Projects funded by the NCN


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406 projects found matching your search criteria :

  1. Effects of tyrosine kinase inhibitors on Syk pathway in eNOS-based platelet subpopulations and on endothelial barrier in...

    Call: POLONEZ BIS 3 , Panel: NZ7

    Principal investigator: dr hab. Aneta Radziwon-Balicka

    Uniwersytet Jagielloński, Jagiellońskie Centrum Rozwoju Leków (JCET)

  2. Targeted inhibition of hypusination pathway

    Call: OPUS 24 , Panel: NZ7

    Principal investigator: dr Przemysław Grudnik

    Uniwersytet Jagielloński, Małopolskie Centrum Biotechnologii Uniwersytetu Jagiellońskiego

  3. Identification of key structural elements of immunomodulatory proteins - inhibitors of antigenic peptide transporter TAP...

    Call: SONATA 18 , Panel: NZ7

    Principal investigator: dr Natalia Karska

    Uniwersytet Gdański, Wydział Chemii

  4. The role of diet in the development of autoimmune diseases - new interleukin 15 inhibitors among dietary polyphenols and...

    Call: SONATA 18 , Panel: NZ9

    Principal investigator: dr Barbara Żyżyńska-Granica

    Warszawski Uniwersytet Medyczny

  5. Computational deciphering of pro-ferroptotic cell death protein machinery as a fundamental step in the search for therap...

    Call: SONATA BIS 12 , Panel: ST4

    Principal investigator: dr Karolina Mikulska-Rumińska

    Uniwersytet Mikołaja Kopernika w Toruniu, Wydział Fizyki, Astronomii i Informatyki Stosowanej

  6. Histone demethylase inhibitors as chemosensitivity modulators in the treatment of head and neck squamous cell carcinoma

    Call: PRELUDIUM 21 , Panel: NZ7

    Principal investigator: Dawid Dorna

    Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu

  7. Selective determination of isoenzymatic lactate dehydrogenase activity in flow analysis format

    Call: PRELUDIUM 21 , Panel: NZ5

    Principal investigator: Justyna Głowacka

    Uniwersytet Warszawski, Wydział Chemii

  8. Design, synthesis and in vitro and in vivo studies of anticancer potential of phosphonic and phosphinic analogs of sulfo...

    Call: OPUS 2 , Panel: ST5

    Principal investigator: prof. Tadeusz Gajda

    POLITECHNIKA ŁÓDZKA, Wydział Chemiczny

  9. Use of comparative oncology approach to dissect the PD-1 intrinsic signalling in osteosarcoma. Can dog be the key for ne...

    Call: PRELUDIUM 21 , Panel: NZ1

    Principal investigator: Katarzyna Dziubek

    Uniwersytet Gdański, Międzynarodowe Centrum Badań nad Szczepionkami Przeciwnowotworowymi

  10. Mechanisms and therapeutic potential of SGLT2/SGLT1 and NHE-1 inhibition in a rat model of heart failure with preserved ...

    Call: OPUS 23 , Panel: NZ5

    Principal investigator: dr hab. Urszula Mackiewicz

    Centrum Medyczne Kształcenia Podyplomowego

  11. Combination of FAAH inhibition with action via serotonin 5-HT6 receptor as pioneering approach to fight with Alzheimer D...

    Call: PRELUDIUM 21 , Panel: NZ7

    Principal investigator: Kinga Czarnota-Łydka

    Uniwersytet Jagielloński, Collegium Medicum

  12. Pharmacogenomics of SGLT2 inhibitors - investigating the role of empagliflozin in epigenetic modification of non-coding ...

    Call: PRELUDIUM 21 , Panel: NZ7

    Principal investigator: Anna Nowak

    Warszawski Uniwersytet Medyczny

  13. The effects of proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors on changes in selected epigenetic mechan...

    Call: PRELUDIUM 21 , Panel: NZ7

    Principal investigator: Agnieszka Woźniak

    Uniwersytet Medyczny w Łodzi, Wydział Lekarski

  14. Two-component preparations in the treatment of infections caused by pathogenic microorganisms

    Call: SONATA 17 , Panel: NZ7

    Principal investigator: dr Katarzyna Szałapata

    Uniwersytet Marii Curie-Skłodowskiej w Lublinie, Wydział Biologii i Biotechnologii

  15. Molecular determinants of input specificity in plasticity phenomena at GABAergic synapses in the hippocampus

    Call: OPUS 22 , Panel: NZ4

    Principal investigator: prof. Jerzy Mozrzymas

    Uniwersytet Medyczny im. Piastów Śląskich we Wrocławiu

  16. SELECTIVE REGULATION OF RAB GTPASES BY TARGETING PROTEIN-PROTEIN INTERACTIONS BETWEEN RABS AND REGULATORY PROTEINS

    Call: PRELUDIUM BIS 3 , Panel: ST4

    Principal investigator: dr hab. Katarzyna Błażewska

    Politechnika Łódzka, Wydział Chemiczny

  17. Combinatorial targeting of non-genetic sources of cell-to-cell heterogeneity to overcome fractional killing of cancer ce...

