Projects funded by the NCN

NMR Spectroscopy as Molecular Language: A Deep Learning Approach to Bioactivity Prediction

Call: PRELUDIUM 24 , Panel: NZ7

Principal investigator: Arkadiusz Bogumił Leniak

Instytut Farmakologii PAN

"I like to move it, move it" – molecular dynamics-driven optimization of ligand residence time as an opportunity to impr...

Call: OPUS 25 , Panel: NZ7

Principal investigator: dr hab. Sabina Marta Podlewska

Instytut Farmakologii PAN

The developmental changes in the endogenous opioid system associated with altered sensitivity to reward during adolescen...

Call: PRELUDIUM 21 , Panel: NZ4

Principal investigator: Klaudia Weronika Misiołek

Instytut Farmakologii PAN

The role of simultaneous and individual modulation of μ-opioid, sigma-1 and histamine H3 receptors as a new therapeutic ...

Call: OPUS 23 , Panel: NZ7

Principal investigator: dr Katarzyna Anna Szczepańska

Instytut Farmakologii PAN

New strategies in the pharmacotherapy of neuropathic pain based on modulation of the chemokine system and its influence ...

Call: OPUS 22 , Panel: NZ7

Principal investigator: prof. Joanna Gabriela Mika

Instytut Farmakologii PAN

Chronic pain in obesity: from cellular mechanisms to new strategies for targeted therapy.

Call: SONATA 17 , Panel: NZ5

Principal investigator: dr Anna Piotrowska-Murzyn

Instytut Farmakologii PAN

Neurobiological mechanisms of migraine pain - role of opioid and NOP systems

Call: SONATA BIS 11 , Panel: NZ7

Principal investigator: dr hab. Katarzyna Małgorzata Targowska-Duda

Uniwersytet Medyczny w Lublinie

New therapies of opioid use disorder

Call: OPUS 20 , Panel: NZ7

Principal investigator: dr Wojciech Barnaba Solecki

Uniwersytet Jagielloński, Wydział Zarządzania i Komunikacji Społecznej

Expression and function of Regulator of G Protein Signaling (RGS) proteins in physiological and pathophysiological condi...

Call: SONATA 16 , Panel: NZ7

Principal investigator: dr hab. Maciej Stawnisław Sałaga

Uniwersytet Medyczny w Łodzi

Investigation of novel functionally selective opioid receptors agonists

Call: ETIUDA 8 , Panel: NZ7

Principal investigator: Łucja Elżbieta Szumiec

Instytut Farmakologii PAN

Synthetic analogues of opioid growth factor linked to derivatives of glucosamine as a potential compounds for targeted t...

Call: OPUS 18 , Panel: NZ7

Principal investigator: prof. Iwona Maria Inkielewicz-Stępniak

Gdański Uniwersytet Medyczny, Wydział Farmaceutyczny

Kappa opioid receptors integrate neuronal signaling involved in social behavior

Call: OPUS 18 , Panel: NZ7

Principal investigator: dr hab. Jan Manuel Rodriguez Parkitna

Instytut Farmakologii PAN

The role of kappa opioid receptors during chronic intestinal inflammation and colitis-associated colorectal cancer – foc...

Call: SONATA 15 , Panel: NZ7

Principal investigator: dr Marta Zielińska

Uniwersytet Medyczny w Łodzi, Wydział Lekarski

The effect of Hmmr gene and its interaction with the endogenous opioid system as a novel mechanism and a therapeutic tar...

Call: SONATA 15 , Panel: NZ5

Principal investigator: dr Dominik Stanisław Skiba

Instytut Genetyki i Hodowli Zwierząt PAN

Effects of a novel nonaddictive opioid on response to stress

Call: PRELUDIUM 17 , Panel: NZ7

Principal investigator: dr Łucja Elżbieta Szumiec

Instytut Farmakologii PAN

Rational design and evaluation of functionally biased opioid agonists

Call: OPUS 16 , Panel: NZ7

Principal investigator: prof. Ryszard Przewłocki

Instytut Farmakologii PAN

Searching for mu opioid receptor peptide agonists with G protein/beta-arrestin biased profile and their pharmacological ...

Call: SONATA 14 , Panel: ST5

Principal investigator: dr Justyna Piekielna-Ciesielska

Uniwersytet Medyczny w Łodzi, Wydział Lekarski

New strategies in neuropathic pain pharmacotherapy based on the modulation of the functions of chemokine receptors CCR2 ...

Call: PRELUDIUM 15 , Panel: NZ7

Principal investigator: dr Klaudia Kwiatkowski

Instytut Farmakologii PAN

Opioid-induced analgesia and hyperalgesia in neuropathic pain - mechanisms and druggable targets

Call: OPUS 15 , Panel: NZ7

Principal investigator: prof. Barbara Elżbieta Przewłocka

Instytut Farmakologii PAN

MOLECULAR DETERMINANTS OF SIGNAL PROPAGATION IN THE DELTA AND MU OPIOID RECEPTORS - IN SEARCH FOR ANALGETICS WITH LESS S...

Call: PRELUDIUM 14 , Panel: NZ2

Principal investigator: Tomasz Maciej Stepniewski

Uniwersytet Warszawski, Wydział Chemii

Determination of the mechanisms and potential targets for neuropathic pain therapy by investigating pharmacological inte...

Call: PRELUDIUM 12 , Panel: NZ7

Principal investigator: Anna Piotrowska-Murzyn

Instytut Farmakologii PAN

The role of the endogenuous opioid system in prosocial behavior

Call: OPUS 11 , Panel: NZ4

Principal investigator: dr hab. Jan Manuel Rodriguez Parkitna

Instytut Farmakologii PAN

Search for new targets for an effective therapy of neuropathic pain and enhancement of opioids effects basing on the exa...

