Projects funded by the NCN

Intestinal barrier dysfunction as a risk factor for pancreatic ductal adenocarcinoma: impact of fatty acid intake, with ...

Call: PRELUDIUM 24 , Panel: NZ4

Principal investigator: Wojciech Michał Jankowski

Uniwersytet Medyczny w Łodzi

Identifying early biomarkers and molecular targets for therapeutic intervention in right ventricular dysfunction

Call: OPUS 28 , Panel: NZ5

Principal investigator: prof. Przemysław Błyszczuk

Uniwersytet Jagielloński

A triple agonist of glucagon, GLP-1, and GIP receptors as a novel therapeutic option for the treatment of heart failure ...

Call: SONATA 20 , Panel: NZ5

Principal investigator: dr Marta Katarzyna Oknińska

CENTRUM MEDYCZNE KSZTAŁCENIA PODYPLOMOWEGO

4B for LDs: Biodiversity, Biogenesis, Biodegradation and Biomedicine of lipid droplets in age-dependent vascular dysfunc...

Call: SONATA BIS 14 , Panel: NZ7

Principal investigator: dr hab. Marta Zofia Pacia

Uniwersytet Jagielloński

Vascular dysfunction after breast cancer neoadjuvant chemotherapy.The significance of menopausal status and estrogens.

Call: SONATA 19 , Panel: NZ4

Principal investigator: dr Piotr Szczepaniak

Uniwersytet Jagielloński, Collegium Medicum

Alterations of branched-chain amino acids turnover and its supplementation in the prevention of cardiac dysfunction

Call: PRELUDIUM 22 , Panel: NZ4

Principal investigator: Agata Jędrzejewska

Gdański Uniwersytet Medyczny, Wydział Lekarski

The Role of the Mitochondrial Unfolded Protein Response (UPRmt) in Endothelial Function: a Possible Novel Target for the...

Call: PRELUDIUM 22 , Panel: NZ7

Principal investigator: Sylwester Tycjan Mosiołek

Uniwersytet Jagielloński, Jagiellońskie Centrum Rozwoju Leków (JCET)

Impact of uremic carbamylation on RAA system and endothelial dysfunction

Call: OPUS 24 , Panel: NZ4

Principal investigator: prof. Piotr Mydel

Uniwersytet Jagielloński

Dysfunction of NFE2L1 and other family members causes damage in dopaminergic neuron function through dysregulated transc...

Call: PRELUDIUM 21 , Panel: NZ5

Principal investigator: Kamila Łuczyńska

Instytut Genetyki i Hodowli Zwierząt PAN

Mechanisms and therapeutic potential of SGLT2/SGLT1 and NHE-1 inhibition in a rat model of heart failure with preserved ...

Call: OPUS 23 , Panel: NZ5

Principal investigator: dr hab. Urszula Mackiewicz

CENTRUM MEDYCZNE KSZTAŁCENIA PODYPLOMOWEGO

Mechanisms and consequences of small cerebral blod vessels dysfunction inexperimental hyponatremia in the presence of va...

Call: SONATA 17 , Panel: NZ4

Principal investigator: dr Marta Aleksandrowicz

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

In the search of specific oxylipin fingerprint reflecting the development of endothelial dysfunction with the use of non...

Call: SONATA 17 , Panel: NZ5

Principal investigator: dr Agnieszka Róża Kij

Uniwersytet Jagielloński, Jagiellońskie Centrum Rozwoju Leków (JCET)

Keap1-dependent proteopathy as a unifying mechanism of vascular dysfunction

Call: OPUS 22 , Panel: NZ4

Principal investigator: dr hab. Anna Maria Grochot-Przęczek

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

Role of unconventional myosin VI in development of cardiomyopathy: New insights into understanding of function and dysfu...

Call: PRELUDIUM BIS 3 , Panel: NZ5

Principal investigator: prof. Maria Jolanta Rędowicz

Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

Multilevel molecular analysis of the hepatoprotective effect of medicinal herbs extracts in prevention of liver dysfunct...

Call: OPUS 22 (LAP) , Panel: NZ9

Principal investigator: prof. Chandra Shekhar Pareek

Uniwersytet Mikołaja Kopernika, Wydział Nauk Biologicznych i Weterynaryjnych

Metabolic reprogramming in age-dependent endothelial dysfunction and vascular stiffness; novel mechanism of inflamm-agei...

Call: MAESTRO 13 , Panel: NZ4

Principal investigator: prof. Stefan Karol Chłopicki

Uniwersytet Jagielloński, Jagiellońskie Centrum Rozwoju Leków (JCET)

Proline metabolism as a novel therapeutic target for diseases associated with mitochondrial dysfunction.

