Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Role of natural products in overcoming drug resistance in Mycobacterium tuberculosis

2022/45/B/NZ7/00412

Keywords:

metabolomics lipidomok transcriptomics bioinformatics natural products LC-MS drug resistance

Descriptors:

  • NZ2_4: Metabolomics
  • NZ2_7: Bioinformatics
  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Medyczny w Lublinie

woj.

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Elwira Zofia Sieniawska 

Number of co-investigators in the project: 6

Call: OPUS 23 - announced on 2022-03-28

Amount awarded: 1 393 486 PLN

Project start date (Y-m-d): 2023-03-01

Project end date (Y-m-d): 2026-02-28

Project duration:: 36 months (the same as in the proposal)

Project status: Pending project

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (2)
  1. Molecular insight into thymoquinone mechanism of action against Mycobacterium tuberculosis
    Authors:
    Grzegorz Jankowski, Rafał Sawicki, Wiesław Truszkiewicz, Natalia Wolan, Marcin Ziomek, Benita Hryć and Elwira Sieniawska
    Academic press:
    Frontiers in Microbiology (rok: 2024, tom: 15, strony: 1353875), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fmicb.2024.1353875 - link to the publication
  2. Sulphides from garlic essential oil dose‑dependently change the distribution of glycerophospholipids and induce N6‑tuberculosinyladenosine formation in mycobacterial cells
    Authors:
    Rafał Sawicki, Jarosław Widelski, Wiesław Truszkiewicz, Sławomir Kawka, Guoyin Kai & Elwira Sieniawska
    Academic press:
    Scientific Reports (rok: 2023, tom: 13, strony: 20351), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1038/s41598-023-47750-0 - link to the publication

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