    Call: SONATA 17 , Panel: NZ3

    Principal investigator: dr Jarosław Walczak

    Instytut Podstawowych Problemów Techniki Polskiej Akademii Nauk

  18. Radiosensitization by the combined use of modified nucleosides and inhibitors of DNA repair to improve the efficacy of r...

    Call: SONATA 17 , Panel: ST4

    Principal investigator: dr Magdalena Zdrowowicz-Żamojć

    Uniwersytet Gdański, Wydział Chemii

  19. Structure-guided design of histone demethylase inhibitors for cancer therapy.

    Call: SONATA 17 , Panel: NZ7

    Principal investigator: dr Piotr Małecki

    Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

  20. Inhibition of protein disulfide isomerases as a strategy for reduction of prothrombotic state in atherosclerosis; therap...

    Call: SONATA 17 , Panel: NZ7

    Principal investigator: dr Kamil Przyborowski

    Uniwersytet Jagielloński, Jagiellońskie Centrum Rozwoju Leków (JCET)

  21. Small-molecule inhibitors of protein aggregation and ER stress as a novel strategy against neurodegeneration in the cour...

    Call: PRELUDIUM BIS 3 , Panel: NZ5

    Principal investigator: prof. Ireneusz Majsterek

    Uniwersytet Medyczny w Łodzi

  22. New strategies in the treatment of non-small cell lung cancer based on silk nanocarriers targeting tumor vascularization

    Call: SONATA 17 , Panel: NZ7

    Principal investigator: dr Anna Florczak

    Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu

  23. Function of DNA methylation and CNV-type polymorphisms of genes encoding metalloproteinase and their tissue inhibitors i...

    Call: OPUS 2 , Panel: NZ5

    Principal investigator: dr Edyta Majorczyk

    Politechnika Opolska, Wydział Wychowania Fizycznego i Fizjoterapii

  24. Targeting of HSF1 as a therapeutic approach to inhibit the progression of hormone-dependent breast cancer.

    Call: OPUS 22 , Panel: NZ5

    Principal investigator: dr Natalia Vydra

    Narodowy Instytut Onkologii im. Marii Skłodowskiej-Curie - Państwowy Instytut Badawczy, Oddział w Gliwicach

  25. Lipidic liquid-crystalline nanomaterials for reconstitution and physico-chemical studies of membrane proteins

    Call: OPUS 22 , Panel: ST4

    Principal investigator: prof. Renata Bilewicz

    Uniwersytet Warszawski, Wydział Chemii

  26. Inhibiting the Mitochondrial Intermembrane Space Assembly pathway as a newapproach to prevent metabolic reprogramming of...

    Call: OPUS 22 , Panel: NZ5

    Principal investigator: dr hab. Carlo Vascotto

    Instytut Hematologii i Transfuzjologii

  27. Search for Inhibitors of Human δ1-Pyrroline-5-Carboxylate Reductase 1 (PYCR1) as Lead Molecules for the Development of N...

    Call: OPUS 22 , Panel: NZ7

    Principal investigator: dr hab. Miłosz Ruszkowski

    Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

  28. Negative emotions: do they enhance or inhibit aggression in narcissism? The role of negative emotions in the regulation ...

    Call: SONATA 17 , Panel: HS6

    Principal investigator: dr Oliwia Maciantowicz

    Uniwersytet Warszawski, Wydział Psychologii

  29. The structures, biochemistry, physiology, and evolution of bacterial α2-macroglobulins from the human periodontopathogen...

    Call: SONATA BIS 11 , Panel: NZ1

    Principal investigator: dr Mirosław Książek

    Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

  30. RE-SENSE: Dual-loaded lipid nanoparticles to overcome the resistance of non-small cell lung cancer cells to personalized...

    Call: PRELUDIUM 20 , Panel: NZ7

    Principal investigator: Mikołaj Czajkowski

    Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu

  31. Metabolic stability and inhibition of P450 enzymes in combination with chemometric techniques as a tool for selection of...

    Call: OPUS 2 , Panel: NZ1

    Principal investigator: prof. Tomasz Bączek

    Gdański Uniwersytet Medyczny, Wydział Farmcautyczny z Oddziałem Medycyny Laboratoryjnej

  32. Research on the influence of medicines of the angiotensin-converting enzyme inhibitors (ACEI) group on the choroidal and...

    Call: PRELUDIUM 20 , Panel: NZ4

    Principal investigator: Jowita Zwolska

    Uniwersytet Przyrodniczy w Lublinie, Wydział Medycyny Weterynaryjnej

  33. Heterocyclization of benzenoid ansamycins core as useful strategy for designing anticancer agents

    Call: PRELUDIUM 20 , Panel: ST4

    Principal investigator: Natalia Skrzypczak

    Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Chemii

  34. Novel combination therapies of pulmonary arterial hypertension targeting blockade of peripheral cannabinoid CB1 receptor...

