Projects funded by the NCN

A new strategy to fight antibiotic resistance based on hybrids of fluoroquinolones and quaternary ammonium salts

Call: SONATA 20 , Panel: NZ7

Principal investigator: dr Joanna Dagmara Fedorowicz

Gdański Uniwersytet Medyczny

The role of EZH2 activity in the development of resistance to targeted therapy in melanoma

Call: OPUS 28 , Panel: NZ7

Principal investigator: dr Michał Jerzy Woźniak

Uniwersytet Medyczny w Łodzi

Parallel microevolution of metabolic plasticity and chemoresistance of cancer cells: a key to understanding cancer relap...

Call: OPUS 28 , Panel: NZ3

Principal investigator: prof. Jarosław Piotr Czyż

Uniwersytet Jagielloński

Supramolecular nanoparticles able to block calcium channels in cancer cells

Call: SONATA BIS 14 , Panel: ST11

Principal investigator: dr hab. Marek Brzeziński

Centrum Badań Molekularnych i Makromolekularnych PAN

A new universal method for the isolation and deep proteomic characterization of extracellular vesicles to study drug res...

Call: PRELUDIUM 23 , Panel: NZ2

Principal investigator: Bianka Świderska

Instytut Biochemii i Biofizyki PAN

Disruption of the posttranslational activation of the translation factor EF-P as a new target for antimicrobial agents.

Call: OPUS 27 , Panel: NZ7

Principal investigator: dr Piotr Wilk

Uniwersytet Jagielloński

Precision double strike against non-small cell lung cancer. Insights into multidirectional therapies and the landscape o...

Call: OPUS 27 , Panel: NZ5

Principal investigator: dr Katarzyna Anna Malarz

Politechnika Śląska

Exploiting the weakness of lymphoma: spectroscopic identification of biomarkers for lymphoma metabolism and inducing its...

Call: PRELUDIUM 23 , Panel: ST4

Principal investigator: Patrycja Dawiec

Uniwersytet Jagielloński

Evaluation of the relationship between doxorubicin resistance, epithelial-mesenchymal plasticity, and effects of selecte...

Call: PRELUDIUM 23 , Panel: NZ5

Principal investigator: Dominika Kunachowicz

Uniwersytet Medyczny im. Piastów Śląskich we Wrocławiu, Wydział Farmaceutyczny z Oddziałem Analiutyki Medycznej

Evaluation of the role of miRNA as a peripheral biomarker of drug resistance in epilepsy using biosensors for electroche...

Call: OPUS 27 , Panel: NZ5

Principal investigator: dr hab. Janusz Szyndler

Warszawski Uniwersytet Medyczny

Optogenetic and chemogenetic identification of brain circuits and cellular mechanisms underlying antidepressants resista...

Call: OPUS 26 , Panel: NZ7

Principal investigator: prof. Mariusz Papp

Instytut Farmakologii PAN

Directed screening and evaluation of novel bactericidal compounds active againsttubercle bacilli and Mycobacterium absce...

Call: OPUS 25 , Panel: NZ7

Principal investigator: prof. Jarosław Dziadek

Instytut Biologii Medycznej PAN

Cuproptosis, a novel pathway of regulated cell death as a therapeutic target in treatment-naïve and targeted therapy-res...

Call: OPUS 25 , Panel: NZ5

Principal investigator: dr hab. Mariusz Łukasz Hartman

Uniwersytet Medyczny w Łodzi, Wydział Lekarski

INVADOPODIA IN AXL-DRIVEN CANCER INVASION AND DRUG RESISTANCE

Call: OPUS 25 , Panel: NZ3

Principal investigator: dr Daria Paulina Zdżalik-Bielecka

Uniwersytet Warszawski, Wydział Biologii

Bis(benzosiloxaboroles) as a new class of potential antibiotics - a perspective solution to growing problem of antimicro...

Call: PRELUDIUM 22 , Panel: ST5

Principal investigator: Krzysztof Nowicki

Politechnika Warszawska, Wydział Chemiczny

Computational alchemy and experimental validation: a hybrid approach for designing new antimicrobial peptides

Call: PRELUDIUM 22 , Panel: NZ1

Principal investigator: Piotr Maciej Chyży

Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

Conjugates of peptide nucleic acids with aminoglycosides and fluoroquinolones as a novel strategy to target multi-drug r...

Call: PRELUDIUM 22 , Panel: ST5

Principal investigator: Izabela Siekierska

Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

Targeted poloxamer micelles with selected drugs as a strategy for overcoming the mechanisms of multidrug resistance in p...