Call: OPUS 11 , Panel: NZ4

Principal investigator: prof. Joanna Gabriela Mika

Instytut Farmakologii PAN

Rational design and pharmacological characterization of chimeric cyclic opioid peptide analogs targeting multiple recept...

Call: OPUS 9 , Panel: ST5

Principal investigator: prof. Anna Ewa Janecka

Uniwersytet Medyczny w Łodzi, Wydział Lekarski

Activity of the opioid system in the pathogenesis and therapy of inflammatory disorders in mouse lines with high and low...

Call: OPUS 7 , Panel: NZ4

Principal investigator: dr hab. Jakub Jerzy Fichna

Uniwersytet Medyczny w Łodzi, Wydział Lekarski

Impact of opioid-neurotensin chimera (PK20) on inflammation in murine model of contact sensitivity reaction and non-atho...

Call: OPUS 7 , Panel: NZ7

Principal investigator: dr hab. Katarzyna Kaczyńska

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

Fentanyl opioid designer drugs: from molecular modeling to in vitro studies

Call: OPUS 6 , Panel: ST4

Principal investigator: prof. Joanna Sadlej

Narodowy Instytut Leków

The role of endogenous opioid system in the pathogenesis and treatment of inflammatory bowel diseases and colitis-associ...

Call: PRELUDIUM 6 , Panel: NZ7

Principal investigator: dr Marta Zielińska

Uniwersytet Medyczny w Łodzi, Wydział Lekarski

Synthesis and pharmacological characterization of novel cyclic opioid peptide analogs incorporating fluoro amino acids.

Call: PRELUDIUM 5 , Panel: NZ7

Principal investigator: dr Justyna Piekielna-Ciesielska

Uniwersytet Medyczny w Łodzi, Wydział Lekarski

Identification of the crucial metabolic pathways in the central nervous system in the patophysiology of opioid dependenc...

Call: OPUS 4 , Panel: NZ4

Principal investigator: dr hab. Piotr Suder

Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie, Wydział Inżynierii Materiałowej i Ceramiki

Neural mechanisms underlying pathology of motivation.

Call: SONATA BIS 2 , Panel: NZ3

Principal investigator: dr Jan Manuel Rodriguez-Parkitna

Instytut Farmakologii PAN

Examine the importance of intracellular pathways in the action of opioids in microglial cells in vitro

Call: PRELUDIUM 4 , Panel: NZ3

Principal investigator: Katarzyna Popiołek-Barczyk

Instytut Farmakologii PAN

Activation of endogenous pronociceptive mechanisms of opioid system as an important factors in the development of neurop...

Call: MAESTRO 3 , Panel: NZ4

Principal investigator: prof. Barbara Elżbieta Przewłocka

Instytut Farmakologii PAN

Investigation of neuroprotective potency and mechanism of action of opioid-neurotensin hybrid peptides in organotypic hi...

Call: PRELUDIUM 2 , Panel: NZ4

Principal investigator: dr Patrycja Magdalena Kleczkowska

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

Structure-activity relationship of bifunctional peptides, agonists of opioid receptors and antagonists of neurokinin rec...

Call: PRELUDIUM 2 , Panel: ST5

Principal investigator: Jolanta Dyniewicz

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

Synthesis of deltorphin I and dermorphin analogues modified with alfa-alkyl-beta-azido(amino)alanine in postion 2 or 3.

Call: PRELUDIUM 2 , Panel: ST5

Principal investigator: Anika Marta Lasota

Politechnika Łódzka, Politechnika Łódzka, Wydział Chemiczny,

Study of ligand binding and activation processes of formyl, opioid and cannabinoid G-protein-coupled receptors

Call: OPUS 2 , Panel: NZ1

Principal investigator: prof. Sławomir Hubert Filipek

Uniwersytet Warszawski, Wydział Chemii

Role of opioid receptors in arterial hypertension. Examination of hypotensive action of biphalin, a synthetic non-addtic...

Call: OPUS 2 , Panel: NZ4

Principal investigator: prof. Janusz Bogumił Sadowski

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

Opioid receptors in the basal ganglia of the brain as targets for alcohol abuse therapy.

Call: OPUS 2 , Panel: NZ4

Principal investigator: dr Jan Manuel Rodriguez Parkitna

Instytut Farmakologii PAN

Exploring new drug targets for efficacious therapy of neuropathic pain basing on the assessment and modulation of neuroi...

Call: OPUS 2 , Panel: NZ4

Principal investigator: dr hab. Joanna Gabriela Mika

Instytut Farmakologii PAN

The role of endogenous opioid peptides in the local regulation of prolactin secretion from the anterior pituitary in cyc...

Call: PRELUDIUM 1 , Panel: NZ9

Principal investigator: dr Kinga Tworus

Uniwersytet Warmińsko-Mazurski w Olsztynie, WYDZIAŁ BIOLOGII

Gene and protein analysis of OPRM1/MOR and OPRK1/KOR opioid receptors expression and neurobiological marker of nerve ter...

Call: PRELUDIUM 1 , Panel: NZ4

Principal investigator: Piotr Kazimierz Kupczyk

Instytut Immunologii i Terapii Doświadczalnej im. Ludwika Hirszfelda Polskiej Akademii Nauk

Correlation between experimental and theoretical NMR shielding parameters for order and disorder molecular crystals of s...

Call: PRELUDIUM 1 , Panel: ST4

Principal investigator: Tomasz Pawlak

Centrum Badań Molekularnych i Makromolekularnych PAN