Projects funded by the NCN

Activity of the opioid system in the pathogenesis and therapy of inflammatory disorders in mouse lines with high and low...

Call: OPUS 7 , Panel: NZ4

Principal investigator: dr hab. Jakub Fichna

Uniwersytet Medyczny w Lodzi, Wydział Lekarski

Impact of opioid-neurotensin chimera (PK20) on inflammation in murine model of contact sensitivity reaction and non-atho...

Call: OPUS 7 , Panel: NZ7

Principal investigator: dr hab. Katarzyna Kaczyńska

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

Fentanyl opioid designer drugs: from molecular modeling to in vitro studies

Call: OPUS 6 , Panel: ST4

Principal investigator: prof. Joanna Sadlej

Narodowy Instytut Leków

The role of endogenous opioid system in the pathogenesis and treatment of inflammatory bowel diseases and colitis-associ...

Call: PRELUDIUM 6 , Panel: NZ7

Principal investigator: dr Marta Zielińska

Uniwersytet Medyczny w Łodzi, Wydział Lekarski

Synthesis and pharmacological characterization of novel cyclic opioid peptide analogs incorporating fluoro amino acids.

Call: PRELUDIUM 5 , Panel: NZ7

Principal investigator: dr Justyna Piekielna-Ciesielska

Uniwersytet Medyczny w Łodzi, Wydział Lekarski

Identification of the crucial metabolic pathways in the central nervous system in the patophysiology of opioid dependenc...

Call: OPUS 4 , Panel: NZ4

Principal investigator: dr hab. Piotr Suder

Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie, Wydział Inżynierii Materiałowej i Ceramiki

Neural mechanisms underlying pathology of motivation.

Call: SONATA BIS 2 , Panel: NZ3

Principal investigator: dr Jan Rodriguez-Parkitna

Instytut Farmakologii PAN

Examine the importance of intracellular pathways in the action of opioids in microglial cells in vitro

Call: PRELUDIUM 4 , Panel: NZ3

Principal investigator: Katarzyna Popiołek-Barczyk

Instytut Farmakologii PAN

Activation of endogenous pronociceptive mechanisms of opioid system as an important factors in the development of neurop...

Call: MAESTRO 3 , Panel: NZ4

Principal investigator: prof. Barbara Przewłocka

Instytut Farmakologii PAN

Investigation of neuroprotective potency and mechanism of action of opioid-neurotensin hybrid peptides in organotypic hi...

Call: PRELUDIUM 2 , Panel: NZ4

Principal investigator: dr Patrycja Kleczkowska

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

Structure-activity relationship of bifunctional peptides, agonists of opioid receptors and antagonists of neurokinin rec...

Call: PRELUDIUM 2 , Panel: ST5

Principal investigator: Jolanta Dyniewicz

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

Synthesis of deltorphin I and dermorphin analogues modified with alfa-alkyl-beta-azido(amino)alanine in postion 2 or 3.

Call: PRELUDIUM 2 , Panel: ST5

Principal investigator: Anika Lasota

POLITECHNIKA ŁÓDZKA, Politechnika Łódzka, Wydział Chemiczny,

Study of ligand binding and activation processes of formyl, opioid and cannabinoid G-protein-coupled receptors

Call: OPUS 2 , Panel: NZ1

Principal investigator: prof. Sławomir Filipek

Uniwersytet Warszawski, Wydział Chemii

The developmental changes in the endogenous opioid system associated with altered sensitivity to reward during adolescen...

Call: PRELUDIUM 21 , Panel: NZ4

Principal investigator: Klaudia Misiołek

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

The role of simultaneous and individual modulation of μ-opioid, sigma-1 and histamine H3 receptors as a new therapeutic ...

Call: OPUS 23 , Panel: NZ7

Principal investigator: dr Katarzyna Szczepańska

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

New strategies in the pharmacotherapy of neuropathic pain based on modulation of the chemokine system and its influence ...

Call: OPUS 22 , Panel: NZ7

Principal investigator: prof. Joanna Mika

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

Chronic pain in obesity: from cellular mechanisms to new strategies for targeted therapy.

Call: SONATA 17 , Panel: NZ5

Principal investigator: dr Anna Piotrowska-Murzyn

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

Neurobiological mechanisms of migraine pain - role of opioid and NOP systems

Call: SONATA BIS 11 , Panel: NZ7

Principal investigator: dr Katarzyna Targowska-Duda

Uniwersytet Medyczny w Lublinie

Role of opioid receptors in arterial hypertension. Examination of hypotensive action of biphalin, a synthetic non-addtic...

Call: OPUS 2 , Panel: NZ4

Principal investigator: prof. Janusz Sadowski

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

Opioid receptors in the basal ganglia of the brain as targets for alcohol abuse therapy.

Call: OPUS 2 , Panel: NZ4

Principal investigator: dr Jan Rodriguez Parkitna

Instytut Farmakologii PAN

New therapies of opioid use disorder

Call: OPUS 20 , Panel: NZ7

Principal investigator: dr Wojciech Solecki

Uniwersytet Jagielloński, Wydział Zarządzania i Komunikacji Społecznej

Expression and function of Regulator of G Protein Signaling (RGS) proteins in physiological and pathophysiological condi...