    Call: OPUS 21 , Panel: NZ7

    Principal investigator: prof. Barbara Malinowska

    Uniwersytet Medyczny w Białymstoku

  35. Pharmacological potential of mistletoe (Viscum album L.) in the prevention of central nervous system disorders.

    Call: PRELUDIUM 20 , Panel: NZ7

    Principal investigator: Anna Szurpnicka

    Narodowy Instytut Leków

  36. New type of analogs and conjugates of folic acid with potential therapeutic applicaton in treatment of hormone-dependent...

    Call: PRELUDIUM 20 , Panel: NZ7

    Principal investigator: Olga Ciupak

    Politechnika Gdańska, Wydział Chemiczny

  37. The role of glycosylation of structural proteins in the life cycle of SARS-CoV-2 coronavirus.

    Call: OPUS 21 , Panel: NZ6

    Principal investigator: dr hab. Ewelina Król

    Uniwersytet Gdański, Międzyuczelniany Wydział Biotechnologii Uniwersytetu Gdańskiego i Gdańskiego Uniwersytetu Medycznego

  38. Effect of SSR 504734, a selective glycine transporter type 1 inhibitor, on seizure activity and therapeutic efficacy of ...

    Call: OPUS 21 , Panel: NZ7

    Principal investigator: prof. Piotr Wlaź

    Uniwersytet Marii Curie-Skłodowskiej w Lublinie, Wydział Biologii i Biotechnologii

  39. The study of adsorption mechanisms of N-benzenamino(boronphenyl)methylphosphonic acids on different metal surfaces

    Call: PRELUDIUM 2 , Panel: ST4

    Principal investigator: dr Natalia Piergies

    Uniwersytet Jagielloński, Wydział Chemii

  40. An influence of lipoproteins on fibrinolysis and pleiotropic effect of proprotein convertase subtilisin/kexin type 9 (PC...

    Call: PRELUDIUM 20 , Panel: NZ5

    Principal investigator: Magdalena Kopytek

    Krakowski Szpital Specjalistyczny im. Jana Pawła II

  41. Antiviral strategies targeting RNA: Triplex forming peptide nucleic acids (PNA) and their small molecule conjugates spec...

    Call: OPUS 21 , Panel: NZ1

    Principal investigator: prof. Elżbieta Kierzek

    Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

  42. Blocking the TNF-TNFR2 interactions as a novel approach to the ovarian carcinoma treatment

    Call: OPUS 21 , Panel: NZ7

    Principal investigator: prof. Sylwia Rodziewicz-Motowidło

    Uniwersytet Gdański, Wydział Chemii

  43. Synthetic epidermal growth factor receptor inhibitor conjugated with nobel metal nanoparticles as a potential drug for t...

    Call: PRELUDIUM 20 , Panel: NZ7

    Principal investigator: Shaoshan Mai

    Gdański Uniwersytet Medyczny, Wydział Farmaceutyczny

  44. Verification of personalized therapeutic strategy based on Integrated Stress Response inhibition for myeloid neoplasms w...

    Call: OPUS 21 , Panel: NZ5

    Principal investigator: dr hab. Katarzyna Piwocka

    Instytut Biologii Doświadczalnej im. Marcelego Nenckiego Polskiej Akademii Nauk

  45. The SAR analysis and synthesis of complex, small molecule PD-1/PD-L1 interaction antagonists

    Call: PRELUDIUM 20 , Panel: ST4

    Principal investigator: Magdalena Żarnik

    Uniwersytet Jagielloński, Wydział Chemii

  46. Selective inhibitors of γ-aminobutyric acid (GABA) transporter subtype 3 (GAT3) as a new pharmacological tools and a cha...

    Call: OPUS 21 , Panel: NZ7

    Principal investigator: dr Dawid Panek

    Uniwersytet Jagielloński, Collegium Medicum

  47. Aging-associated, specific pathomechanisms of endothelial dysfunction in sepsis: pathway analysis and experimental thera...

    Call: WEAVE-UNISONO , Panel: NZ7

    Principal investigator: prof. Stefan Karol Chłopicki

    Uniwersytet Jagielloński

  48. Single cell multi-omics in defining how specific oncogenic alterations shape the immune microenvironment and responses t...

    Call: OPUS 20 , Panel: NZ4

    Principal investigator: prof. Bożena Kamińska-Kaczmarek

    Instytut Biologii Doświadczalnej im. Marcelego Nenckiego Polskiej Akademii Nauk

  49. Cell-to-cell transmission of SARS-CoV2 virus

    Call: PRELUDIUM BIS 2 , Panel: NZ6

    Principal investigator: prof. Krystyna Bieńkowska-Szewczyk

    Uniwersytet Gdański, Międzyuczelniany Wydział Biotechnologii Uniwersytetu Gdańskiego i Gdańskiego Uniwersytetu Medycznego

  50. Blocking HVEM/LIGHT interactions using peptides - an innovative approach to immunosuppression

    Call: PRELUDIUM BIS 2 , Panel: ST4

    Principal investigator: dr hab. Adam Sieradzan

    Uniwersytet Gdański, Wydział Chemii