Projects funded by the NCN

Targeted inhibition of STATs and IRFs as a novel treatment strategy in cardiovascular disease

Call: OPUS 9 , Panel: NZ2

Principal investigator: prof. Johannes Antonius Bluijssen (Bluyssen)

Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Biologii

DNA repair pathways contributing to resistance to photodynamic therapy and as possible theraupeutic targets

Call: OPUS 8 , Panel: NZ5

Principal investigator: dr hab. Elżbieta Speina

Instytut Biochemii i Biofizyki PAN

Functional Characterization of Non-Collagenous Extracellular Matrix Proteins as a Potential Molecular Target and Novel B...

Call: SONATA 8 , Panel: NZ5

Principal investigator: dr Michał Andrzej Pawlak

Międzynarodowy Instytut Biologii Molekularnej i Komórkowej

Identification of new, clinically relevant genetic and epigenetic aberrations by next-generation sequencing in chronic m...

Call: HARMONIA 6 , Panel: NZ5

Principal investigator: dr Tomasz Artur Stokłosa

Warszawski Uniwersytet Medyczny, Wydział Lekarski

Analysis of relations on the level of metabolome, miRNome, and transcriptome of human renal cancer: towards identificati...

Call: OPUS 7 , Panel: NZ5

Principal investigator: dr hab. Agnieszka Piekiełko-Witkowska

CENTRUM MEDYCZNE KSZTAŁCENIA PODYPLOMOWEGO

Inhibition of p21-Activated Kinase (PAK) as a new molecular target in the treatment of chronic myeloid leukemia (CML)

Call: OPUS 6 , Panel: NZ7

Principal investigator: dr hab. Sylwia Flis

Narodowy Instytut Leków

Disorders of metabolic pathways in breast cancer cells in population of postmenopausal women

Call: PRELUDIUM 5 , Panel: NZ5

Principal investigator: Łukasz Kwinta

Wielkopolskie Centrum Onkologii

Targeted genomics of cardiovascular disease - multivariable genetic model of perioperative and long-term cardiovascular ...

Call: OPUS 5 , Panel: NZ5

Principal investigator: prof. Marek Jan Sanak

Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Lekarski

Non-targeted metabolite fingerprinting of biological sample using gas chromatography with mass spectrometry detector

Call: PRELUDIUM 4 , Panel: NZ5

Principal investigator: Arlette Yumba Mpanga

Gdański Uniwersytet Medyczny, Wydział Farmaceutyczny z Oddziałem Medycyny Laboratoryjnej

Identification of triple negative breast cancer with inactive DNA damage repair pathway by homologous recombination base...

Call: SONATA 3 , Panel: NZ5

Principal investigator: dr Paweł Wenancjusz Domagała

Pomorski Uniwersytet Medyczny w Szczecinie, Wydział Lekarski z Oddziałem Nauczania w Języku Angielskim

Targeted DNA Capture and Next Generation Sequencing to identify mutations responsible for hearing impairment

Call: SONATA 2 , Panel: NZ5

Principal investigator: dr Agnieszka Pollak

Instytut Fizjologii i Patologii Słuchu

Next-Generation Exosome Therapy: Engineering NK Cell-Derived Vesicles for Targeted Cancer Treatment

Call: SONATINA 9 , Panel: NZ6

Principal investigator: dr Daria Nawrocka

Instytut Immunologii i Terapii Doświadczalnej im. Ludwika Hirszfelda Polskiej Akademii Nauk

Identifying early biomarkers and molecular targets for therapeutic intervention in right ventricular dysfunction

Call: OPUS 28 , Panel: NZ5

Principal investigator: prof. Przemysław Błyszczuk

Uniwersytet Jagielloński

Selective autophagy-mediated protein degradation as a potential therapeutic strategy for the treatment of inflammatory c...

Call: OPUS 28 , Panel: NZ7

Principal investigator: dr hab. Monika Emilia Marcinkowska

Uniwersytet Jagielloński

Where Inhibition is not Enough- Development of Innovative Compounds for Targeted Degradation of Extracellular and Membra...

Call: OPUS 28 (LAP) , Panel: NZ5

Principal investigator: dr Marcin Skoreński

Politechnika Wrocławska

Quad-TNT: Quadruplex-Targeted Photo-Therapy for Triple-Negative Tumors

Call: SONATA BIS 14 , Panel: NZ5

Principal investigator: dr Marco Deiana

Politechnika Wrocławska

M6A RNA methylation signatures as a targets for HPV-dependent HNSCC therapy

Call: OPUS 27 , Panel: NZ5

Principal investigator: Kamila Ostrowska

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu

Identification of circulating biomarkers for monitoring anti-CD19 CAR-T cell treatment response in patients with aggress...