Call: SONATA BIS 11 , Panel: NZ3

Principal investigator: dr Karolina Szczepanowska

Międzynarodowy Instytut Mechanizmów i Maszyn Molekularnych Polskiej Akademii Nauk

The role of ATP-dependent activation of P2 purinergic receptors in the energetic disturbances in the brain of autistic-l...

Call: PRELUDIUM 20 , Panel: NZ4

Principal investigator: Lidia Maria Babiec

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

Contribution of extracellular vesicles and exosomal arginase to immune dysfunction in endometriosis

Call: OPUS 21 , Panel: NZ6

Principal investigator: dr Małgorzata Maria Czystowska-Kuźmicz

Warszawski Uniwersytet Medyczny

Function and dysfunction of repeated tracts in non-coding and protein-coding transcripts

Call: OPUS 21 , Panel: NZ3

Principal investigator: dr hab. Agnieszka Fiszer

Instytut Chemii Bioorganicznej PAN

The role of lactate dehydrogenase A in development of endothelial dysfunction in murine model of heart failure

Call: PRELUDIUM 20 , Panel: NZ5

Principal investigator: Agnieszka Karolina Karaś

Uniwersytet Jagielloński, Jagiellońskie Centrum Rozwoju Leków (JCET)

Aging-associated, specific pathomechanisms of endothelial dysfunction in sepsis: pathway analysis and experimental thera...

Call: WEAVE-UNISONO , Panel: NZ7

Principal investigator: prof. Stefan Karol Chłopicki

Uniwersytet Jagielloński, Jagiellońskie Centrum Rozwoju Leków (JCET)

LDL-mimetic liposomal contrast agent for MRI-based detection of increased endothelial permeability in the early phase of...

Call: OPUS 20 , Panel: NZ5

Principal investigator: dr Anna Bar

Uniwersytet Jagielloński, Jagiellońskie Centrum Rozwoju Leków (JCET)

The mechanisms of mitochondrial damage-dependent neuroinflammation in experimental models of Parkinson's disease. The ro...

Call: OPUS 20 (LAP) , Panel: NZ4

Principal investigator: prof. Agata Adamczyk

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

The role of CD38 in the development of cardiovascular dysfunction

Call: PRELUDIUM 19 , Panel: NZ3

Principal investigator: Patrycja Maria Jabłońska

Gdański Uniwersytet Medyczny, Wydział Lekarski

Characteristics of neurodevelopmental and behavioral changes in the tsc2vu242 zebrafish model of Tuberous Sclerosis Comp...

Call: ETIUDA 8 , Panel: NZ3

Principal investigator: Magdalena Anna Senderowska

Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

Which patients with rheumatoid arthritis or axial spondyloarthritis without classical cardiovascular risk factors have m...

Call: PRELUDIUM 18 , Panel: NZ5

Principal investigator: Jarosław Łukasz Nowakowski

Uniwersytet Jagielloński, Collegium Medicum

Gamma-glutamylcysteine ligase participation in the antioxidant mechanism of action of sulodexide on vascular endothelial...

Call: PRELUDIUM 18 , Panel: NZ7

Principal investigator: Klaudia Katarzyna Bontor

Śląski Uniwersytet Medyczny w Katowicach, Wydział Nauk Medycznych w Katowicach

Function and phenotype of liver sinusoidal endothelial cells (LSECs) and their role in liver dysfunction development in ...

Call: PRELUDIUM 18 , Panel: NZ5

Principal investigator: Kamila Wojnar-Lasoń

Uniwersytet Jagielloński, Jagiellońskie Centrum Rozwoju Leków (JCET)

Improving quality of livers procured for transplantation from deceased donors using hypothermic machine perfusion

Call: SONATA BIS 9 , Panel: NZ5

Principal investigator: dr hab. Michał Jarosław Grąt

Warszawski Uniwersytet Medyczny

Comparative evaluation of effects of tyrosine kinase inhibitors (TKIs) on endothelial function in vivo in mice

Call: PRELUDIUM 17 , Panel: NZ5

Principal investigator: Brygida Elżbieta Marczyk

Uniwersytet Jagielloński, Jagiellońskie Centrum Rozwoju Leków (JCET)

The role of molecular composition of endothelial and pancreatic beta-cell extracellular vesicle in diabetic endothelial ...

Call: OPUS 17 , Panel: NZ3

Principal investigator: dr hab. Ewa Łucja Stępień

Uniwersytet Jagielloński

How dysfunction in the nuclear, RNA degrading enzyme DIS3 leads to mitotic defects creating a possible therapeutic strat...

Call: SONATINA 3 , Panel: NZ2

Principal investigator: dr Tomasz M. Kuliński

Międzynarodowy Instytut Biologii Molekularnej i Komórkowej

Immune-mediated dysfunction of vascular cells in abdominal aortic aneurysms.

