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Functional Characterization of Non-Collagenous Extracellular Matrix Proteins as a Potential Molecular Target and Novel Biomarker of Liver Fibrosis

2014/15/D/NZ5/03421

Keywords

Descriptors

  • NZ4_4: Patofizjologia ogólna
  • NZ5_7: Leczenie chorób człowieka
  • NZ2_2: Genomika, transkryptomika i epigenomika

Panel

NZ5 – Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution

Międzynarodowy Instytut Biologii Molekularnej i Komórkowej

Voivodeship: mazowieckie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr Michał Andrzej Pawlak

Number of co-investigators in the project: 1

Call

SONATA 8 – announced on 2014-09-15

Amount awarded
541 875 PLN
Project start date
2015-09-02
Project end date
2019-03-01
Project duration
42 months (the same as in the proposal)
Project status
Project settled

Information in the final report

Publication in academic press/journals (4)

  1. Multi-omics analyses of early liver injury reveals cell-type-specific transcriptional and epigenomic shift

    Authors:
    Maciej Migdał, Eugeniusz Tralle, Karim Abu Nahia, Łukasz Bugajski, Katarzyna Zofia Kędzierska, Filip Garbicz , Katarzyna Piwocka, Cecilia Lanny Winata, Michał Pawlak
    Academic press:
    BMC Genomics (year: 2021, volume: 22, pages: 904), Publisher: Springer Nature
    Status:
    Published
    DOI:
    10.1186/s12864-021-08173-1 – link to the publication

  2. Dynamics of cardiomyocyte transcriptome and chromatin landscape demarcates key events of heart development.

    Authors:
    Pawlak M, Kedzierska KZ, Migdal M, Nahia KA, Ramilowski JA, Bugajski L, Hashimoto K, Marconi A, Piwocka K, Carninci P, Winata CL
    Academic press:
    Genome Research (year: 2019, volume: 23(3), pages: 506-519), Publisher: Cold Spring Harbor Laboratory Press
    Status:
    Published
    DOI:
    10.1101/gr.244491.118 – link to the publication

  3. PPARs in obesity-induced T2DM, dyslipidaemia and NAFLD

    Authors:
    Barbara Gross, Michal Pawlak, Philippe Lefebvre, Bart Staels
    Academic press:
    Nature Reviews Endocrinology (year: 2017, volume: 13, pages: 36–49), Publisher: Springer Nature
    Status:
    Published
    DOI:
    10.1038/nrendo.2016.135 – link to the publication

  4. Interspecies NASH disease activity whole-genome profiling identifies a fibrogenic role of PPARα-regulated dermatopontin

    Authors:
    Philippe Lefebvre, Fanny Lalloyer, Eric Baugé, Michal Pawlak, Céline Gheeraert, Hélène Dehondt, Jonathan Vanhoutte, Eloise Woitrain, Nathalie Hennuyer, Claire Mazuy, Marie Bobowski-Gérard, Francesco Paolo Zummo, Bruno Derudas, Ann Driessen, Guy Hubens, Luisa Vonghia, Wilhelmus J. Kwanten, Peter Michielsen, Thomas Vanwolleghem, Jérôme Eeckhoute, An Verrijken, Luc Van Gaal, Sven Francque, and Bart Staels
    Academic press:
    JCI Insight (year: 2017, volume: 2(13), pages: 46039), Publisher: American Society for Clinical Investigation
    Status:
    Published
    DOI:
    10.1172/jci.insight.92264 – link to the publication

Articles in post-conference publications (1)

  1. Fishing for novel targets of liver fibrosis by using danio rerio model

    Authors:
    Michal Pawlak, Katarzyna Kedzierska, Cecilia Winata
    Conference:
    LIVER FIBROSIS: THE NEXT GOAL OF TARGETED THERAPY? (year: 2016, pages: 119-120), Publisher: European Association for the Study of the Liver
    Date:
    conference 17-18 JUNE
    Status:
    Published

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