Call: PRELUDIUM 23 , Panel: NZ5

Principal investigator: Monika Szelest

Uniwersytet Medyczny w Lublinie

Precision double strike against non-small cell lung cancer. Insights into multidirectional therapies and the landscape o...

Call: OPUS 27 , Panel: NZ5

Principal investigator: dr Katarzyna Anna Malarz

Politechnika Śląska

Neutrophil-targeted immune response as an effective approach in immunotherapyof gastrointestinal cancers

Call: OPUS 27 , Panel: NZ5

Principal investigator: dr Damian Jacenik

Uniwersytet Łódzki

Proteomic predictors of metastasis in colorectal cancer – a validation study

Call: OPUS 27 , Panel: NZ5

Principal investigator: dr hab. Anna Wojakowska

Instytut Chemii Bioorganicznej PAN

Modulation of protein interaction networks as a new therapeutic target in the treatment of hereditary retinal dystrophie...

Call: SONATA 19 , Panel: NZ5

Principal investigator: dr Xiaonan Liu

Śląski Uniwersytet Medyczny w Katowicach, Wydział Nauk Medycznych w Katowicach

The inhibition of NMDAR and TRPM4 coupling - a hope for novel therapeutic target for the treatment of the ischemic brain...

Call: SONATA BIS 13 , Panel: NZ7

Principal investigator: dr Bartosz Sebastian Pomierny

Uniwersytet Jagielloński, Collegium Medicum

Deciphering the Chemoproteomics and Chemotranscriptomics of Anti-Alzheimer Drugs for Novel Druggable Target Identificati...

Call: JPND Call 2023 , Panel: NZ5

Principal investigator: prof. Krzysztof Sobczak

Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Biologii

Extensive analysis of the immunological profile of pediatric patients with acute lymphoblastic leukemia in order to iden...

Call: PRELUDIUM 22 , Panel: NZ5

Principal investigator: Anna Krętowska-Grunwald

Uniwersytet Medyczny w Białymstoku

Curdlan-based biomaterial as a nanostructure carrier for controlled and targeted drug delivery in the treatment of deep ...

Call: PRELUDIUM 22 , Panel: NZ7

Principal investigator: dr Aleksandra Nurzyńska

Uniwersytet Medyczny w Lublinie

Cuproptosis, a novel pathway of regulated cell death as a therapeutic target in treatment-naïve and targeted therapy-res...

Call: OPUS 25 , Panel: NZ5

Principal investigator: dr hab. Mariusz Łukasz Hartman

Uniwersytet Medyczny w Łodzi, Wydział Lekarski

Endothelial bioenergetics as a novel target for vascular protection – unveiling the mitochondrial mechanisms of lipid-lo...

Call: PRELUDIUM 22 , Panel: NZ5

Principal investigator: dr Alicja Małgorzata Braczko

Gdański Uniwersytet Medyczny, Wydział Lekarski

The Role of the Mitochondrial Unfolded Protein Response (UPRmt) in Endothelial Function: a Possible Novel Target for the...

Call: PRELUDIUM 22 , Panel: NZ7

Principal investigator: Sylwester Tycjan Mosiołek

Uniwersytet Jagielloński, Jagiellońskie Centrum Rozwoju Leków (JCET)

Investigating the role of fibroblast growth factor receptors and STAT transcription factors in the targeted therapy of a...

Call: PRELUDIUM BIS 4 , Panel: NZ5

Principal investigator: prof. Ewa Teresa Marcinkowska

Uniwersytet Wrocławski, Wydział Biotechnologii

Molecular insights into hypoxic tumors – for development of targeted cancer therapeutics

Call: POLONEZ BIS 3 , Panel: NZ5

Principal investigator: dr Marco Deiana

Politechnika Wrocławska

Modifiers of Muscleblind-like genes expression in health and disease.

Call: SONATA BIS 12 , Panel: NZ5

Principal investigator: dr hab. Ewa Agnieszka Stępniak-Konieczna

Uniwersytet Przyrodniczy w Poznaniu, Wydział Rolnictwa, Ogrodnictwa i Biotechnologii

Brain cytochrome P450 as a new target for the treatment of neurological and psychiatric diseases. Studies with human neu...

Call: OPUS 23 , Panel: NZ7

Principal investigator: prof. Władysława Anna Daniel

Instytut Farmakologii PAN

The role of simultaneous and individual modulation of μ-opioid, sigma-1 and histamine H3 receptors as a new therapeutic ...

Call: OPUS 23 , Panel: NZ7

Principal investigator: dr Katarzyna Anna Szczepańska

Instytut Farmakologii PAN

Targeting of metabolic and transcriptomic cross-talk between leukemic cells and macrophages as a therapeutic strategy in...

