Projects funded by the NCN

Dual-Target Compounds Modulating EAAT2 and Kv7.2/3 Channels: A Rational Strategy Toward Novel Antiseizure and Antinocice...

Call: OPUS 29 , Panel: NZ7

Principal investigator: dr Michał Andrzej Abram

Uniwersytet Jagielloński

Investigation of the mechanism of enhanced liposome delivery to tumors and its application for dual target immunotherapy

Call: OPUS 28 , Panel: NZ7

Principal investigator: dr hab. Tomasz Piotr Rygiel

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

Disruption of the posttranslational activation of the translation factor EF-P as a new target for antimicrobial agents.

Call: OPUS 27 , Panel: NZ7

Principal investigator: dr Piotr Wilk

Uniwersytet Jagielloński

Directed screening and evaluation of novel bactericidal compounds active againsttubercle bacilli and Mycobacterium absce...

Call: OPUS 25 , Panel: NZ7

Principal investigator: prof. Jarosław Dziadek

Instytut Biologii Medycznej PAN

Cuproptosis, a novel pathway of regulated cell death as a therapeutic target in treatment-naïve and targeted therapy-res...

Call: OPUS 25 , Panel: NZ5

Principal investigator: dr hab. Mariusz Łukasz Hartman

Uniwersytet Medyczny w Łodzi, Wydział Lekarski

Conjugates of peptide nucleic acids with aminoglycosides and fluoroquinolones as a novel strategy to target multi-drug r...

Call: PRELUDIUM 22 , Panel: ST5

Principal investigator: Izabela Siekierska

Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

Senolytic nanoplatform to target and eliminate skin cancer Zombie cells

Call: M-ERA.NET 2022 , Panel: ST5

Principal investigator: dr hab. Anna Karolina Lewińska

Uniwersytet Rzeszowski, Kolegium Nauk Przyrodniczych

Computational deciphering of pro-ferroptotic cell death protein machinery as a fundamental step in the search for therap...

Call: SONATA BIS 12 , Panel: ST4

Principal investigator: dr hab. Karolina Anna Mikulska-Rumińska

Uniwersytet Mikołaja Kopernika, Wydział Fizyki, Astronomii i Informatyki Stosowanej

Novel broad-spectrum central nervous system active substances: optimization of their multi-target profile

Call: OPUS 22 , Panel: NZ7

Principal investigator: dr hab. Agnieszka Anna Kaczor

Uniwersytet Medyczny w Lublinie, Wydział Farmaceutyczny

In search for molecular targets to overcome doxorubicin resistance in triple-negative breast cancer with the use of inno...

Call: PRELUDIUM 20 , Panel: NZ7

Principal investigator: Anna Karolina Pogorzelska

Narodowy Instytut Leków

The study on the molecular mechanisms of cytotoxic activity of new compounds ZOT5-1-Me and ZOT5-1-Et in an experimental ...

Call: SONATA 16 , Panel: NZ7

Principal investigator: dr Paulina Anna Tokarz

Uniwersytet Łódzki, Wydział Biologii i Ochrony Środowiska

Drug repurposing to target p53 protein family for improved therapy in the relapsed TP53 and EGFR mutated lung cancer

Call: OPUS 20 , Panel: NZ7

Principal investigator: dr Joanna Elżbieta Zawacka-Pankau

Warszawski Uniwersytet Medyczny

New multifunctional drug-like ligands focusing on molecular targets associated with the symptoms and causes of Alzheimer...

Call: PRELUDIUM 19 , Panel: NZ7

Principal investigator: Anna Marta Pasieka

Uniwersytet Jagielloński, Collegium Medicum

Novel L-asparaginases as potential therapeutic agents and antimicrobial targets: structural and functional studies of en...

Call: OPUS 19 , Panel: NZ1

Principal investigator: prof. Mariusz Jaskólski

Instytut Chemii Bioorganicznej PAN

Novel approach in the search for asthma and COPD therapies - computer aided design of multi-target-directed ligands bloc...

Call: PRELUDIUM 19 , Panel: NZ7

Principal investigator: Alicja Aleksandra Gawalska

Uniwersytet Jagielloński, Collegium Medicum

Gankyrin protein as a new potential therapeutic target in multiple myeloma

Call: OPUS 18 , Panel: NZ5

Principal investigator: dr hab. Irena Misiewicz-Krzemińska

Instytut Hematologii i Transfuzjologii

The enzymes of RNA metabolism, PAP I and PNPase, as targets for new antimycobacterial drugs and their functional charact...

Call: OPUS 13 , Panel: NZ7

Principal investigator: prof. Jarosław Dziadek

Instytut Biologii Medycznej PAN

Determination of arginase-1 as a potential drug target in the treatment of multiple myeloma and in reducing proteasome i...

Call: OPUS 13 , Panel: NZ6

Principal investigator: prof. Jakub Adam Gołąb

Warszawski Uniwersytet Medyczny, Wydział Lekarski

Identification of Mycobacterium tuberculosis ligands binding human serum amyloid A (SAA) and biological function of tube...

Call: OPUS 12 , Panel: NZ7

Principal investigator: dr hab. Bożena Renata Dziadek

Uniwersytet Łódzki, Wydział Biologii i Ochrony Środowiska

Novel multi-target directed ligands combining cholinesterase inhibition and 5-HT6 antagonism - design, synthesis and pha...

Call: SONATA 12 , Panel: NZ7

Principal investigator: dr hab. Anna Karolina Więckowska

Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny

Structural studies of signaling receptors HVEM/CD160 as potential targets for immunoterapy against melanoma

Call: SONATA 11 , Panel: NZ1

Principal investigator: dr Marta Orlikowska

Uniwersytet Gdański, Wydział Chemii

INNOvative antiSEPTic agents for a therapy with a broad spectrum of action

Call: OPUS 10 , Panel: NZ7

Principal investigator: dr Sebastian Kraszewski

Politechnika Wrocławska

A coarse-grained model of protein - nanoparticles interactions for simulating the transport of drug molecules to their t...

Call: PRELUDIUM 9 , Panel: ST4

Principal investigator: dr Magdalena Anna Mozolewska

Uniwersytet Gdański, Wydział Chemii

Simultaneous stimulation of muscarinic M4 receptor and selected receptors involved in the regulation of glutamate releas...

Call: OPUS 9 , Panel: NZ7

Principal investigator: dr hab. Joanna Monika Wierońska

Instytut Farmakologii PAN

Characteristics of the cell wall hydrolases of pathogenic bacteria Listeria monocytogenes and their partcipation in the ...

Call: OPUS 5 , Panel: NZ6

Principal investigator: dr hab. Magdalena Anna Popowska

Uniwersytet Warszawski, Wydział Biologii

Multitasking polymeric lattices included selected DNA oligonucleotide sequences - synthesis, modifications and physioche...

Call: SONATA 3 , Panel: ST5

Principal investigator: dr Ewelina Zabost

Uniwersytet Warszawski, Wydział Chemii

Exploring new drug targets for efficacious therapy of neuropathic pain basing on the assessment and modulation of neuroi...

Call: OPUS 2 , Panel: NZ4

Principal investigator: dr hab. Joanna Gabriela Mika

Instytut Farmakologii PAN

New drug carriers in targeted anticancer therapy

Call: OPUS 1 , Panel: ST5

Principal investigator: prof. Artur Piotr Terzyk

Uniwersytet Mikołaja Kopernika, Wydział Chemii