Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Targeted inhibition of STATs and IRFs as a novel treatment strategy in cardiovascular disease

2015/17/B/NZ2/00967

Keywords:

STAT IRF homology modeling drug discovery atherosclerosis

Descriptors:

  • NZ2_7: Bioinformatics
  • NZ1_9: Biotechnology
  • NZ1_4: Structural biology

Panel:

NZ2 - Genetics, genomics: molecular genetics, genomics, proteomics, bioinformatics, systems biology, genetic epidemiology

Host institution :

Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Biologii

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Johannes Bluijssen (Bluyssen) 

Number of co-investigators in the project: 6

Call: OPUS 9 - announced on 2015-03-16

Amount awarded: 1 206 340 PLN

Project start date (Y-m-d): 2016-02-08

Project end date (Y-m-d): 2019-11-07

Project duration:: 45 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Pakiet obliczeniowy Gaussian 09 + GaussView 5.0 (12 500 PLN)
  2. Stacja robocza: komputer wieloprocesorowy z monitorem (15 000 PLN)
  3. Stacja robocza: komputer wieloprocesorowy z monitorem (6 000 PLN)
  4. Licencja akademicka PyMol + AxPyMol (5 000 PLN)
  5. Real Time PCR - CFX96™ Touch System firmy BioRad.
  6. Pakiet ChemOffice Professional 15 firmy CambridgeSoft (3 000 PLN)

Information in the final report

  • Publication in academic press/journals (4)
  • Book publications / chapters in book publications (1)
  1. Editorial: STATs and IRFs in Innate Immunity: From Transcriptional Regulators to Therapeutic Targets
    Authors:
    Chien-Kuo Lee and Hans A. R. Bluyssen
    Academic press:
    Frontiers in Immunology (rok: 2019, tom: 10, strony: 1829), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fimmu.2019.01829 - link to the publication
  2. Direct inhibition of IRF-dependent transcriptional regulatory mechanisms associated with disease
    Authors:
    Aleksandra M. Antończyk, Bart Krist, Malgorzata Szelag, Agata Michalska, Anna Piaszyk- Borychowska, Martyna Plens- Galaska, Joanna Wesoly, Hans A. Bluyssen
    Academic press:
    Frontiers in Immunology (rok: 2019, tom: 10, strony: 1176), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fimmu.2019.01176 - link to the publication
  3. Genome-Wide Inhibition of Pro-Atherogenic Gene Expression by Multi-STAT Targeting Compounds as a Novel Treatment Strategy of CVD
    Authors:
    Martyna Plens-Galaska, Malgorzata Szelag, Aida Collado, Patrice Marques, Susana Vallejo, Mariella Ramos-González, Joanna Wesoly, Maria Jesus Sanz, Concepción Peiró, Hans A.R. Bluyssen.
    Academic press:
    Frontiers in Immunology (rok: 2018, tom: 9, strony: 2141), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fimmu.2018.02141 - link to the publication
  4. Signal Integration of IFN-I and IFN-II with TLR4 involves sequential recruitment of STAT1-complexes and NFκB to enhance pro-inflammatory transcription
    Authors:
    Anna Piaszyk-Borychowska, Lajos Széles, Attila Csermely, Hsin-Chien Chiang, Joanna Wesoły, Chien-Kuo Lee, Laszlo Nagy and Hans A.R. Bluyssen
    Academic press:
    Frontiers in Immunology (rok: 2019, tom: 10, strony: 1253), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fimmu.2019.01253 - link to the publication
  1. eBook: STATs and IRFs in Innate Immunity: From Transcriptional Regulators to Therapeutic Targets
    Authors:
    editors: Chien-Kuo Lee and Hans A. R. Bluyssen
    Book:
    eBook: STATs and IRFs in Innate Immunity: From Transcriptional Regulators to Therapeutic Targets (rok: 2019, tom: n/d, strony: 1-219), Wydawca: Frontiers in Immunology
    Status:
    Published

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