Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Electroporation-based manipulation of drug resistance in cancer using novel nanosecondasymmetrical pulse sequences

2020/38/L/NZ7/00342

Keywords:

electroporation asymmetric nanosecond pulse drug resistance drug delivery

Descriptors:

  • NZ3_001:
  • NZ7_014:

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Medyczny im. Piastów Śląskich we Wrocławiu, Wydział Farmaceutyczny

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Julita Kulbacka 

Number of co-investigators in the project: 6

Call: DAINA 2 - announced on 2020-06-15

Amount awarded: 1 004 370 PLN

Project start date (Y-m-d): 2021-06-10

Project end date (Y-m-d): 2024-06-09

Project duration:: 36 months (the same as in the proposal)

Project status: Project completed

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (10)
  1. Does the shape of the electric pulse matter in electroporation?
    Authors:
    Vitalij Novickij, Nina Rembiałkowska, Wojciech Szlasa and Julita Kulbacka
    Academic press:
    Frontiers in Oncology (rok: 2022, tom: 12, strony: 958128), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fonc.2022.958128 - link to the publication
  2. Effects of Nanosecond Pulsed Electric Field on Immune Checkpoint Receptors in Melanoma Cells
    Authors:
    Natalia Sauer, Wojciech Szlasa, Anna Szewczyk, Vitalij Novickij, Jolanta Saczko, Dagmara Baczyńska, Małgorzata Daczewska, Julita Kulbacka
    Academic press:
    Pharmaceuticals (Basel) . (rok: 2023, tom: 16(10), strony: 1362), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ph16101362 - link to the publication
  3. TIM-3 as a promising target for cancer immunotherapy in a wide range of tumors
    Authors:
    Natalia Sauer, Natalia Janicka, Wojciech Szlasa, Bartłomiej Skinderowicz, Katarzyna Kołodzińska, Wioletta Dwernicka, Małgorzata Oślizło, Julita Kulbacka, Vitalij Novickij, Katarzyna Karłowicz‑Bodalska
    Academic press:
    Cancer Immunology, Immunotherapy (rok: 2023, tom: 72, strony: 3405–3425), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00262-023-03516-1 - link to the publication
  4. Effects of Nanosecond Pulsed Electric Field on Immune Checkpoint Receptors in Melanoma Cells
    Authors:
    Natalia Sauer, Wojciech Szlasa, Anna Szewczyk, Vitalij Novickij, Jolanta Saczko, Dagmara Baczyńska, Małgorzata Daczewska, Julita Kulbacka
    Academic press:
    Pharmaceuticals (Basel) . (rok: 2023, tom: 16(10), strony: 1362), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ph16101362 - link to the publication
  5. High Frequency Bipolar Electroporator with Double-Crowbar Circuit for Load-Independent Forming of Nanosecond Pulses
    Authors:
    Vitalij Novickij, Gediminas Staigvila, Arunas Murauskas , Nina Rembialkowska , Julita Kulbacka and Jurij Novickij
    Academic press:
    Applied Sciences (rok: 2022, tom: 12, strony: 1370), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/app12031370 - link to the publication
  6. The influence of asymmetrical bipolar pulses and interphase intervals on the bipolar cancellation phenomenon in the ovarian cancer cell line
    Authors:
    Zofia Łapińska, Vitalij Novickij, Nina Rembiałkowska, Anna Szewczyk, Magdalena Dubińska-Magiera, Julita Kulbacka, Jolanta Saczko
    Academic press:
    Bioelectrochemistry (rok: 2023, tom: 153, strony: 108483), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bioelechem.2023.108483 - link to the publication
  7. The Role of Chloride Channels in the Multidrug Resistance
    Authors:
    Bartosz Wilczyński , Alicja Dąbrowska, Jolanta Saczko and Julita Kulbacka
    Academic press:
    Membranes (rok: 2021, tom: 12(1), strony: 38), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/membranes12010038 - link to the publication
  8. TIM-3 as a promising target for cancer immunotherapy in a wide range of tumors
    Authors:
    Natalia Sauer, Natalia Janicka, Wojciech Szlasa, Bartłomiej Skinderowicz, Katarzyna Kołodzińska, Wioletta Dwernicka, Małgorzata Oślizło, Julita Kulbacka, Vitalij Novickij, Katarzyna Karłowicz‑Bodalska
    Academic press:
    Cancer Immunology, Immunotherapy (rok: 2023, tom: 72, strony: 3405–3425), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00262-023-03516-1 - link to the publication
  9. Micro- and Nanosecond Pulses Used in Doxorubicin Electrochemotherapy in Human Breast and Colon Cancer Cells with Drug Resistance
    Authors:
    Nina Rembiałkowska , Vitalij Novickij , Dagmara Baczyńska , Magda Dubińska-Magiera , Jolanta Saczko , Julia Rudno-Rudzińska , Magdalena Maciejewska and Julita Kulbacka
    Academic press:
    Molecules (rok: 2022, tom: 27, strony: 2052), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules27072052 - link to the publication
  10. Improving NonViral Gene Delivery Using MHz Bursts of Nanosecond Pulses and Gold Nanoparticles for Electric Field Amplification
    Authors:
    Eivina Radzeviciute-Valciuke , Jovita Gecaite˙, Augustinas Želvys, Aukse Zinkeviciene, Rokas Žalneravicius, Veronika Malyško-Ptašinske, Aušra Nemeikaite Ceniene, Vytautas Kašeta, Natalija German , Jurij Novickij, Almira Ramanaviciene˙ , Julita Kulbacka and Vitalij Novickij
    Academic press:
    Pharmaceutics (rok: 2023, tom: 15(4), strony: 1178), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/pharmaceutics15041178 - link to the publication

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