Call: PRELUDIUM BIS 4 , Panel: NZ7

Principal investigator: prof. Tomasz Adam Gośliński

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu

Plant bacterial endophytes as an important antibiotic-resistance dissemination vector

Call: SONATA 18 , Panel: NZ9

Principal investigator: dr Magdalena Marta Zalewska

Uniwersytet Warszawski, Wydział Biologii

Regulatory network and interactome of inner membrane drug/metabolite transporters in bacteria – implications for physiol...

Call: OPUS 23 , Panel: NZ2

Principal investigator: dr hab. Aneta Agnieszka Bartosik

Instytut Biochemii i Biofizyki PAN

Role of the PARP1/HPF1 complex in the conferring of resistance to doxorubicin in triple negative breast cancer

Call: PRELUDIUM 21 , Panel: NZ5

Principal investigator: Magdalena Alicja Strachowska

Uniwersytet Łódzki, Wydział Biologii i Ochrony Środowiska

Role of natural products in overcoming drug resistance in Mycobacterium tuberculosis

Call: OPUS 23 , Panel: NZ7

Principal investigator: dr Elwira Zofia Sieniawska

Uniwersytet Medyczny w Lublinie

The role of Candida albicans' plasma membrane sphingolipids in the potentially new mechanism of drug resistance and in t...

Call: OPUS 22 , Panel: NZ1

Principal investigator: dr hab. Anna Janina Krasowska

Uniwersytet Wrocławski, Wydział Biotechnologii

Nanospectroscopic imaging of native biological membranes: Is the cell membrane the key for understanding the mechanism o...

Call: SONATA BIS 11 , Panel: ST4

Principal investigator: dr Katarzyna Pogoda

Instytut Fizyki Jądrowej im. Henryka Niewodniczańskiego PAN

RE-SENSE: Dual-loaded lipid nanoparticles to overcome the resistance of non-small cell lung cancer cells to personalized...

Call: PRELUDIUM 20 , Panel: NZ7

Principal investigator: Mikołaj Czajkowski

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu

Evaluation of NOTCH1- and NOTCH3-dependent anticancer drug resistance in a 2D and 3D model of Head and Neck Squamous Cel...

Call: PRELUDIUM 20 , Panel: NZ5

Principal investigator: dr Joanna Elżbieta Kałafut

Uniwersytet Medyczny w Lublinie

Relationship between ATPase activity stimulation and transport - the case of selective Medicago truncatula ABCG transpor...

Call: PRELUDIUM 20 , Panel: NZ1

Principal investigator: dr Konrad Mateusz Pakuła

Instytut Chemii Bioorganicznej PAN

In search for molecular targets to overcome doxorubicin resistance in triple-negative breast cancer with the use of inno...

Call: PRELUDIUM 20 , Panel: NZ7

Principal investigator: Anna Karolina Pogorzelska

Narodowy Instytut Leków

AXL receptor signaling in cancer cell growth and drug resistance

Call: OPUS 20 , Panel: NZ3

Principal investigator: prof. Marta Elżbieta Miączyńska

Międzynarodowy Instytut Biologii Molekularnej i Komórkowej

Propolis and polyphenols derived from this product as potential antifungal agents

Call: OPUS 20 , Panel: NZ7

Principal investigator: dr hab. Piotr Szweda

Politechnika Gdańska

The role of vitamin D receptor in 5-fluorouracil responsiveness of colorectal cancer cells

Call: SONATA 16 , Panel: NZ5

Principal investigator: dr Magdalena - Milczarek

Instytut Immunologii i Terapii Doświadczalnej im. Ludwika Hirszfelda Polskiej Akademii Nauk

Electroporation-based manipulation of drug resistance in cancer using novel nanosecondasymmetrical pulse sequences

Call: DAINA 2 , Panel: NZ7

Principal investigator: dr hab. Julita Kulbacka

Uniwersytet Medyczny im. Piastów Śląskich we Wrocławiu, Wydział Farmaceutyczny z Oddziałem Analiutyki Medycznej, Wydział Farmaceutyczny

Digestate from agricultural biogas plants as a reservoir of drug-resistance – a real risk to the environment?

Call: PRELUDIUM 19 , Panel: NZ9

Principal investigator: Izabela Wolak

Uniwersytet Warmińsko-Mazurski w Olsztynie, Wydział Geoinżynierii

Dual CBR1-AKR1C3 inhibitors as a new approach to improve effectiveness and safety of anthracycline therapy.

