Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Fibrosis or senescence- why transcriptionally inactivity of Nrf2 protects against colon dysfunction

2018/31/D/NZ4/00077

Keywords:

inflammatory bowel diseases Nrf2 fibrosis senescence

Descriptors:

  • NZ4_2: Physiology
  • NZ5_3: Pathogenesis of human diseases
  • NZ4_4: Pathophysiology

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Aleksandra Piechota-Polańczyk 

Number of co-investigators in the project: 3

Call: SONATA 14 - announced on 2018-09-14

Amount awarded: 1 065 694 PLN

Project start date (Y-m-d): 2019-11-29

Project end date (Y-m-d): 2023-09-28

Project duration:: 36 months (the same as in the proposal)

Project status: Project completed

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (6)
  1. The Nrf2 in the pathophysiology of the intestine: Molecular mechanisms and therapeutic implications for inflammatory bowel diseases
    Authors:
    Marta Piotrowska, Mikolaj Swierczynski, Jakub Fichna, Aleksandra Piechota-Polanczyk
    Academic press:
    Pharmacological research (rok: 2020, tom: 163, strony: 105243), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.phrs.2020.105243 - link to the publication
  2. Nrf2 Transcriptional Activity Governs Intestine Development
    Authors:
    Aleksandra Kopacz, Damian Kloska, Dominika Klimczyk, Magdalena Kopec, Alicja Jozkowicz and Aleksandra Piechota‐Polanczyk
    Academic press:
    International Journal of Molecular Sciences (rok: 2022, tom: 23, strony: 6175), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms23116175 - link to the publication
  3. The lack of transcriptionally active Nrf2 triggers colon dysfunction in female mice – The role of estrogens
    Authors:
    Aleksandra Kopacz, Damian Kloska, Jakub Fichna, Dominika Klimczyk, Magdalena Kopec, Alicja Jozkowicz, Aleksandra Piechota-Polanczyk
    Academic press:
    Free Radical Biology and Medicine (rok: 2022, tom: 192, strony: 141-151), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.freeradbiomed.2022.09.014 - link to the publication
  4. Overlooked and valuable facts to know in the NRF2/KEAP1 field
    Authors:
    Aleksandra Kopacz, Ana I. Rojo, Chinmai Patibandla, Diego Lastra-Martínez, Aleksandra Piechota-Polanczyk, Damian Kloska, Alicja Jozkowicz, Calum Sutherland, Antonio Cuadrado, Anna Grochot-Przeczek
    Academic press:
    Free Radical Biology and Medicine (rok: 2022, tom: 192, strony: 38-49), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.freeradbiomed.2022.08.044 - link to the publication
  5. Nrf2 transcriptional activity in the mouse affects the physiological response to tribromoethanol
    Authors:
    Aleksandra Kopacz, Ewa Werner, Damian Kloska, Sylwia Nesterak, Karolina Hajduk, Jakub Fichna, Alicja Jozkowicz, Aleksandra Piechota-Polanczyk
    Academic press:
    Biomedicine & Pharmacotherapy (rok: 2020, tom: 128, strony: 110317), Wydawca: Science Direct
    Status:
    Published
    DOI:
    10.1016/j.biopha.2020.110317 - link to the publication
  6. Simvastatin Attenuates Abdominal Aortic Aneurysm Formation Favoured by Lack of Nrf2 Transcriptional Activity
    Authors:
    Aleksandra Kopacz, Ewa Werner, Anna Grochot-Przęczek, Damian Klóska, Karolina Hajduk, Christoph Neumayer, Alicja Józkowicz, Aleksandra Piechota-Polanczyk
    Academic press:
    Oxidative Medicine and Cellular Longevity (rok: 2020, tom: 2020, strony: 2020: 6340190), Wydawca: Hindawi
    Status:
    Published
    DOI:
    10.1155/2020/6340190 - link to the publication

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