Call: OPUS 22 , Panel: NZ5

Principal investigator: dr Baran Natalia

Instytut Hematologii i Transfuzjologii

The role of NPM1 as biomarker of the targeted therapy efficacy in chronic lymphocytic leukemia patients

Call: PRELUDIUM BIS 3 , Panel: NZ5

Principal investigator: prof. Krzysztof Georgios Giannopoulos

Uniwersytet Medyczny w Lublinie, Wydział Lekarski

Role of RelA(p65) and cRel phosphorylations and their kinases in the biology of Diffuse-large B-cell lymphoma and Hodgki...

Call: OPUS 22 , Panel: NZ5

Principal investigator: dr Maciej Stefan Szydłowski

Instytut Hematologii i Transfuzjologii

In the search of specific oxylipin fingerprint reflecting the development of endothelial dysfunction with the use of non...

Call: SONATA 17 , Panel: NZ5

Principal investigator: dr Agnieszka Róża Kij

Uniwersytet Jagielloński, Jagiellońskie Centrum Rozwoju Leków (JCET)

New strategies in the treatment of non-small cell lung cancer based on silk nanocarriers targeting tumor vascularization

Call: SONATA 17 , Panel: NZ7

Principal investigator: dr Anna Katarzyna Florczak-Substyk

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu

Chronic pain in obesity: from cellular mechanisms to new strategies for targeted therapy.

Call: SONATA 17 , Panel: NZ5

Principal investigator: dr Anna Piotrowska-Murzyn

Instytut Farmakologii PAN

ATHENA Study - ArTerial HypErtension PAthogenesis - microRNA as a missing link of the disease development in children.

Call: PRELUDIUM 20 , Panel: NZ5

Principal investigator: Michał Szyszka

Warszawski Uniwersytet Medyczny, Wydział Lekarski

Functional framework for viral RNA-dependent RNA polymerase, a major target in COVID19 treatment

Call: Polskie Powroty NAWA 2020 COVID-19 , Panel: NZ1

Principal investigator: dr Tomasz Wojciech Turowski

Instytut Biochemii i Biofizyki PAN

Identification of the interdependence between SWI/SNF-type chromatin remodeling complex, metabolism control and RNA modi...

Call: OPUS 20 , Panel: NZ5

Principal investigator: prof. Tomasz Jacek Sarnowski

Instytut Biochemii i Biofizyki PAN

The use of surface proteins to capture cancer cells with functionalized magnetic nanoparticles as an innovative theranos...

Call: OPUS 20 , Panel: NZ5

Principal investigator: dr hab. Joanna Danuta Dulińska-Litewka

Uniwersytet Jagielloński, Collegium Medicum

Identification of potential markers aiming early diagnostics of progression and tailoring metastasis-oriented therapies ...

Call: OPUS 20 , Panel: NZ5

Principal investigator: dr Natalia Bednarz-Knoll

Gdański Uniwersytet Medyczny, Międzyuczelniany Wydział Biotechnologii Uniwersytetu Gdańskiego i Gdańskiego Uniwersytetu Medycznego

The significance of circadian rhythm in urinary bladder cancer: deregulation of circadian genes as a putative therapeuti...

Call: OPUS 19 , Panel: NZ5

Principal investigator: prof. Edyta Wiesława Reszka

Uniwersytet Łódzki, Wydział Biologii i Ochrony Środowiska

Understanding of the mesenchymal stem cells (MSCs)-mediated immune suppression mechanism in the neutrophilic experimenta...

Call: PRELUDIUM 19 , Panel: NZ5

Principal investigator: dr Marlena Tynecka

Uniwersytet Medyczny w Białymstoku, Wydział Lekarski z Oddziałem Stomatologii i Oddziałem Nauczania w Języku Angielskim

Dynamina-2 jako potencjalny cel terapeutyczny w chłoniaku rozlanym z dużych komórek B

Call: SONATA 15 , Panel: NZ5

Principal investigator: dr Patryk Górniak

Instytut Hematologii i Transfuzjologii

New insights into multifaceted targeted therapy for treatment of glioblastoma multiforme.

Call: OPUS 18 , Panel: NZ5

Principal investigator: dr Katarzyna Anna Malarz

UNIWERSYTET ŚLĄSKI, Wydział Nauk Ścisłych i Technicznych

Physical exercise as a natural mechanism inducing neuroregeneration. Search for the new protein markers and therapeutic ...

Call: OPUS 18 , Panel: NZ7

Principal investigator: dr hab. Katarzyna Zofia Kuter-Nowak

Instytut Farmakologii PAN