Projects funded by the NCN

The JAK/STAT pathway as a molecular contributor to the development of endometriosis: therapeutic potential of JAK inhibi...

Call: PRELUDIUM 24 , Panel: NZ7

Principal investigator: Aleksander Radosław Rycerz

Uniwersytet Medyczny w Łodzi

Dual cell cycle blockade and immune checkpoint inhibition as a potential strategy of sequential anticancer therapy

Call: PRELUDIUM 24 , Panel: NZ7

Principal investigator: Alicja Stanisława Słota

Uniwersytet Jagielloński

Dynamic RNA structures including pseudoknots and G-quadruplexes of influenza type A virus RNAs as targets for designing ...

Call: SHENG 4 , Panel: NZ1

Principal investigator: prof. Elżbieta Beata Kierzek

Instytut Chemii Bioorganicznej PAN

Novel insights into inhibition of PD-L1/PD-1 immune checkpoint – discovery and optimization of covalent PD-L1 inhibitors...

Call: SONATA 20 , Panel: ST5

Principal investigator: dr Radosław Dariusz Kitel

Uniwersytet Jagielloński

Tick-borne encephalitis virus protease as a molecular target for novel inhibitors and activity-based probes

Call: OPUS 28 , Panel: NZ6

Principal investigator: dr Renata Grzywa

Politechnika Wrocławska

Where Inhibition is not Enough- Development of Innovative Compounds for Targeted Degradation of Extracellular and Membra...

Call: OPUS 28 (LAP) , Panel: NZ5

Principal investigator: dr Marcin Skoreński

Politechnika Wrocławska

Novel hybrid coatings with advanced antimicrobial properties for surface modification in atmospheric water harvesting sy...

Call: OPUS 27 , Panel: ST11

Principal investigator: prof. Anna Elżbieta Kowalewska

Centrum Badań Molekularnych i Makromolekularnych PAN

Frog skin derived cyclic peptide as a molecular scaffold to create a novel tool for combining visualization and inhibiti...

Call: PRELUDIUM 23 , Panel: ST5

Principal investigator: Aleksandra Dorota Helbik-Maciejewska

Uniwersytet Gdański

Small molecule modulators of the tumor necrosis factor alpha signaling pathway for the inhibition of inflammatory proces...

Call: OPUS 27 , Panel: NZ7

Principal investigator: prof. Tadeusz Holak

Uniwersytet Gdański

Interaction between temporal predictability and action control in ADHD and Parkinson's Disease: behavioural, neurophysio...

Call: SONATINA 8 , Panel: HS6

Principal investigator: dr Inga Justyna Korolczuk

Uniwersytet Medyczny w Lublinie

Selective inhibition of Janus kinases for the treatment of autoimmune hepatitis: Translational PK/PD modelling from mole...

Call: SONATA 19 , Panel: NZ7

Principal investigator: dr Artur Świerczek

Uniwersytet Jagielloński, Collegium Medicum

Restoring Beta-cell Integrity through Targeted SPOP Inhibition and PDX-1 Preservation

Call: OPUS 26 (LAP) , Panel: NZ7

Principal investigator: dr Anna Czarna

Uniwersytet Jagielloński, Małopolskie Centrum Biotechnologii Uniwersytetu Jagiellońskiego

Targeting adenylate kinase 4 (AK4) as a new paradigm in the treatment of non-small cell lung cancer: discovery and evalu...

Call: OPUS 26 , Panel: NZ7

Principal investigator: dr Magdalena Wujak

Uniwersytet Mikołaja Kopernika, Collegium Medicum im. Ludwika Rydygiera w Bydgoszczy

The inhibition of NMDAR and TRPM4 coupling - a hope for novel therapeutic target for the treatment of the ischemic brain...

Call: SONATA BIS 13 , Panel: NZ7

Principal investigator: dr Bartosz Sebastian Pomierny

Uniwersytet Jagielloński, Collegium Medicum

Physiological significance and clinical implications of global and local inhibition of NRF2 transcriptional activity in ...

Call: SONATA BIS 13 , Panel: NZ4

Principal investigator: dr hab. Aleksandra Barbara Piechota-Polańczyk

Uniwersytet Medyczny w Łodzi, Wydział Lekarski

Molecular mechanisms of DNA damage triggered by PIM kinases inhibition and its consequences for activation of innate imm...

