Projects funded by the NCN

Novel covalent modulators of plasma kallikrein activity

Call: PRELUDIUM 24 , Panel: NZ7

Principal investigator: Jan Konopka

Uniwersytet Jagielloński

A new feature of the yeast Kazachstania humilis species: Growth-inhibitory properties against a broad spectrum of bacter...

Call: OPUS 28 , Panel: NZ9

Principal investigator: dr hab. Anna Sikora

Instytut Biochemii i Biofizyki PAN

Tick-borne encephalitis virus protease as a molecular target for novel inhibitors and activity-based probes

Call: OPUS 28 , Panel: NZ6

Principal investigator: dr Renata Grzywa

Politechnika Wrocławska

Controlling the covalent activity of a PD-L1 inhibitors with light

Call: PRELUDIUM 23 , Panel: NZ7

Principal investigator: Wiktor Jan Uzar

Uniwersytet Jagielloński

Designing Active Inhibitors of SARS-CoV-2 Methyltransferases

Call: PRELUDIUM 22 , Panel: NZ7

Principal investigator: Alex Jun Matsuda

Uniwersytet Jagielloński, Małopolskie Centrum Biotechnologii Uniwersytetu Jagiellońskiego

Development of a cell-based assay for screening of SARS-CoV-2 PLpro inhibitors

Call: SONATA 18 , Panel: NZ6

Principal investigator: dr Wioletta Katarzyna Rut

Politechnika Wrocławska

Effect of SSR 504734, a selective glycine transporter type 1 inhibitor, on seizure activity and therapeutic efficacy of ...

Call: OPUS 21 , Panel: NZ7

Principal investigator: prof. Piotr Wiktor Wlaź

Uniwersytet Marii Curie-Skłodowskiej w Lublinie, Wydział Biologii i Biotechnologii

Development of a three-dimensional in vitro model for studying the mechanisms of immunostimulatory activity of PD-1/PD-L...

Call: PRELUDIUM 18 , Panel: NZ5

Principal investigator: Justyna Natalia Kocik-Król

Uniwersytet Jagielloński, Wydział Chemii

NADPH oxidase genes expression in peripheral blood mononuclear cells (PBMC) in anti-TNF alpha-treated rheumatoid arthrit...

Call: PRELUDIUM 16 , Panel: NZ5

Principal investigator: Tomasz Stanisław Wysocki

Instytut Reumatologii im. prof. dr hab. med. Eleonory Reicher

Dual action mode inhibitors of urease and their anti-virulent activity against Helicobacter pylori and Cryptococcus neof...

Call: OPUS 16 , Panel: NZ6

Principal investigator: prof. Artur Jacek Mucha

Politechnika Wrocławska

Characterization of hydrolysates and peptides derived from oat kernels proteins in the context of their activity in dise...

Call: PRELUDIUM 16 , Panel: NZ9

Principal investigator: dr Monika Anna Pliszka

Uniwersytet Warmińsko-Mazurski w Olsztynie, Wydział Nauki o Żywności

Search for structure-antimicrobial activity correlation for selected boraheterocycles

Call: OPUS 16 , Panel: ST5

Principal investigator: prof. Sergiusz Mariusz Luliński

Politechnika Warszawska, Wydział Chemiczny

Proteins of dry-cured pork loins with the addition of a probiotic bacterial strain as a potential source od peptides wit...

Call: PRELUDIUM 15 , Panel: NZ9

Principal investigator: dr Paulina Maria Kęska

Uniwersytet Przyrodniczy w Lublinie, Wydział Nauk o Żywności i Biotechnologii

CP protease of the O'nyong-nyong virus: substrate profiling, design and synthesis of inhibitors and activity-based probe...

Call: OPUS 15 , Panel: NZ6

Principal investigator: dr hab. Marcin Sieńczyk

Politechnika Wrocławska

Novel human topoisomerase II inhibitors as anticancer agents

Call: PRELUDIUM 15 , Panel: NZ7

Principal investigator: dr Barbara Kaproń

Uniwersytet Medyczny w Lublinie, Wydział Nauk o Zdrowiu

Polymeric inhibitors of Zika virus

Call: OPUS 14 , Panel: ST5

Principal investigator: prof. Maria Nowakowska

Uniwersytet Jagielloński, Wydział Chemii

Anilide derivatives of long-chain cyclic amines as multifunctional serotonin receptors ligands and phosphodiesterase 7 i...

