact of H/D exchange on the thermal and structural properties as well as high‑pressure relaxation dynamics of melatonin
    Authors:
    P. Jesionek, B. Hachuła, D. Heczko, K. Jurkiewicz, M. Tarnacka, M. Zubko, M. Paluch, K. Kamiński, E. Kamińska
    Academic press:
    Scientific Reports (rok: 2022, tom: 12, strony: 14324), Wydawca: Nature
    Status:
    Published
    DOI:
    10.1038/s41598-022-18478-0 - link to the publication
  6. Breakdown of isochronal superpositioning of α-and β-relaxation times in the van der Waals system–Loratadine
    Authors:
    D. Heczko, M. Tarnacka, K. Kamiński, M. Paluch, E. Kamińska
    Academic press:
    Journal of Molecular Liquids (rok: 2023, tom: 376, strony: 121377), Wydawca: ScienceDirect
    Status:
    Published
    DOI:
    10.1016/j.molliq.2023.121377 - link to the publication
  7. Mesoporous Matrices as a Promising New Generation of Carriers for Multipolymorphic Active Pharmaceutical Ingredient Aripiprazole
    Authors:
    A. Minecka, M. Tarnacka, K. Jurkiewicz, D. Żakowiecki, K. Kamiński, E. Kamińska
    Academic press:
    Molecular Pharmaceutics (rok: 2023, tom: 20, strony: 5655–5667), Wydawca: ACS
    Status:
    Published
    DOI:
    10.1021/acs.molpharmaceut.3c00524 - link to the publication
  8. High-pressure studies in the supercooled and glassy state of the strongly associated active pharmaceutical ingredient – ticagrelor
    Authors:
    P. Jesionek, D. Heczko, B. Hachula, K. Kamiński, E. Kamińska
    Academic press:
    Scientific Reports (rok: 2023, tom: 13, strony: 45668), Wydawca: Nature
    Status:
    Published
    DOI:
    10.1038/s41598-023-35772-7 - link to the publication
  9. The Effect of Various Poly (N-vinylpyrrolidone) (PVP) Polymers on the Crystallization of Flutamide
    Authors:
    D. Heczko, B. Hachuła, P. Maksym, K. Kamiński, A. Zięba, L. Orszulak, M. Paluch, E. Kamińska
    Academic press:
    Pharmaceuticals (rok: 2022, tom: 15, strony: 971), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ph15080971 - link to the publication

O Narodowym Centrum Nauki

Finansowanie nauki

Współpraca zagraniczna

Centrum prasowe

Deklaracja dostępności
Przetwarzanie danych osobowych
Polityka cookies

Partnerzy