Call: OPUS 25 , Panel: NZ5

Principal investigator: prof. Przemysław Juszczyński

Instytut Hematologii i Transfuzjologii

The effect of Tcf7l2 knockout on excitation/inhibition balance in neuronal circuits of the thalamus

Call: PRELUDIUM 22 , Panel: NZ3

Principal investigator: Katarzyna Aleksandra Hryniewiecka

Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

Targeted inhibition of hypusination pathway

Call: OPUS 24 , Panel: NZ7

Principal investigator: dr Przemysław Marek Grudnik

Uniwersytet Jagielloński, Małopolskie Centrum Biotechnologii Uniwersytetu Jagiellońskiego

Selective determination of isoenzymatic lactate dehydrogenase activity in flow analysis format

Call: PRELUDIUM 21 , Panel: NZ5

Principal investigator: Justyna Weronika Głowacka-Gudanek

Uniwersytet Warszawski, Wydział Chemii

Mechanisms and therapeutic potential of SGLT2/SGLT1 and NHE-1 inhibition in a rat model of heart failure with preserved ...

Call: OPUS 23 , Panel: NZ5

Principal investigator: dr hab. Urszula Mackiewicz

CENTRUM MEDYCZNE KSZTAŁCENIA PODYPLOMOWEGO

Combination of FAAH inhibition with action via serotonin 5-HT6 receptor as pioneering approach to fight with Alzheimer D...

Call: PRELUDIUM 21 , Panel: NZ7

Principal investigator: Kinga Maria Czarnota-Łydka

Uniwersytet Jagielloński, Collegium Medicum

Inhibition of protein disulfide isomerases as a strategy for reduction of prothrombotic state in atherosclerosis; therap...

Call: SONATA 17 , Panel: NZ7

Principal investigator: dr Kamil Przyborowski

Uniwersytet Jagielloński, Jagiellońskie Centrum Rozwoju Leków (JCET)

Novel combination therapies of pulmonary arterial hypertension targeting blockade of peripheral cannabinoid CB1 receptor...

Call: OPUS 21 , Panel: NZ7

Principal investigator: prof. Barbara Malinowska

Uniwersytet Medyczny w Białymstoku

Antiviral strategies targeting RNA: Triplex forming peptide nucleic acids (PNA) and their small molecule conjugates spec...

Call: OPUS 21 , Panel: NZ1

Principal investigator: prof. Elżbieta Beata Kierzek

Instytut Chemii Bioorganicznej PAN

Verification of personalized therapeutic strategy based on Integrated Stress Response inhibition for myeloid neoplasms w...

Call: OPUS 21 , Panel: NZ5

Principal investigator: dr hab. Katarzyna Piwocka

Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

The role of somatostatin- and parvalbumin interneurons in the modulation of neuronal function and synaptic plasticity vi...

Call: OPUS 20 , Panel: NZ4

Principal investigator: dr hab. Joanna Małgorzata Urban-Ciećko

Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

Novel dual CYP17A1 and AKR1C3 inhibitors for studying the mechanism of resistance in prostate cancer

Call: SONATA 16 , Panel: NZ7

Principal investigator: dr Tomasz Marcin Wróbel

Uniwersytet Medyczny w Lublinie

Anti-cancer strategy based on the induced G-quadruplex formation. Structural and biological properties of ligand-RNA/mRN...

Call: SONATA 16 , Panel: ST4

Principal investigator: dr Dorota Gudanis-Sobocińska

Instytut Chemii Bioorganicznej PAN

The influence of natural plant extracts obtained by supercritical extraction on the replication inhibition of the most i...

Call: OPUS 20 , Panel: NZ7

Principal investigator: prof. Grzegorz Jan Woźniakowski

Uniwersytet Mikołaja Kopernika

Input of the structure of influenza A virus RNA on regulation of virus proliferation. High throughput screening of small...

Call: OPUS 20 , Panel: NZ1

Principal investigator: prof. Elżbieta Beata Kierzek

Instytut Chemii Bioorganicznej PAN

The multifaceted nature of indecisiveness and its influence on cognitive control: A neurophysiological approach

Call: SONATA BIS 10 , Panel: HS6

Principal investigator: dr hab. Magdalena Senderecka

Uniwersytet Jagielloński, Wydział Filozoficzny

Ribozyme-based potential antibacterial strategy

Call: PRELUDIUM 19 , Panel: NZ1

Principal investigator: Joanna Miszkiewicz

Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

Foldback triplex-forming oligonucleotides as novel tools for G-quadruplex unfolding and selective inhibition of c-Myc on...

Call: OPUS 19 , Panel: NZ7

Principal investigator: prof. Anna Pasternak

Instytut Chemii Bioorganicznej PAN

Towards innovative strategy for treatment of Alzheimer's Disease via dual inhibition of receptor 5-HT6 and kinase CDK5.