Call: OPUS 16 , Panel: NZ5

Principal investigator: prof. Wojciech Szczeklik

Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum

Glycocalyx damage - the first stage of pathomechanism of endothelial dysfunction; measurements using capillary electroph...

Call: PRELUDIUM 16 , Panel: NZ7

Principal investigator: dr Karolina Martyna Matyjaszczyk-Gwarda

Uniwersytet Jagielloński, Jagiellońskie Centrum Rozwoju Leków (JCET)

Fibrosis or senescence- why transcriptionally inactivity of Nrf2 protects against colon dysfunction

Call: SONATA 14 , Panel: NZ4

Principal investigator: dr Aleksandra Barbara Piechota-Polańczyk

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

Role of angiotensin 1-12 and ACE-independent generation of Angiotensin II in peripheral endothelial dysfunction in heart...

Call: PRELUDIUM 15 , Panel: NZ4

Principal investigator: Tasnim Mohaissen

Uniwersytet Jagielloński, Jagiellońskie Centrum Rozwoju Leków (JCET)

Towards novel mechanisms of endothelial dysfunction in E3L.CETP mice displaying hyperlipidaemia with human-like lipoprot...

Call: OPUS 15 , Panel: NZ7

Principal investigator: prof. Stefan Karol Chłopicki

Uniwersytet Jagielloński, Jagiellońskie Centrum Rozwoju Leków (JCET)

Assessment of the usefulness of shear wave sonoelastography in the diagnosis and monitoring of the management of increas...

Call: PRELUDIUM 14 , Panel: NZ5

Principal investigator: Anna Olchowy

Uniwersytet Medyczny im. Piastów Śląskich we Wrocławiu, Wydział Farmaceutyczny z Oddziałem Analiutyki Medycznej, Wydział Lekarsko-Stomatologiczny

Molecular profile of exosomes present in bronchoalveolar lavage fluid as novel biomarker of immune dysfunction in non-sm...

Call: OPUS 14 , Panel: NZ6

Principal investigator: dr Małgorzata Maria Czystowska-Kuźmicz

Warszawski Uniwersytet Medyczny, I Wydział Lekarski

Dysfunction of pancreatic isles in type 2 diabetes – role of fatty acids and epigenetic mechanisms in maintenance of pan...

Call: PRELUDIUM 14 , Panel: NZ3

Principal investigator: Aneta Maria Dobosz

Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

How microglia-astrocyte interaction affects neuronal functioning in the dopaminergic system. Analysis of the protective ...

Call: OPUS 14 , Panel: NZ7

Principal investigator: dr Katarzyna Zofia Kuter

Instytut Farmakologii PAN

Regulation of vascular smooth muscle cells differentiation and plasticity in physiology and inflammation-induced vascula...

Call: SONATA 13 , Panel: NZ4

Principal investigator: dr Anna Filip

Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

The role of endoplasmic reticulum stress in the pathomechanisms of early-life stress-induced dysfunction of the prefrona...

Call: OPUS 13 , Panel: NZ7

Principal investigator: dr hab. Agnieszka Chocyk

Instytut Farmakologii PAN

Comparative effects of 1-methyl-1,2,3,4-tetrahydroisoquinoline (1MeTIQ) and olanzapine on the cognitive dysfunction meas...

Call: OPUS 13 , Panel: NZ7

Principal investigator: dr hab. Agnieszka Wąsik

Instytut Farmakologii PAN

Annexins as markers of vascular endothelium dysfunction in insulin resistance induced in vitro

Call: OPUS 12 , Panel: NZ3

Principal investigator: dr hab. Joanna Bandorowicz-Pikuła

Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

Involvement of P2 receptors in pathogenesis of glomerular filtration barrier dysfunction in experimental model of diabet...

Call: OPUS 12 , Panel: NZ5

Principal investigator: prof. Maciej Wojciech Jankowski

Gdański Uniwersytet Medyczny, Wydział Farmaceutyczny

Involvement of stearoyl-CoA desaturase-dependent signaling in pericardial and pericoronary adipose tissue and coronary a...

Call: SONATA BIS 6 , Panel: NZ4

Principal investigator: prof. Paweł Dobrzyń

Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

Participation of oxidized low density lipoprotein (oxLDL) in pathogenesis of glomerular filtration barrier dysfunction i...

Call: PRELUDIUM 11 , Panel: NZ4

Principal investigator: Kamil Wojciech Dąbkowski

Gdański Uniwersytet Medyczny, Wydział Farmaceutyczny

Role of epigenetic regulation mediated by microRNA in endothelial dysfunction.

Call: PRELUDIUM 11 , Panel: NZ2

Principal investigator: Sabina Magdalena Lichołai

Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Lekarski