Projects funded by the NCN
Development of an in vitro model for the evaluation of phototoxicity of drugs with different affinity to melanin using a solar simulator – the study of cellular, molecular and biochemical mechanisms of the phototoxic reaction
2020/39/D/NZ7/01206
Keywords:
Drug phototoxicity melanin oxidative stress normal skin cells
Descriptors:
- NZ7_014:
Panel:
NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology
Host institution :
Śląski Uniwersytet Medyczny w Katowicach, Wydział Nauk Farmaceutycznych w Sosnowcu
woj. śląskie
Principal investigator (from the host institution):
Number of co-investigators in the project: 4
Call: SONATA 16 - announced on 2020-09-15
Amount awarded: 1 502 520 PLN
Project start date (Y-m-d): 2021-07-20
Project end date (Y-m-d): 2024-07-19
Project duration:: 36 months (the same as in the proposal)
Project status: Project completed
Project description
Download the project description in a pdf file
Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Information in the final report
- Publication in academic press/journals (1)
- Articles in post-conference publications (4)
- The assessment of the phototoxic potential of drugs forming complexes with melanin - Screening in vitro studies using normal skin cells with varying pigmentation irradiated by a sunlight simulator.Authors:Jakub Rok, Justyna Kowalska , Zuzanna Rzepka , Klaudia Banach , Dorota WrześniokAcademic press:Chemico-Biological Interactions (rok: 2024, tom: 404, strony: 111268 (15 stron)), Wydawca: ElsevierStatus:PublishedDOI:10.1016/j.cbi.2024.111268 - link to the publication
- In vitro model studies of chlorpromazine-induced phototoxicity using normal skin cells with different pigmentation irradiated with a sunshine simulatorAuthors:Z. Rzepka, J. Kowalska, K. Banach, J. RokConference:Cell death, and inflammation (rok: 2023, tom: 47th FEBS Congress, strony: P-02.2-06), Wydawca: FEBS Open BioData:konferencja 8-12.07.2023Status:PublishedDOI:10.1002/2211-5463.13646 - link to the publication
- Disruptions in the homeostasis of normal skin fibroblasts and melanocytes induced by doxycycline phototoxicity – model studies using a sunlight simulatorAuthors:J. Rok, Z. Rzepka, K. Banach, J. KowalskaConference:Understanding of well-being homeostasis: the role of physical activity (rok: 2024, tom: 48th FEBS Congress, strony: P-13-001), Wydawca: FEBS Open BioData:konferencja 29.06-3.07.2024Status:PublishedDOI:10.1002/2211-5463.13837 - link to the publication
- Phototoxicity induced by chloroquine – an in vitro study using various experimental modelsAuthors:Z. Rzepka, J. Kowalska, K. Banach, J. RokConference:Clinical Trials, Preclinical Studies and Basic Research Related to Physical Activity (rok: 2024, tom: 48th FEBS Congress, strony: P-12-020), Wydawca: FEBS Open BioData:konferencja 29.06-3.07.2024Status:PublishedDOI:10.1002/2211-5463.13837 - link to the publication
- The assessment of the sensitivity of normal skin cells with different pigmentation on cytotoxic and phototoxic effects of doxycycline – in vitro model studies using a sunshine simulatorAuthors:J. Rok, Z. Rzepka, K. Banach, J. KowalskaConference:Cell death, and inflammation (rok: 2023, tom: 47th FEBS Congress, strony: P-02.2-09), Wydawca: FEBS Open BioData:konferencja 8-12.07.2023Status:PublishedDOI:10.1002/2211-5463.13646 - link to the publication