Call: PRELUDIUM 19 , Panel: NZ7

Principal investigator: Marek Andrzej Jamrozik

Uniwersytet Jagielloński, Collegium Medicum

Effect of the co-treatment of municipal wastewater and landfill leachate on the spread of ARGs in the environment

Call: PRELUDIUM 19 , Panel: NZ9

Principal investigator: Małgorzata Czatzkowska

Uniwersytet Warmińsko-Mazurski w Olsztynie, Wydział Geoinżynierii

Assessment of therapeutic value and usefulness of new generation antibiotics and their metabolites as resistance markers...

Call: PRELUDIUM 19 , Panel: ST4

Principal investigator: Katarzyna Joanna Pauter-Iwicka

Uniwersytet Mikołaja Kopernika, Wydział Chemii

Galactosylceramide as a regulator of apoptotic gene expression and modulator of drug resistance in breast cancer cells.

Call: OPUS 18 , Panel: NZ5

Principal investigator: prof. Maciej Ugorski

Uniwersytet Przyrodniczy we Wrocławiu, Wydział Medycyny Weterynaryjnej

Gankyrin protein as a new potential therapeutic target in multiple myeloma

Call: OPUS 18 , Panel: NZ5

Principal investigator: dr hab. Irena Misiewicz-Krzemińska

Instytut Hematologii i Transfuzjologii

Application of cold atmospheric pressure plasmas generated in contact with a flowing liquid for direct degradation of an...

Call: SONATA 15 , Panel: ST8

Principal investigator: dr hab. Anna Patrycja Dzimitrowicz

Politechnika Wrocławska

The use of evolutionary patterns in the optimization of chemotherapy of tuberculosis

Call: SONATA BIS 9 , Panel: NZ6

Principal investigator: dr Alina Ewa Minias

Instytut Biologii Medycznej PAN

The use of olaparib and ATR / CHK1 kinase inhibitors as a targeted anti-cancer therapy based on synthetic lethality

Call: SONATA BIS 9 , Panel: NZ7

Principal investigator: dr hab. Aneta Katarzyna Rogalska

Uniwersytet Łódzki, Wydział Biologii i Ochrony Środowiska

Dissecting of the novel mechanisms in multi-drug resistance associated with vault's proteins and translation initiation ...

Call: SONATA BIS 8 , Panel: NZ7

Principal investigator: dr hab. Witold Szaflarski

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, Wydział Lekarski II

Molecular determinants of drug resistance influenza virus causing infection in humans in diffrent epidemic seasons in Po...

Call: PRELUDIUM 15 , Panel: NZ7

Principal investigator: dr Ewelina Maria Hallmann

Narodowy Instytut Zdrowia Publicznego - Państwowy Zakład Higieny (NIZP - PZH)

Determination of mechanisms and critical molecular partners controlling the multidrug resistance proteins (P-gp and BCRP...

Call: OPUS 15 , Panel: NZ3

Principal investigator: dr hab. Marlena Godlewska

CENTRUM MEDYCZNE KSZTAŁCENIA PODYPLOMOWEGO, Studium Kliniczno-Dydaktyczne

Genomic insights into the mechanisms of drug resistance, virulence and transmission of Mycobacterium tuberculosis strain...

Call: DAINA 1 , Panel: NZ6

Principal investigator: dr Tomasz Jagielski

Uniwersytet Warszawski, Wydział Biologii

Evaluation of anticancer properties and molecular mechanisms of action of new hybrid molecules containing uracil skeleto...

Call: PRELUDIUM 13 , Panel: NZ3

Principal investigator: dr Angelika Agata Długosz-Pokorska

Uniwersytet Medyczny w Łodzi, Wydział Lekarski

Study on metabolism of microorganisms treated with metal nanoparticles, antibiotics, metal ions and their combinations u...

Call: PRELUDIUM 13 , Panel: ST4

Principal investigator: Agnieszka Maria Rogowska

Uniwersytet Mikołaja Kopernika, Wydział Chemii

Role of fructose in Candida albicans multiple drug resistance

Call: PRELUDIUM 13 , Panel: NZ1

Principal investigator: Jakub Suchodolski

Uniwersytet Wrocławski, Wydział Biotechnologii

CBR1-dependent metabolism and ABCB1-dependent effux of doxorubicin - search for a novel mechanism of reversing resistanc...

Call: PRELUDIUM 13 , Panel: NZ7

Principal investigator: Kamil Tomasz Piska

Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny

Studies of the role of toxin-antitoxin systems in antibiotics resistance in staphylococci.

Call: OPUS 13 , Panel: NZ6

Principal investigator: dr hab. Benedykt Władyka

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii