Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Towards novel mechanisms of endothelial dysfunction in E3L.CETP mice displaying hyperlipidaemia with human-like lipoprotein profile

2018/29/B/NZ7/01684

Keywords:

endothelial dysfunction hyperlipidaemia endothelial profiling E3L.CETP mice

Descriptors:

  • NZ7_14:
  • NZ4_4:
  • NZ3_2:

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Jagielloński, Jagiellońskie Centrum Rozwoju Leków (JCET)

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Stefan Karol Chłopicki 

Number of co-investigators in the project: 5

Call: OPUS 15 - announced on 2018-03-15

Amount awarded: 1 887 200 PLN

Project start date (Y-m-d): 2019-02-04

Project end date (Y-m-d): 2022-12-03

Project duration:: 36 months (the same as in the proposal)

Project status: Project completed

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (9)
  1. Phylloquinone improves endothelial function, inhibits cellular senescence, and vascular infammation
    Authors:
    Anna Kierońska‑Rudek, Agnieszka Kij, Anna Bar, Anna Kurpińska, Tasnim Mohaissen, Marek Grosicki, Marta Stojak, Magdalena Sternak, Elżbieta Buczek, Bartosz Proniewski, Kamil Kuś, Joanna Suraj‑Prazmowska, Agnieszka Panek, Monika Pietrowska, Szczepan Zapotoczny, Catherine M. Shanahan, Csaba Szabo, Stefan Chłopicki
    Academic press:
    GeroScience (rok: 2024, tom: 46, strony: 4909–4935), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s11357-024-01225-w - link to the publication
  2. Direct comparison of inorganic nitrite and nitrate on vascular dysfunction and oxidative damage in experimental arterial hypertension
    Authors:
    Paul Stamm, Matthias Oelze, Sebastian Steven, Swenja Kroller-Schon, Miroslava Kvandova, Sanela Kalinovic, Agnieszka Jasztal, Agnieszka Kij, Marin Kuntic, Maria Teresa Bayo Jimenez, Bartosz Proniewski, Huige Li, Eberhard Schulz, Stefan Chlopicki, Andreas Daiber, Thomas Münzel
    Academic press:
    NITRIC OXIDE-BIOLOGY AND CHEMISTRY (rok: 2021, tom: 113, strony: 57-69), Wydawca: Elsevier Inc.
    Status:
    Published
    DOI:
    10.1016/j.niox.2021.06.001 - link to the publication
  3. Multi‑omic signatures of atherogenic dyslipidaemia: pre‑clinical target identification and validation in humans
    Authors:
    Mariola Olkowicz, Izabela Czyzynska‑Cichon, Natalia Szupryczynska, Renata B. Kostogrys, Zdzislaw Kochan, Janusz Debski, Michal Dadlez, Stefan Chlopicki and Ryszard T. Smolenski
    Academic press:
    Journal of Translational Medicine (rok: 2021, tom: 19, strony: nd.), Wydawca: BMC
    Status:
    Published
    DOI:
    10.1186/s12967-020-02663-8 - link to the publication
  4. In Vivo Magnetic Resonance Imaging-Based Detection of Heterogeneous Endothelial Response in Thoracic and Abdominal Aorta to Short-Term High-Fat Diet Ascribed to Differences in Perivascular Adipose Tissue in Mice
    Authors:
    Bar A, Kieronska-Rudek A, Proniewskia B, Suraj-Prażmowska J, Czamara K, Marczyk B, Matyjaszczyk-Gwarda K, Jasztal A, Kuś E, Majka Z, Kaczor A , Kurpińska A, Walczak M, Pieterman E, Princen HMG, Chlopicki S.
    Academic press:
    Journal of the American Heart Association (rok: 2020, tom: 9, strony: 46039), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1161/JAHA.120.016929 - link to the publication
  5. Revisiting pharmacology of oxidative stress and endothelial dysfunction in cardiovascular disease: Evidence for redox-based therapies
    Authors:
    Daiber A, Chlopicki S.
    Academic press:
    Free Radical Biology and Medicine (rok: 2020, tom: 157, strony: 15-37), Wydawca: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.freeradbiomed.2020.02.026 - link to the publication
  6. Exogenous Vitamins K Exert Anti-Inflammatory Effects Dissociated from Their Role as Substrates for Synthesis of Endogenous MK-4 in Murine Macrophages Cell Line
    Authors:
    Anna Kieronska-Rudek, Agnieszka Kij, Patrycja Kaczara, Anna Tworzydlo, Marek Napiorkowski, Katarzyna Sidoryk and Stefan Chlopicki
    Academic press:
    CELLS (rok: 2021, tom: 10, strony: nd.), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells10071571 - link to the publication
  7. Vitamin K2-MK-7 improves nitric oxide-dependent endothelial function in ApoE/LDLR−/− mice
    Authors:
    Anna Bar, Kamil Kus, Angelika Manterys, Bartosz Proniewski, Magdalena Sternak, Kamil Przyborowski, Martijn Moorlagd, Barbara Sitek, Brygida Marczyk, Agnieszka Jasztal, Tomasz Skórka, Magdalena Franczyk-Żarów, Renata B. Kostogrys, Stefan Chlopicki
    Academic press:
    Vascular Pharmacology (rok: 2019, tom: 122-123, strony: 46035), Wydawca: Elsevier Inc
    Status:
    Published
    DOI:
    10.1016/j.vph.2019.106581 - link to the publication
  8. Low phylloquinone intake deteriorates endothelial function in normolipidemic and dyslipidaemic mice
    Authors:
    Agnieszka Kij , Anna Kieronska-Rudek , Anna Bar , Izabela Czyzynska-Cichon , Magdalena Strus , Lucja Kozien , Grażyna Wiecek , Natalia Zeber-Lubecka , Maria Kulecka , Grzegorz Kwiatkowski , Kamil Przyborowski , Tasnim Mohaissen , Magdalena Sternak , Elżbieta Buczek , Agnieszka Zakrzewska , Bartosz Proniewski , Kamil Kuś , Magdalena Franczyk-Żarow , Renata B. Kostogrys , Elsbeth J. Pieterman , Hans M.G. Princen , Stefan Chłopicki
    Academic press:
    The Journal of Nutritional Biochemistry (rok: 2025, tom: b.d., strony: b.d.), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jnutbio.2025.109867 - link to the publication
  9. Rapid Replenishment of Phylloquinone in the Plasma and Liver Using Hyaluronan-Based Nanocapsules Reverses Endothelial Dysfunction in Mice
    Authors:
    Anna Kieronska-Rudek, Agnieszka Kij, Anna Bar, Magdalena Sternak, Aleksandra Paterek, Filip Rolski, Izabela Czyzynska-Cichon, Filip A Fedak, Kamila Wojnar-Lason, Justyna Bednorz, Małgorzata Janik-Hazuka, Renata B Kostogrys, Magdalena Franczyk-Zarow, Katarzyna Z Czyżowska, Lenka Michalkova, Michał Mączewski, Szczepan Zapotoczny, Edyta Kus, Stefan Chlopicki
    Academic press:
    Nanotechnology, Science and Applications (rok: 2025, tom: 18, strony: 245-262), Wydawca: Dovepress Taylor & Francis Group
    Status:
    Published
    DOI:
    10.2147/NSA.S520030 - link to the publication

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