Call: PRELUDIUM 13 , Panel: NZ7

Principal investigator: dr Agnieszka Wioleta Jankowska

Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny

Optical and time-resolved spectroscopy for hypothesis veryfication of the conducting by mTS the reductive reaction with ...

Call: PRELUDIUM 13 , Panel: NZ1

Principal investigator: Małgorzata Katarzyna Prokopowicz

Uniwersytet Warszawski, Wydział Fizyki

Design of new small molecular regulators (inhibitors, activators) of the catalytic activity of adenylate kinases. Molecu...

Call: OPUS 13 , Panel: ST4

Principal investigator: dr Anna Kozakiewicz-Piekarz

Uniwersytet Mikołaja Kopernika, Wydział Chemii

Development of HTS method based on fluorescently labelled guanosine analogues: novel route for RNA (guanosine-N7)-methyl...

Call: PRELUDIUM 12 , Panel: ST4

Principal investigator: Renata Kasprzyk

Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

Insights into biological activity and mechanism of action of novel styrylquinazoline derivatives as tyrosine kinase inhi...

Call: PRELUDIUM 12 , Panel: NZ7

Principal investigator: Katarzyna Anna Malarz

UNIWERSYTET ŚLĄSKI, Wydział Matematyki, Fizyki i Chemii

Evaluation of anticancer activity of new pyridine derivatives perturbing mitotic spindle formation

Call: PRELUDIUM 12 , Panel: NZ7

Principal investigator: dr Magdalena Anna Perużyńska

Pomorski Uniwersytet Medyczny w Szczecinie, Wydział Lekarski z Oddziałem Nauczania w Języku Angielskim

Serum PAD-activity: Risk Factor in Development and Novel Biomarker in Rheumatoid Arthritis

Call: OPUS 12 , Panel: NZ5

Principal investigator: dr hab. Piotr Mateusz Mydel

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

Evaluation of SLC22A5 activity modulation in sensitizing glioma cells to the suppression of fatty acid oxidation by CPT1...

Call: PRELUDIUM 12 , Panel: NZ3

Principal investigator: Barbara Elżbieta Juraszek

Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

Novel multi-target directed ligands combining cholinesterase inhibition and 5-HT6 antagonism - design, synthesis and pha...

Call: SONATA 12 , Panel: NZ7

Principal investigator: dr hab. Anna Karolina Więckowska

Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny

New amide derivatives of cinnamic acid as a carbonyl reductase inhibitors, which modulate the activity of doxorubicin - ...

Call: SONATA 11 , Panel: NZ7

Principal investigator: dr Paulina Koczurkiewicz-Adamczyk

Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny

Analysis of the effectiveness of anticancer activity of tyrosine kinase inhibitors combined with nanoparticles in in vit...

Call: SONATA 11 , Panel: ST4

Principal investigator: dr Natalia Piergies

Instytut Fizyki Jądrowej im. Henryka Niewodniczańskiego PAN

Application of approximate non-empirical model based on long-range terms of interaction energy for assessment of inhibit...

Call: PRELUDIUM 11 , Panel: ST4

Principal investigator: Wiktoria Jedwabny (z d. Giedroyć-Piasecka)

Politechnika Wrocławska, Wydział Chemiczny

Anticancer activity of novel tubulin polymerization inhibitors obtained by the chemical modification of colchicine

Call: OPUS 11 , Panel: ST5

Principal investigator: dr hab. Adam Włodzimierz Huczyński

Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Chemii

New hydrids of tetrahydroacridine derivatives as a acetylocholinesterase with multifunctional activity

Call: OPUS 10 , Panel: NZ7

Principal investigator: prof. Paweł Bartosz Szymański

Uniwersytet Medyczny w Łodzi, Wydział Farmaceutyczny

Covalent inhibiors of bacterial ureases - design, activity and mode of binding

Call: PRELUDIUM 9 , Panel: NZ1

Principal investigator: dr Katarzyna Magdalena Macegoniuk

Politechnika Wrocławska, Wydział Chemiczny

Synthesis of fluorogenic substrates, inhibitors and activity-based probes of human neutrophil proteinase NSP4 and its ev...

Call: OPUS 8 , Panel: ST5

Principal investigator: prof. Adam Jerzy Lesner

Uniwersytet Gdański, Wydział Chemii

Functionalized amino acids - inibitors of GABA uptake with antianalgetic activity

Call: OPUS 8 , Panel: NZ7

Principal investigator: dr Paula Magdalena Zaręba

Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny

Design and synthesis of probes for RabGGTase profiling and their application for identification of the site of phosphono...

