Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Directed screening and evaluation of novel bactericidal compounds active againsttubercle bacilli and Mycobacterium abscessus.

2023/49/B/NZ7/01421

Keywords:

tuberculosis drug-resistance drug-targets tuberculostatics

Descriptors:

  • NZ7_14:

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Instytut Biologii Medycznej PAN

woj. łódzkie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Jarosław Dziadek 

Number of co-investigators in the project: 8

Call: OPUS 25 - announced on 2023-03-16

Amount awarded: 3 128 214 PLN

Project start date (Y-m-d): 2024-01-29

Project end date (Y-m-d): 2028-01-28

Project duration:: 48 months (the same as in the proposal)

Project status: Pending project

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (4)
  1. Benzenesulfonohydrazide-tethered non-fused and fused heterocycles as potential anti-mycobacterial agents targeting enoyl acyl carrier protein reductase (InhA) with antibiofilm activity.
    Authors:
    Tarfah Al-Warhi, Ahmed Sabt, Małgorzata Korycka-Machala, Asmaa F. Kassem, Moataz A. Shaldam, Hoda Atef Abdelsattar Ibrahim, Malwina Kawka, Bozena Dziadek, Magdalena Kuzioła, Wagdy M. Eldehna * and Jarosław Dziadek*
    Academic press:
    RSC Adv. (rok: 2024, tom: 14, strony: 30165), Wydawca: The Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/d4ra05616g - link to the publication
  2. New coumarin linked thiazole derivatives as antimycobacterial agents: Design, synthesis, enoyl acyl carrier protein reductase (InhA) inhibition and molecular modeling.
    Authors:
    Kassem AF, Sabt A, Korycka-Machala M, Shaldam MA, Kawka M, Dziadek B, Kuzioła M, Dziadek J, Batran RZ.
    Academic press:
    Bioorganic Chemistry (rok: 2024, tom: 150, strony: 107511), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bioorg.2024.107511 - link to the publication
  3. Identification of 2-(N-aryl-1,2,3-triazol-4-yl) quinoline derivatives as antitubercular agents endowed with InhA inhibitory activity.
    Authors:
    Sabt A, Abdulla MH, Ebaid MS, Pawełczyk J, Abd El Salam HA, Son NT, Ha NX, Vaali Mohammed MA, Traiki T, Elsawi AE, Dziadek B, Dziadek J, Eldehna WM.
    Academic press:
    Frontiers in Chemistry (rok: 2024, tom: 12, strony: 1424017), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fchem.2024.1424017 - link to the publication
  4. Design, synthesis and computational studies of new azaheterocyclic coumarin derivatives as anti-Mycobacterium tuberculosis agents targeting enoyl acyl carrier protein reductase (InhA).
    Authors:
    Batran RZ, Sabt A, Dziadek J, Kassem AF.
    Academic press:
    RSC Adv. (rok: 2024, tom: 30, strony: 21763-21777), Wydawca: The Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/d4ra02746a - link to the publication

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