Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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INNOvative antiSEPTic agents for a therapy with a broad spectrum of action

2015/19/B/NZ7/02380

Keywords:

surface active agents membrane as molecular target liposomal drug carriers molecular dynamics simulations

Descriptors:

  • ST6_12: Scientific computing, simulation and modelling tools
  • ST6_13: Bioinformatics, biocomputing, DNA and molecular computation
  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Politechnika Wrocławska

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Sebastian Kraszewski 

Number of co-investigators in the project: 7

Call: OPUS 10 - announced on 2015-09-15

Amount awarded: 1 231 200 PLN

Project start date (Y-m-d): 2016-09-30

Project end date (Y-m-d): 2021-09-29

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (6)
  • Articles in post-conference publications (3)
  • Book publications / chapters in book publications (1)
  1. A Systematic Approach: Molecular Dynamics Study and Parametrisation of Gemini Type Cationic Surfactants
    Authors:
    Mateusz Rzycki, Aleksandra Kaczorowska, Sebastian Kraszewski, Dominik Drabik
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22(20), strony: 10939), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms222010939 - link to the publication
  2. Molecular mechanism of vSGLT inhibition by gneyulin reveals antiseptic properties against multidrug-resistant gram-negative bacteria
    Authors:
    Daniel Wiczew, Anna Borowska, Kinga Szkaradek, Tomasz Biegus, Kamil Woźniak, Marcelina Pyclik, Magdalena Sitarska, Łukasz Jaszewski, Łukasz Radosiński, Beata Hanus-Lorenz, Sebastian Kraszewski
    Academic press:
    Journal of Molecular Modeling (rok: 2019, tom: 25, strony: 186), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00894-019-4073-9 - link to the publication
  3. Mechanical Properties Determination of DMPC, DPPC, DSPC, and HSPC Solid-Ordered Bilayers
    Authors:
    Dominik Drabik, Grzegorz Chodaczek, Sebastian Kraszewski, Marek Langner
    Academic press:
    Langmuir (rok: 2020, tom: 36 (14), strony: 3826-3835), Wydawca: Acs Publications
    Status:
    Published
    DOI:
    10.1021/acs.langmuir.0c00475 - link to the publication
  4. Diptool - a novel numerical tool for membrane interactions analysis, applying to antimicrobial detergents and drug delivery aids
    Authors:
    Mateusz Rzycki, Sebastian P. Kraszewski, Marta Gładysiewicz-Kudrawiec
    Academic press:
    Materials (rok: 2021, tom: 14(21), strony: 45305), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ma14216455 - link to the publication
  5. Unraveling the mechanism of octenidine and chlorhexidine on membranes: does electrostatics matter?
    Authors:
    Mateusz Rzycki, Dominik Drabik, Kamila Szostak-Paluch, Beata E. Hanus-Lorenz, Sebastian P. Kraszewski
    Academic press:
    Biophysical Journal (rok: 2021, tom: 120(16), strony: 3392-3408), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bpj.2021.06.027 - link to the publication
  6. New lipid formulation of octenidine dihydrochloride
    Authors:
    Kamila Szostak, Aleksander Czogalla, Magdalena Przybyło & Marek Langner
    Academic press:
    Journal of Liposome Research (rok: 2017, tom: 45297, strony: 6), Wydawca: Taylor & Francis Online
    Status:
    Published
    DOI:
    10.1080/08982104.2016.1275678 - link to the publication
  1. Narzędzia numeryczne w projektowaniu nowoczesnych antyseptyków
    Authors:
    B. Hanus-Lorenz, D. Drabik, M. Rzycki, S. Kraszewski
    Conference:
    Współczesna myśl techniczna w naukach medycznych i biologicznych : X sympozjum (rok: 2019, ), Wydawca: Oddział Polskiej Akademii Nauk we Wrocławiu
    Data:
    konferencja 14-15 czerwca 2019 roku
    Status:
    Published
  2. Molecular sharp edge, the antiseptic agents for cell membrane disruption
    Authors:
    Dominik Drabik, Beata Hanus-Lorenz, Kamila Szostak, Sebastian Kraszewski
    Conference:
    5th Conference on Nano- and Micromechanics (CNM) conference (rok: 2017, ), Wydawca: Wrocław University of Science and Technology Faculty of Microsystem Electronics and Photonics
    Data:
    konferencja 4-6.07.2017
    Status:
    Published
  3. Powinowactwo i selektywność związków powierzchniowo czynnych z rodziny surfaktantów gemini
    Authors:
    Mateusz Rzycki, Beata Hanus-Lorenz, Marta Gładysiewicz-Kudrawiec, Sebastian Kraszewski
    Conference:
    Współczesna myśl techniczna w naukach medycznych i biologicznych : X sympozjum (rok: 2019, ), Wydawca: Oddział Polskiej Akademii Nauk we Wrocławiu
    Data:
    konferencja 14-15 czerwca 2019 roku
    Status:
    Published
  1. Towards Mimetic Membrane Systems in Molecular Dynamics: Characteristics of E. Coli Membrane System
    Authors:
    Mateusz Rzycki, Sebastian Kraszewski, Dominik Drabik
    Book:
    Lecture Notes in Computer Science (rok: 2021, tom: 12743, strony: 551-563), Wydawca: Springer
    Status:
    Published

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