Call: PRELUDIUM 19 , Panel: NZ7

Principal investigator: Sylwia Sudoł-Tałaj

Uniwersytet Jagielloński, Collegium Medicum

Behavioural and neuronal estimates of response inhibition in the face of conflict – a study of bilingual population

Call: ETIUDA 8 , Panel: HS6

Principal investigator: Patrycja Elżbieta Kałamała-Ligęza

Uniwersytet Jagielloński, Wydział Filozoficzny

Participation of cellular proteins in the inhibition of antigen presentation dependent on UL49.5 protein of bovine herpe...

Call: ETIUDA 8 , Panel: NZ3

Principal investigator: Magda Dominika Wąchalska

Uniwersytet Gdański, Międzyuczelniany Wydział Biotechnologii Uniwersytetu Gdańskiego i Gdańskiego Uniwersytetu Medycznego

Spectroscopic studies in micro- and nanoscale of the corrosion process and its inhibition of the modified metallic surfa...

Call: SONATA 15 , Panel: ST4

Principal investigator: dr Dominika Maria Święch

Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie, Wydział Odlewnictwa

Molecular mechanisms, signal transduction and inhibition of PEBP1-15LOX protein complex triggering the ferroptotic cell ...

Call: SONATA 15 , Panel: ST4

Principal investigator: dr hab. Karolina Anna Mikulska-Rumińska

Uniwersytet Mikołaja Kopernika, Wydział Fizyki, Astronomii i Informatyki Stosowanej

Sources of rationality: the role of inhibition and its neural substrate in decision strategy use

Call: OPUS 18 , Panel: HS6

Principal investigator: dr hab. Szymon Robert Wichary

Uniwersytet Jagielloński, Wydział Filozoficzny

Restoration of beta-cell function via inhibition of diabetic kinome.

Call: SONATA BIS 9 , Panel: NZ1

Principal investigator: dr Anna Czarna

Uniwersytet Jagielloński

The microRNA particles inhibiting expression of factors protecting from atherosclerotic plaque development in correlatio...

Call: PRELUDIUM 17 , Panel: NZ5

Principal investigator: Michał Krzysztof Kowara

Warszawski Uniwersytet Medyczny, Wydział Lekarski

Effects of proteasome inhibition on mitochondrial homeostasis.

Call: OPUS 17 , Panel: NZ5

Principal investigator: prof. Agnieszka Małgorzata Chacińska

Międzynarodowy Instytut Mechanizmów i Maszyn Molekularnych Polskiej Akademii Nauk

The assessment of cysteinyl leukotriene receptor antagonist role in inhibition of atherosclerosis, proliferation and its...

Call: OPUS 17 , Panel: NZ5

Principal investigator: dr hab. Paweł Maga

Uniwersytet Jagielloński, Collegium Medicum

Dietary polyphenols as thyroid peroxidase (TPO) modulators with multidirectional biological activity - a combined in vit...

Call: OPUS 17 , Panel: NZ9

Principal investigator: prof. Urszula Katarzyna Gawlik

Uniwersytet Przyrodniczy w Lublinie, Wydział Nauk o Żywności i Biotechnologii

Definition of targetable signaling pathways in chronic lymphocytic leukemia patients with rationale to novel therapy wit...

Call: PRELUDIUM 16 , Panel: NZ5

Principal investigator: Joanna Knap

Uniwersytet Medyczny w Lublinie, II Wydział Lekarski z Oddziałem Anglojęzycznym

Impact of Polycomb Complex PRC1 inhibition on autophagy process in endometrial and breast cancer cells

Call: PRELUDIUM 16 , Panel: NZ5

Principal investigator: Aleksandra Ewa Szustka

Uniwersytet Łódzki, Wydział Biologii i Ochrony Środowiska

The significance of cancer specific PFK-II (PFKFB3 and PFKFB4) isoenzymes inhibition in overcoming resistance to BRAF in...

Call: PRELUDIUM 16 , Panel: NZ5

Principal investigator: Sonia Elżbieta Trojan

Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum

Dissociating the effects of temporal predictability on differential types of impulse control in children

Call: PRELUDIUM 16 , Panel: HS6

Principal investigator: dr Inga Justyna Korolczuk

Uniwersytet Jagielloński, Wydział Filozoficzny

Inhibition of S-adenosyl-L-homocysteine hydrolase from Pseudomonas aeruginosa by targeting the enzyme dynamics

Call: SONATA BIS 8 , Panel: NZ1

Principal investigator: dr hab. Krzysztof Brzeziński

Instytut Chemii Bioorganicznej PAN

Extreme language control: activation and inhibition as bilingual control mechanisms in conference interpreting

Call: SONATA BIS 8 , Panel: HS2

Principal investigator: dr hab. Agnieszka Chmiel

Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Anglistyki