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Development of an in vitro model for the evaluation of phototoxicity of drugs with different affinity to melanin using a solar simulator – the study of cellular, molecular and biochemical mechanisms of the phototoxic reaction

2020/39/D/NZ7/01206

Keywords

Descriptors

  • NZ7_014: Farmacja, farmakoterapia, farmakologia

Panel

NZ7 – Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution

Śląski Uniwersytet Medyczny w Katowicach, Wydział Nauk Farmaceutycznych w Sosnowcu

Voivodeship: śląskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr hab. Jakub Rok

Number of co-investigators in the project: 4

Call

SONATA 16 – announced on 2020-09-15

Amount awarded
1 502 520 PLN
Project start date
2021-07-20
Project end date
2025-02-24
Project duration
44 months (the same as in the proposal)
Project status
Project settled

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

Publication in academic press/journals (1)

  1. The assessment of the phototoxic potential of drugs forming complexes with melanin - Screening in vitro studies using normal skin cells with varying pigmentation irradiated by a sunlight simulator.

    Authors:
    Jakub Rok, Justyna Kowalska , Zuzanna Rzepka , Klaudia Banach , Dorota Wrześniok
    Academic press:
    Chemico-Biological Interactions (year: 2024, volume: 404, pages: 111268 (15 stron)), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.cbi.2024.111268 – link to the publication

Articles in post-conference publications (4)

  1. In vitro model studies of chlorpromazine-induced phototoxicity using normal skin cells with different pigmentation irradiated with a sunshine simulator

    Authors:
    Z. Rzepka, J. Kowalska, K. Banach, J. Rok
    Conference:
    Cell death, and inflammation (year: 2023, volume: 47th FEBS Congress, pages: P-02.2-06), Publisher: FEBS Open Bio
    Date:
    conference 8-12.07.2023
    Status:
    Published
    DOI:
    10.1002/2211-5463.13646 – link to the publication

  2. Disruptions in the homeostasis of normal skin fibroblasts and melanocytes induced by doxycycline phototoxicity – model studies using a sunlight simulator

    Authors:
    J. Rok, Z. Rzepka, K. Banach, J. Kowalska
    Conference:
    Understanding of well-being homeostasis: the role of physical activity (year: 2024, volume: 48th FEBS Congress, pages: P-13-001), Publisher: FEBS Open Bio
    Date:
    conference 29.06-3.07.2024
    Status:
    Published
    DOI:
    10.1002/2211-5463.13837 – link to the publication

  3. Phototoxicity induced by chloroquine – an in vitro study using various experimental models

    Authors:
    Z. Rzepka, J. Kowalska, K. Banach, J. Rok
    Conference:
    Clinical Trials, Preclinical Studies and Basic Research Related to Physical Activity (year: 2024, volume: 48th FEBS Congress, pages: P-12-020), Publisher: FEBS Open Bio
    Date:
    conference 29.06-3.07.2024
    Status:
    Published
    DOI:
    10.1002/2211-5463.13837 – link to the publication

  4. The assessment of the sensitivity of normal skin cells with different pigmentation on cytotoxic and phototoxic effects of doxycycline – in vitro model studies using a sunshine simulator

    Authors:
    J. Rok, Z. Rzepka, K. Banach, J. Kowalska
    Conference:
    Cell death, and inflammation (year: 2023, volume: 47th FEBS Congress, pages: P-02.2-09), Publisher: FEBS Open Bio
    Date:
    conference 8-12.07.2023
    Status:
    Published
    DOI:
    10.1002/2211-5463.13646 – link to the publication

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Graphic design and implementation: Jakub Piotrowski