Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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The mechanisms of mitochondrial damage-dependent neuroinflammation in experimental models of Parkinson's disease. The role of Parkin dysfunction

2020/39/I/NZ4/01031

Keywords:

alpha-synuclein parkin mitochondrial damage neuroinflammation Parkinson's disease

Descriptors:

  • NZ4_11: Metabolism
  • NZ4_9: Systems neurobiology
  • NZ3_5: Molecular neurobiology

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego Polskiej Akademii Nauk

woj.

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Agata Adamczyk 

Number of co-investigators in the project: 9

Call: OPUS 20 (LAP) - announced on 2020-09-15

Amount awarded: 1 792 094 PLN

Project start date (Y-m-d): 2021-12-16

Project end date (Y-m-d): 2025-12-15

Project duration:: 48 months (the same as in the proposal)

Project status: Pending project

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (4)
  • Articles in post-conference publications (4)
  1. Glia-Neurotrophic Factor Relationships: Possible Role in Pathobiology of Neuroinflammation-Related Brain Disorders
    Authors:
    Ewelina Palasz, Anna Wilkaniec, Luiza Stanaszek, Anna Andrzejewska, Agata Adamczyk
    Academic press:
    International Journal of Molecular Sciences (rok: 2023, tom: 24, strony: 6321), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms24076321 - link to the publication
  2. Novel Insights into Parkin-Mediated Mitochondrial Dysfunction and "Mito-Inflammation" in α-Synuclein Toxicity. The Role of the cGAS-STING Signalling Pathway.
    Authors:
    Magdalena Gąssowska-Dobrowolska, Gabriela Olech-Kochańczyk, Carsten Culmsee, Agata Adamczyk
    Academic press:
    Journal of Inflammation Research (rok: 2024, tom: 17, strony: 4549-4574), Wydawca: Dove Medical Press
    Status:
    Published
    DOI:
    10.2147/JIR.S468609 - link to the publication
  3. Glia-Neurotrophic Factor Relationships: Possible Role in Pathobiology of Neuroinflammation-Related Brain Disorders
    Authors:
    Ewelina Palasz, Anna Wilkaniec, Luiza Stanaszek, Anna Andrzejewska, Agata Adamczyk
    Academic press:
    International Journal of Molecular Sciences (rok: 2023, tom: 24, strony: 6321), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms24076321 - link to the publication
  4. Liquid-liquid phase separation and conformational strains of α-Synuclein: implications for Parkinson's disease pathogenesis
    Authors:
    Eva D Ruiz-Ortega , Anna Wilkaniec , Agata Adamczyk
    Academic press:
    Frontiers in Molecular Neuroscience (rok: 2024, tom: 17, strony: 45674), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fnmol.2024.1494218 - link to the publication
  1. alpha-Synuclein, parkin and mitochondria dysfunction: a deleterious trio in Parkinson's disease pathogenesis.
    Authors:
    Anna Wilkaniec, Eva D. Ruiz Ortega, Agata Adamczyk
    Conference:
    Folia Neuropathologica 2022,60/Special Issue,p.8. (rok: 2022, tom: Molecular Basis of Pathology and Therapy in Neurological Disorders, strony: 8), Wydawca: Termedia Publishing House Ltd.
    Data:
    konferencja 20-22.10.2022
    Status:
    Published
    DOI:
    10.5114/fn.2022.121852 - link to the publication
  2. alpha-Synuclein, parkin and mitochondria dysfunction: a deleterious trio in Parkinson's disease pathogenesis.
    Authors:
    Anna Wilkaniec, Eva D. Ruiz Ortega, Agata Adamczyk
    Conference:
    Folia Neuropathologica 2022,60/Special Issue,p.8. (rok: 2022, tom: Molecular Basis of Pathology and Therapy in Neurological Disorders, strony: 8), Wydawca: Termedia Publishing House Ltd.
    Data:
    konferencja 20-22.10.2022
    Status:
    Published
    DOI:
    10.5114/fn.2022.121852 - link to the publication
  3. Linking neuroinflammation and neurodegeneration in an α-synuclein seeding/ spreading mouse model of Parkinson's disease
    Authors:
    Wilkaniec A., Czapski G., Gawinek E., Olech-Kochanczyk G., Babiec L., Cieslik M., Ruiz-Ortega E, Adamczyk A.
    Conference:
    Folia Neuropathologica 4/2024, vol. 62 (rok: 2025, tom: The 16th International Symposium MOLECULAR BASIS OF PATHOLOGY AND THERAPY IN NEUROLOGICAL DISORDERS, strony: 484), Wydawca: Termedia Publishing House Ltd.
    Data:
    konferencja 17-18 października, 2024
    Status:
    Published
    DOI:
    10.5114/fn.2024.147358 - link to the publication
  4. alpha-Synuclein, parkin and mitochondria dysfunction: a deleterious trio in Parkinson's disease pathogenesis.
    Authors:
    Anna Wilkaniec, Eva D. Ruiz Ortega, Agata Adamczyk
    Conference:
    Folia Neuropathologica 2022,60/Special Issue,p.8. (rok: 2022, tom: Molecular Basis of Pathology and Therapy in Neurological Disorders, strony: 8), Wydawca: Termedia Publishing House Ltd.
    Data:
    konferencja 20-22.10.2022
    Status:
    Published
    DOI:
    10.5114/fn.2022.121852 - link to the publication

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