Call: SONATA 16 , Panel: NZ7

Principal investigator: dr hab. Maciej Sałaga

Uniwersytet Medyczny w Łodzi

Exploring new drug targets for efficacious therapy of neuropathic pain basing on the assessment and modulation of neuroi...

Call: OPUS 2 , Panel: NZ4

Principal investigator: dr hab. Joanna Mika

Instytut Farmakologii PAN

Investigation of novel functionally selective opioid receptors agonists

Call: ETIUDA 8 , Panel: NZ7

Principal investigator: Łucja Kudła

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

Synthetic analogues of opioid growth factor linked to derivatives of glucosamine as a potential compounds for targeted t...

Call: OPUS 18 , Panel: NZ7

Principal investigator: dr hab. Iwona Inkielewicz-Stępniak

Gdański Uniwersytet Medyczny, Wydział Lekarski

Kappa opioid receptors integrate neuronal signaling involved in social behavior

Call: OPUS 18 , Panel: NZ7

Principal investigator: dr hab. Jan Rodriguez Parkitna

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

The role of kappa opioid receptors during chronic intestinal inflammation and colitis-associated colorectal cancer – foc...

Call: SONATA 15 , Panel: NZ7

Principal investigator: dr Marta Zielińska

Uniwersytet Medyczny w Łodzi, Wydział Lekarski

The effect of Hmmr gene and its interaction with the endogenous opioid system as a novel mechanism and a therapeutic tar...

Call: SONATA 15 , Panel: NZ5

Principal investigator: dr Dominik Skiba

Instytut Genetyki i Hodowli Zwierząt Polskiej Akademii Nauk

Effects of a novel nonaddictive opioid on response to stress

Call: PRELUDIUM 17 , Panel: NZ7

Principal investigator: Łucja Kudła

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

Rational design and evaluation of functionally biased opioid agonists

Call: OPUS 16 , Panel: NZ7

Principal investigator: prof. Ryszard Przewłocki

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

Searching for mu opioid receptor peptide agonists with G protein/beta-arrestin biased profile and their pharmacological ...

Call: SONATA 14 , Panel: ST5

Principal investigator: dr Justyna Piekielna-Ciesielska

Uniwersytet Medyczny w Łodzi, Wydział Lekarski

New strategies in neuropathic pain pharmacotherapy based on the modulation of the functions of chemokine receptors CCR2 ...

Call: PRELUDIUM 15 , Panel: NZ7

Principal investigator: dr Klaudia Kwiatkowski

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

Correlation between experimental and theoretical NMR shielding parameters for order and disorder molecular crystals of s...

Call: PRELUDIUM 1 , Panel: ST4

Principal investigator: Tomasz Pawlak

CENTRUM BADAŃ MOLEKULARNYCH I MAKROMOLEKULARNYCH PAN

Opioid-induced analgesia and hyperalgesia in neuropathic pain - mechanisms and druggable targets

Call: OPUS 15 , Panel: NZ7

Principal investigator: prof. Barbara Przewłocka

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

MOLECULAR DETERMINANTS OF SIGNAL PROPAGATION IN THE DELTA AND MU OPIOID RECEPTORS - IN SEARCH FOR ANALGETICS WITH LESS S...

Call: PRELUDIUM 14 , Panel: NZ2

Principal investigator: Tomasz Stepniewski

Uniwersytet Warszawski, Wydział Chemii

Determination of the mechanisms and potential targets for neuropathic pain therapy by investigating pharmacological inte...

Call: PRELUDIUM 12 , Panel: NZ7

Principal investigator: Anna Piotrowska-Murzyn

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

The role of endogenous opioid peptides in the local regulation of prolactin secretion from the anterior pituitary in cyc...

Call: PRELUDIUM 1 , Panel: NZ9

Principal investigator: dr Kinga Tworus

UNIWERSYTET WARMIŃSKO-MAZURSKI W OLSZTYNIE, WYDZIAŁ BIOLOGII

The role of the endogenuous opioid system in prosocial behavior

Call: OPUS 11 , Panel: NZ4

Principal investigator: dr hab. Jan Rodriguez Parkitna

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

Search for new targets for an effective therapy of neuropathic pain and enhancement of opioids effects basing on the exa...

Call: OPUS 11 , Panel: NZ4

Principal investigator: prof. Joanna Mika

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

Gene and protein analysis of OPRM1/MOR and OPRK1/KOR opioid receptors expression and neurobiological marker of nerve ter...

Call: PRELUDIUM 1 , Panel: NZ4

Principal investigator: Piotr Kupczyk

Instytut Immunologii i Terapii Doświadczalnej im. Ludwika Hirszfelda PAN

Rational design and pharmacological characterization of chimeric cyclic opioid peptide analogs targeting multiple recept...

Call: OPUS 9 , Panel: ST5

Principal investigator: prof. Anna Janecka

Uniwersytet Medyczny w Łodzi, Wydział Lekarski