Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

Delete all

The effect of Hmmr gene and its interaction with the endogenous opioid system as a novel mechanism and a therapeutic target for blood pressure regulation

2019/35/D/NZ5/02820

Keywords:

hypertension vascular function inflammation endogenous opioid system vascular remodelling

Descriptors:

  • NZ4_4: Pathophysiology
  • NZ5_7: Human disease treatment
  • NZ5_3: Pathogenesis of human diseases

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Instytut Genetyki i Biotechnologii Zwierząt Polskiej Akademii Nauk

woj.

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Dominik Stanisław Skiba 

Number of co-investigators in the project: 3

Call: SONATA 15 - announced on 2019-09-16

Amount awarded: 888 360 PLN

Project start date (Y-m-d): 2020-09-30

Project end date (Y-m-d): 2024-06-29

Project duration:: 45 months (the same as in the proposal)

Project status: Project completed

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (7)
  1. Cardiovascular Effects Mediated by HMMR and CD44
    Authors:
    Kinga Jaskuła, Mariusz Sacharczuk, Zbigniew Gaciong, Dominik S. Skiba
    Academic press:
    Mediators of Inflammation (rok: 2021, tom: 2021, strony: 45666), Wydawca: Hindawi
    Status:
    Published
    DOI:
    10.1155/2021/4977209 - link to the publication
  2. Hypertensive Effect of Downregulation of the Opioid System in Mouse Model of Different Activity of the Endogenous Opioid System
    Authors:
    Dominik S. Skiba, Piotr Szczepaniak, Mateusz Siedliński, Piotr Poznański, Marzena Łazarczyk, Kinga Jaskuła, Piotr Religa, Mariusz Sacharczuk, Zbigniew Gaciong
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, ), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22084179 - link to the publication
  3. Hypertensive Effect of Downregulation of the Opioid System in Mouse Model of Different Activity of the Endogenous Opioid System
    Authors:
    Dominik S. Skiba, Piotr Szczepaniak, Mateusz Siedliński, Piotr Poznański, Marzena Łazarczyk, Kinga Jaskuła, Piotr Religa, Mariusz Sacharczuk, Zbigniew Gaciong
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22, strony: 45669), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22084179 - link to the publication
  4. Cardiovascular Effects Mediated by HMMR and CD44
    Authors:
    Kinga Jaskuła, Mariusz Sacharczuk, Zbigniew Gaciong, Dominik S. Skiba
    Academic press:
    Mediators of Inflammation (rok: 2021, ), Wydawca: Hindawi
    Status:
    Published
    DOI:
    10.1155/2021/4977209 - link to the publication
  5. The Role of Opioid Receptor Antagonists in Regulation of Blood Pressure and T-Cell Activation in Mice Selected for High Analgesia Induced by Swim Stress
    Authors:
    Skiba Dominik, Kinga Jaskuła, Agata Nawrocka, Piotr Poznański, Marzena Łazarczyk, Łukasz Szymański, Tymoteusz Żera, Mariusz Sacharczuk, Agnieszka Cudnoch-Jędrzejewska, Zbigniew Gaciong
    Academic press:
    International Journal of Molecular Sciences (rok: 2024, tom: 25, strony: 45675), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms25052618 - link to the publication
  6. Cardiovascular Effects Mediated by HMMR and CD44
    Authors:
    Kinga Jaskuła, Mariusz Sacharczuk, Zbigniew Gaciong, Dominik S. Skiba
    Academic press:
    Mediators of Inflammation (rok: 2021, tom: 2021, strony: 45666), Wydawca: Hindawi
    Status:
    Published
    DOI:
    10.1155/2021/4977209 - link to the publication
  7. Hypertensive Effect of Downregulation of the Opioid System in Mouse Model of Different Activity of the Endogenous Opioid System
    Authors:
    Dominik S. Skiba, Piotr Szczepaniak, Mateusz Siedliński, Piotr Poznański, Marzena Łazarczyk, Kinga Jaskuła, Piotr Religa, Mariusz Sacharczuk, Zbigniew Gaciong
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22, strony: 45669), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22084179 - link to the publication

O Narodowym Centrum Nauki

Finansowanie nauki

Współpraca zagraniczna

Centrum prasowe

Deklaracja dostępności
Przetwarzanie danych osobowych
Polityka cookies

Partnerzy