Call: SONATA BIS 4 , Panel: ST5

Principal investigator: dr hab. Katarzyna Błażewska

Politechnika Łódzka, Wydział Chemiczny

Multicommutated bioanalytical systems for kinetic studies and enzyme activity assays

Call: OPUS 7 , Panel: ST4

Principal investigator: prof. Robert Koncki

Uniwersytet Warszawski, Wydział Chemii

Evaluation of the immunomodulatory activity of cefazolin as a potential inhibitor of proinflammatory cytokines which bin...

Call: PRELUDIUM 7 , Panel: NZ7

Principal investigator: dr Barbara Joanna Żyżyńska-Granica

Warszawski Uniwersytet Medyczny, Wydział Nauki o Zdrowiu z Oddziałem Pielęgniarstwa, Oddziałem Zdrowia Publicznego i Oddziałem Dietetyki

Design, chemical synthesis and biological activity of inhibitors of matriptase-2.

Call: PRELUDIUM 7 , Panel: ST5

Principal investigator: Agata Elżbieta Gitlin-Domagalska

Uniwersytet Gdański, Wydział Chemii

Investigation of the molecular mechanisms of anti-leukemic activity of SK053, a small molecule compound targeting enzyme...

Call: SONATA BIS 3 , Panel: NZ5

Principal investigator: prof. Dominika Anna Nowis

Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

Effect of aliskiren, a renin inhibitor, on the anticonvulsant activity of antiepileptic drugs in three seizure tests in ...

Call: OPUS 5 , Panel: NZ7

Principal investigator: dr Krzysztof Łukawski

Instytut Medycyny Wsi im. Witolda Chodźki

Bioactive organoselenium compounds in self-organizing systems: design, synthesis and biological evaluation

Call: SONATA 5 , Panel: ST5

Principal investigator: dr Magdalena Piętka-Ottlik

Politechnika Wrocławska, Wydział Chemiczny

Aminopeptidases activity profiling in lysates of cell line HeLa using library of fluorogenic substrates

Call: PRELUDIUM 5 , Panel: NZ1

Principal investigator: dr Anna Daria Byzia

Politechnika Wrocławska, Wydział Chemiczny

Inhibition of activity tryptophan hydroxylase-1 - the new conception in the treatment of mineral and bone disorders in c...

Call: OPUS 5 , Panel: NZ7

Principal investigator: prof. Krystyna Pawlak

Uniwersytet Medyczny w Białymstoku, Wydział Farmaceutyczny z Oddziałem Medycyny Laboratoryjnej

Extracellular proteolytic activity of human epithelium - role in the modulation of signal transduction.

Call: SYMFONIA 1 , Panel: NZ1

Principal investigator: prof. Jan Stanislaw Potempa

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

Synthesis and preliminary studies on biological activity of glycosyltransferases natural substrates analogues, derivativ...

Call: PRELUDIUM 4 , Panel: ST5

Principal investigator: Roman Marcin Komor

Politechnika Śląska, Wydział Chemiczny

Synthesis and pharmacological properties of mono- di- and triheterocyclic azole derivatives as a hybrid receptor and PDE...

Call: OPUS 4 , Panel: NZ7

Principal investigator: prof. Maciej Henryk Pawłowski

Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny

Structure - activity relationship studies of new flavonoids derivatives as the inhibitors of the bacterial tyrosyl-tRNA ...

Call: PRELUDIUM 3 , Panel: NZ7

Principal investigator: dr Mirosława Anna Skupińska

Instytut Chemii Bioorganicznej PAN

Diaminophosphonates as specific inhibitors of Neisseria meningitidis aminopeptidase N - synthesis and biological activit...

Call: PRELUDIUM 3 , Panel: ST5

Principal investigator: Ewelina Marta Węglarz-Tomczak

Politechnika Wrocławska, Wydział Chemiczny

Evaluation of pharmacological activity of new, nonselective gamma-aminobutyric acid (GABA) transport inhibitors in some ...

Call: OPUS 3 , Panel: NZ7

Principal investigator: dr hab. Kinga Sałat

Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny

Modifications of aglycones of leucomycins via Michael addition and Huisgen dipolar cycloaddition as a new routes of synt...

Call: SONATA BIS 1 , Panel: ST5

Principal investigator: dr hab. Piotr Przybylski

Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Chemii

Design and synthesis of new rifampicin analogs as a source of effective bacterial RNA polymerase inhibitors

Call: OPUS 2 , Panel: ST5

Principal investigator: dr hab. Piotr Przybylski

Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Chemii